Eszter Lakatos

Sunny Crete for a great meeting about #cancer #ecology and #evolution

Still a few days to apply for a PhD studentship in my lab as part of the MSCA doctoral training network EVOMG! Come help us develop informative models of blood-based biopsies in cancer, and learn about the various evolutionary aspects that can aid medicine.
More info and application: www.evomg-dn.eu

Check out our article on the evolution of immune evasion in colorectal cancer. ⬇️
For a summary, see our Research Briefing now available online: rdcu.be/ePWC4

When Cancers Outsmart the Immune System from the Very Beginning Cancer research is often seen as an arms race between the immune system and cancer cells, unfolding gradually as tumors grow. But our new study on colorectal cancer suggests otherwise: the battle may ...

Now that our Nature Genetics paper is out, here’s a “Behind the Paper” post on how colorectal cancers outsmart the immune system from the beginning.

👉 communities.springernature.com/posts/when-c...

@eszterlakatos.bsky.social @trevorgraham.bsky.social #CancerResearch #Immunology #TME #Epigenetics

Epigenetically driven and early immune evasion in colorectal cancer evolution - Nature Genetics This study nominates immune escape as an early event in colorectal cancer and shows how this can be driven through both genetic and epigenetic changes.

New @natgenet.nature.com paper from the brilliant @eszterlakatos.bsky.social presents evidence that chromatin alterations disrupt antigen presentation & neoantigens in colorectal cancer. Also that immune escape is part of the "Big Bang", at the outset of CRC growth. www.nature.com/articles/s41...

📢 EvoMG-DN PhD applications are now open!
Join our EU-funded MSCA network and explore evolution, ageing, and disease.
👉 www.evomg-dn.eu

📅 Apply by 30 November 2025

#PhD #DoctoralTraining #MSCA #HorizonEurope #Genomics #EvolutionaryBiology #BiomedicalResearch#EarlyCareerResearchers

T cell receptor cross-reactivity prediction improved by a comprehensive mutational scan database Banerjee et al. present a comprehensive T cell receptor cross-reactivity database and a hierarchical Bayesian framework to predict T cell receptor targets. Together, they reveal structural and biochem...

Check out how we tackled one of the fundamental challenges in immunology, out today @cp-cellsystems.bsky.social: www.cell.com/cell-systems.... Our major innovations are BATCAVE and BATMAN, two new players to get us closer to solving TCR-pMHC predictions!

Sleep when the baby sleeps, eat when the baby eats, edit your manuscript when the baby edits their manuscript

🏆 Honoured to receive the 2025 Inaugural BACR Early Career Award!
Grateful to @thebacr.bsky.social and all who’ve supported me — esp. @trevorgraham.bsky.social, @eszterlakatos.bsky.social & @cancerresearchuk.org 💙
Reflections→ www.bacr.org.uk/news/2025-in...
#CancerResearch #EarlyCareer #ScienceWins

Very cool story and especially useful mathematical models for everyone to use! Check it out!!!

As much as it's a meaningless milestone, the mathematician in me is happy to see exactly 2^10 citations on the one random day I decide to finally visit my own Google Scholar :)

🚨With some delay, we're excited to announce that our proposal for a MSCA Doctoral Network on Evolutionary Medical Genomics (EvoMG-DN) got funded! 🎉

🧬 14 labs and 2 companies across 7 European countries will be coordinated by the EvoMG Joint Program at @crg.eu & @upf.edu.

europa.eu/!NNq63m

Happy to share details of this meeting and the exciting line-up of speakers. Hope to see you there. Please re-post www.crick.ac.uk/whats-on/5th...

Evolutionary and immune microenvironment dynamics during neoadjuvant treatment of esophageal adenocarcinoma - Nature Cancer Graham and colleagues analyzed locally advanced esophageal adenocarcinoma clinical trial patient samples and identified major changes in gene expression profiles and immune microenvironment compositio...

Tour de force from @melissabarroux.bsky.social on evolutionary and microenvironmental dynamics of oesophageal adenocarcinoma through neoadjuvant therapy

Published @natcancer.nature.com

Melissa is an outstanding new clinician scientist.. one to watch.

www.nature.com/articles/s43...

