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Alireza Karbalayghareh

@karbalayghareh

Senior Research Scientist at CZ Biohub New York, AI/ML Platform. Building causal AI models of immune cells.

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30.11.2024
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Latest posts by Alireza Karbalayghareh @karbalayghareh

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Exciting symposium on AI and Biology at EMBO | EMBL in Heidelberg on 10-13 March 2026!

Excellent lineup of invited speakers across various scales of biology!

Deadline for abstract submission is coming up β€” Dec 2.

πŸ”— www.embl.org/about/info/c...

#EESAIBio @EMBLEvents

07.11.2025 00:16 πŸ‘ 9 πŸ” 7 πŸ’¬ 0 πŸ“Œ 1
Predicting the regulatory genome - Nature Reviews Genetics In this Comment, the authors overview the latest deep learning models for predicting regulatory function from genomic sequence and highlight key topics going forward, including the trade-off between s...

Our review of the current AI modeling approaches for predicting the regulatory genome, what we do best, which tasks we struggle most, and where we should be heading to address those challenges:

www.nature.com/articles/s41...

21.09.2025 13:09 πŸ‘ 2 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0

Excited for a major milestone in our efforts to map enhancers and interpret variants in the human genome:

The E2G Portal! e2g.stanford.edu

This collates our predictions of enhancer-gene regulatory interactions across >1,600 cell types and tissues.

Uses cases πŸ‘‡

1/

18.09.2025 16:14 πŸ‘ 84 πŸ” 36 πŸ’¬ 2 πŸ“Œ 1
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@jengreitz.bsky.social l & my lab want to co-hire a computational biologist/biostatistician with project management expertise to help map the regulatory code of the human genome and discover genetic mechanisms of disease.

Details below
careersearch.stanford.edu/jobs/computa...

Plz RT

19.08.2025 00:29 πŸ‘ 54 πŸ” 59 πŸ’¬ 1 πŸ“Œ 1

Great work Tom and the team! Congrats!

06.08.2025 17:17 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

One thing that really bothers me with the new "virtual cell" terminology is that it is currently largely focused on a very narrow definition of models that can predict effects of trans perturbations (gene dosage, drugs etc) on gene expression. 1/

28.06.2025 10:38 πŸ‘ 104 πŸ” 29 πŸ’¬ 1 πŸ“Œ 0

Excited to launch our AlphaGenome API goo.gle/3ZPUeFX along with the preprint goo.gle/45AkUyc describing and evaluating our latest DNA sequence model powering the API. Looking forward to seeing how scientists use it! @googledeepmind

25.06.2025 14:29 πŸ‘ 219 πŸ” 81 πŸ’¬ 5 πŸ“Œ 9

Great opportunity!

20.06.2025 19:30 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

Congratulations!

29.05.2025 21:09 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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The premier conference on Machine Learning for Computational Biology is Sep 9-10 at the NY Genome Center in NYC!

Submission deadline is June 1 for 2-page abstracts and 8-page papers (eligible for proceedings track).

Registration is now open! (Link below)

Please retweet!

16.05.2025 11:26 πŸ‘ 28 πŸ” 13 πŸ’¬ 2 πŸ“Œ 0
Preview
Machine Learning in Computational Biology Youtube channel for the Machine Learning in Computational Biology conference: https://mlcb.github.io/

Free in-person registration is open for #MLCB2025! Sept 10-11 at @nygenome.org and online at youtube.com/@mlcbconf. Paper/abstract deadline is June 1, more deets including our fantastic invited speaker lineup at mlcb.org! Please RP.

15.05.2025 00:24 πŸ‘ 41 πŸ” 22 πŸ’¬ 0 πŸ“Œ 0
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The short talk and scholarship deadlines for the @keystonesymposia.bsky.social AI in Molecular Biology meeting in September are coming up fast, May 20th. Looking forward to seeing the submissions! www.keystonesymposia.org/conferences/...

11.05.2025 21:29 πŸ‘ 17 πŸ” 4 πŸ’¬ 0 πŸ“Œ 0

Great work!

18.04.2025 00:42 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

Very cool work!

22.02.2025 22:44 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

My heart goes out to all of the people at the NIH and CDC who were fired recently. These people weren't fired for being bad at their job or a waste of resources -- they were fired because they were easy to fire by outsiders trying to meet a quota. They worked years/decades.. for this?

