NealeLab

Two weeks left to get in your applications! ✍️
www.sussex.ac.uk/study/fees-f...

Common variation in meiosis genes shapes human recombination and aneuploidy - Nature Analysis of data from pre-implantation genetic testing sheds light on the genetic basis of meiotic-origin aneuploidy, the leading cause of human pregnancy loss, identifying common genetic variants ass...

Pregnancy loss is common in humans, and chromosomal abnormalities are the leading cause. Using genetic data from ~140,000 IVF embryos, we show that maternal variation in meiosis genes influences recombination and aneuploidy risk.

First authors: @saracarioscia.bsky.social & @aabiddanda.github.io

www.biorxiv.org/content/10.6...

After a long incubation, it is a huge pleasure to finally share the work of @luzmlopez.bsky.social, Jon Harper and their coauthors: "Localised negative feedback shapes genome-wide patterning of meiotic DNA breaks". @gdsc-sussex.bsky.social
www.biorxiv.org/content/10.6...

I think you are right on the A-DNA...in addition to the tilts, there may well be 11 bases per turn here.

The one thing I *did* check for. And yet still got paranoid...

Is it?! I'm just a lowly molecular biologist looking for a GIF... 😅
microbenotes.com/wp-content/u...

Now live on Find-A-PhD-dot-com:
Joint project between @labneale.bsky.social and @drjonbaxter.bsky.social @gdsc-sussex.bsky.social
Get in touch if you are interested in any and all of: Chromosomes, Genome Stability, Chromatin and DNA Topology in Mitosis and Meiosis.

www.findaphd.com/phds/project...

@science.org A small polymerase ribozyme that can synthesize itself and its complementary strand | Science www.science.org/doi/10.1126/... #RNA #ribozyme #evolution

Indeed! And this depiction is just of one... www.nature.com/articles/sre...

NOW LIVE!: PhD opening joint with @drjonbaxter.bsky.social at @gdsc-sussex.bsky.social
Get in touch and apply if you are interested in any and all of: Chromosomes, Genome Stability, Chromatin and DNA Topology in Mitosis and Meiosis.
www.sussex.ac.uk/study/fees-f...

Super strong representation from our department in SussexRNA at the RNA UK meeting in Windermere this week.

Many congrats to Jake, Courtney and Hope from the Ben Towler group, and Leandro Castellano, Lidia Vasilieva, Ben and Nikos for having abstracts accepted for presentation. 👏

Beautiful! Is this in real time (20 seconds?)
(Speed also seem to slow over time?)

Open letter from Ian Chapman to research and innovation community UKRI Chief Executive outlines changes to UKRI investment approach, addressing concerns about research funding and the financial position of STFC.

Changes in the UK R&I funding landscape - doing fewer things better. An open letter from Ian Chapman to research and innovation community:
www.ukri.org/news/open-le...

𝗢𝗽𝗲𝗻𝗔𝗜 𝗷𝘂𝘀𝘁 𝗹𝗮𝘂𝗻𝗰𝗵𝗲𝗱 𝗣𝗿𝗶𝘀𝗺—𝗮 𝗳𝗿𝗲𝗲 𝗟𝗮𝗧𝗲𝗫 𝗲𝗱𝗶𝘁𝗼𝗿 𝗳𝗼𝗿 𝘀𝗰𝗶𝗲𝗻𝘁𝗶𝘀𝘁𝘀. But this isn't about LaTeX. And it's not about training data. They could get… | Adam Hyde | 25 comments 𝗢𝗽𝗲𝗻𝗔𝗜 𝗷𝘂𝘀𝘁 𝗹𝗮𝘂𝗻𝗰𝗵𝗲𝗱 𝗣𝗿𝗶𝘀𝗺—𝗮 𝗳𝗿𝗲𝗲 𝗟𝗮𝗧𝗲𝗫 𝗲𝗱𝗶𝘁𝗼𝗿 𝗳𝗼𝗿 𝘀𝗰𝗶𝗲𝗻𝘁𝗶𝘀𝘁𝘀. But this isn't about LaTeX. And it's not about training data. They could get papers from arXiv or partner with Overleaf for that. So w...