16.02.2025 13:31 πŸ‘ 46 πŸ” 5 πŸ’¬ 1 πŸ“Œ 1

It’s been buried in all the news today, but every scientist in the US should pay attention to this:

Mike Lauer went out on a limb for us all, sending out a memo saying institutes should start awarding grants. And it looks like Trump/Musk fired him for that. πŸ§ͺ

14.02.2025 21:40 πŸ‘ 1366 πŸ” 597 πŸ’¬ 20 πŸ“Œ 20
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98% of NIH grants that should have gone out this month, didn't. Despite court orders 'unfreezing' the funds, they are frozen. Biomedical research will grind to a halt. Clinical trials will end. All for no reason: the total impact on the US budget is miniscule

12.02.2025 15:19 πŸ‘ 3538 πŸ” 1263 πŸ’¬ 50 πŸ“Œ 69

[SAVE THE DATE] MLCB 2025 is happening Sept 10-11 at the NY Genome Center in NYC!

Attend the premier conference at the intersection of ML & Bio, share your research and make lasting connections!

Submission deadline: June 1
More details: mlcb.github.io

Help spread the wordβ€”please RT! #MLCB2025

05.02.2025 02:50 πŸ‘ 41 πŸ” 27 πŸ’¬ 1 πŸ“Œ 4

#MLCB2025 will be Sept 10-11 at @nygenome.org in NYC! Paper deadline June 1st & in-person registration will open in May. Please sign up for our mailing list groups.google.com/g/mlcb/ for future announcements. More details at mlcb.github.io. Please RP!

27.01.2025 18:40 πŸ‘ 33 πŸ” 14 πŸ’¬ 0 πŸ“Œ 1

Interesting! I wonder if the number of binding sites (weak or strong) in the enhancers can also play a role?

21.01.2025 15:14 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

Our ChromBPNet preprint out!

www.biorxiv.org/content/10.1...

Huge congrats to Anusri! This was quite a slog (for both of us) but we r very proud of this one! It is a long read but worth it IMHO. Methods r in the supp. materials. Bluetorial coming soon below 1/

25.12.2024 23:48 πŸ‘ 231 πŸ” 89 πŸ’¬ 7 πŸ“Œ 5

Great positions! Go work with Peter, he is excellent!

23.12.2024 20:28 πŸ‘ 5 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0
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1/ πŸŽ„ What’s the best gift under the tree for a computational biologist? 🎁 A new experimental assay that refines our view of gene regulation: ACCESS-ATAC! This creative idea from Richard Sherwood was developed collaboratively between his lab and mine. #Genomics
www.biorxiv.org/content/10.1...

23.12.2024 15:18 πŸ‘ 105 πŸ” 31 πŸ’¬ 2 πŸ“Œ 2

Proud of this work spearheaded by the phenomenal @jlfan.bsky.social and @mingxz.bsky.social in collaboration w/ Ben Izar! The past 3 years we've worked hard to unravel how #CNVs shape #tumor phenotypic plasticity seen in #singlecell #RNAseq data ➑️ #Echidna πŸ¦”

18.12.2024 14:08 πŸ‘ 17 πŸ” 6 πŸ’¬ 1 πŸ“Œ 0
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πŸŽ†4 years in the making! Thrilled to share the 1st spatial single cell aging clock ⏰ www.nature.com/articles/s41...

We use #AI + spatial transcriptomics to discover what makes some cells age faster/slower in the brain 🧠

Led by Eric Sun and awesome collaboration w/ @brunetlab.bsky.social🧡

18.12.2024 22:19 πŸ‘ 38 πŸ” 13 πŸ’¬ 1 πŸ“Œ 1
Research Technician - Cold Spring Harbor Laboratory Post a job in 3min, or find thousands of job offers like this one at jobRxiv!

🚨 We’re hiring! 🚨

The Simons Center for Quantitative Biology at Cold Spring Harbor Laboratory is looking for a Research Technician to join our team.

If you’re passionate about genomics, AI, and experimental science, we want to hear from you.

Help us spread the word!

jobrxiv.org/job/cold-spr...

17.12.2024 01:44 πŸ‘ 8 πŸ” 8 πŸ’¬ 1 πŸ“Œ 0

Thanks for supporting young scientist Anshul!

30.11.2024 23:49 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0