"Writing papers is rarely (probably never) the rate-limiting step in scientific research"

Important to remember this. However painful writing is, however much more efficient we can make it, for experimental work it's the research that takes the time.

www.linkedin.com/feed/update/...

I'm just thankful that I successfully picked a right-handed GIF...😇

a computer generated image of a dna structure ALT: a computer generated image of a dna structure

Coming soon! PhD opening joint with @drjonbaxter.bsky.social at @gdsc-sussex.bsky.social
Keep a look out and get in touch if you are interested in any and all of: Chromosomes, Genome Stability, Chromatin and DNA Topology in Mitosis and Meiosis.

Not all great papers take a decade...but some certainly do.
Nevertheless, we'd first need a resourcing model that guaranteed a stable level of research funding per lab...

Still some time to register to this great meeting! Great science and great location for a very affordable registration cost!

It’s a massive problem across the sector, and I’m not sure what is the solution is…

Human eggs must segregate their chromosomes with exquisite precision — yet errors rise with maternal age, causing miscarriage & infertility.
Our new article on @biorxivpreprint.bsky.social shows why chromosome cohesion fails in aging eggs & how to improve it.
www.biorxiv.org/content/10.6... (1/10)

Oh - thanks for preparing! It is lovely to see the entire area, and I appreciate the effort!
(I just thought that the final image had been squished, not the source.)

Thanks for sharing these! Unfortunately, I think your final render has been a little squished on the X dimension. It comes out at 2x size as 7856 × 3712 pixels (= 3928 × 1856 at 50%, not 4096 x 1856). There is some visible anti-aliasing on the horizontal axis as a result:

Cool - thanks - the vertical size is more than I expected. This means you can look up and down quite a lot? I was thinking that the pitch angle would be more constrained.

Fantastic! Q: How large (in pixels) would the entire rendered viewpoint be (if it were generated as a bitmap)?

Skip to 1m 39s for my current coding hobby project 🙃

Image shows the panels of the final Calvin and Hobbes cartoon, published on December 31st 1995, drawn by comic artist Bill Watterson. It depicts Calvin (a young boy) and Hobbes (a stuffed tiger and his close companion) trekking outside in their winter clothes, across a fresh blanket of snow. Calvin: Wow, it really snowed last night! Isn't it wonderful! Hobbes: Everything familiar has disappeared! The world looks brand-new! Calvin: A new year. ... A fresh clean start! Hobbes: It's like having a big white sheet of paper to draw on! Calvin: A day full of possibilities! The two of them board their sled in anticipation. Calvin: It's a magical world, Hobbes ol' buddy... They set off on the sled out into the snow. Calvin: ... Let's go exploring!

30 years ago today, December 31st 1995, the last ever Calvin & Hobbes comic strip was published. Even now, I still find it so poignant & moving.

SMC and recombination enthusiasts: we updated our work describing the loop extrusion properties of budding yeast condensin and its function in biasing donor usage for mating-type switching. Lots of cool new data, check it out!
www.biorxiv.org/content/10.1...

Do #hybrids handle heat, cold better? ❄️🔥 Over 140 generations at 5C and 31C, #yeast #F2 hybrids adapted fast, were ~4× fitter in cold, more resilient to sudden flips. #Hybridization could turbocharge #adaptation, impacting #conservation & #agriculture. #Evolution www.yeastgenome.org/reference/41...

OLE RNA from Clostridium botulinum (pdb_00009lcr) is shown in pink on the left. ROOL RNAs can form cages built from 6 (right, top, pdb_00009j6y) or 8 (right, bottom, pdb_00009mds) subunits.

Large and intricate naturally occurring structures composed exclusively of RNA... ROOL!
More at Molecule of the Month: pdb101.rcsb.org/motm...