@icr.ac.uk

Combinatorics (find some fun objects to arrange and choose from)? Then basic probability (e.g. binomial distribution) - roll lots of dice or make up your own home lotto

📣Open PhD position in Machine Learning at Uppsala University. Focus: Bayesian mathematical models and methods for biomedicine.

Can we use the power of evolution to improve ovarian cancer treatment? Our latest paper says yes! Online now at Cancer Research. Thanks to
@trevorgraham.bsky.social coauthors and @cancerresearchuk.org for funding.

Smarter chemotherapy approach could delay drug resistance in ovarian cancer - Barts Cancer Institute - Queen Mary University of London Adaptive chemotherapy can prolong survival in lab models of ovarian cancer, according to new results. The findings could pave the way for a more effective and gentler approach to treating ovarian canc...

📰 Can we use the power of evolution to improve ovarian cancer survival?

A surprising approach called adaptive therapy holds promise, according to findings by @mlockley.bsky.social & team at @qmul.ac.uk & @icr.ac.uk.

Read more ➡️ www.bci.qmul.ac.uk/general-news...

#AACR25 #medsky #oncosky🧪

Guess this is a good reason to not get into neural network training or anything else with weight matrices.

Congratulations! 🎉

If you're a PhD student interested in using maths to understand cancer, this HCEMM summer school in Szeged, Hungary, is an excellent opportunity.

Registration is free and local costs are covered, so apply before 15th April.

Our #Cancer #Evolution summer school runs again 30 June-3 July at the beautiful Genome Campus in Hinxton, UK sponsored by @wellcometrust.bsky.social

Ideal for starters in the field; this year's focus is on using genomic data for cancer evo research.

Brilliant & inspiring faculty! bit.ly/40nLdDD

Data Scientist in Sutton | The Institute of Cancer Research View details and apply for this Data Scientist vacancy in Sutton. Salary Range: Commencement on the salary range is subject to comparable skills and experience. Future progression is based ...

We have an opening in our #DataScience core @icr.ac.uk.

The post will work on a breadth of topics across #cancer biology, but expertise in spatial data, single cell and data integration are priorities.

Details here: jobs.icr.ac.uk/vacancies/11...

@jobrxiv.bsky.social

Come work at the European Molecular Biology Laboratory in the beautiful science & university city Heidelberg as a Research Software Engineer on R/Bioconductor tools for biological data science and AI !

embl.wd103.myworkdayjobs.com/EMBL/job/Hei...

Low-coverage whole genome sequencing of low-grade dysplasia strongly predicts advanced neoplasia risk in ulcerative colitis Background The risk of developing advanced neoplasia (AN; colorectal cancer and/or high-grade dysplasia) in ulcerative colitis (UC) patients with a low-grade dysplasia (LGD) lesion is variable and dif...

Delighted our work using aneuploidy as a biomarker of colorectal cancer risk in inflammatory bowel disease is out: gut.bmj.com/content/earl...

The initial reaction from patients&families has been overwhelming

Led by Ibrahim AlBakir @yosoykit.bsky.social @cancerresearchuk.org @icrlondon.bsky.social

Applications for this "Black Leaders in Cancer" #PhD studentship with our lab @icrlondon.bsky.social close on Thursday... if you know of someone who might be interested please do pass the link on.

Genetic immune escape in cancer: timing and implications for treatment Genetic immune escape (GIE) alterations pose a significant challenge in cancer by enabling tumors to evade immune detection. These alterations, which …

Excited to share our perspective on genetic immune escape alterations and their impact on tumor evolution, metastasis, immunotherapy, and interactions with tumor-extrinsic factors. It was a pleasure collaborating with Diego on this -hope you enjoy the read!☺️

www.sciencedirect.com/science/arti...

Luminal breast epithelial cells of BRCA1 or BRCA2 mutation carriers and noncarriers harbor common breast cancer copy number alterations - Nature Genetics Single-cell DNA sequencing identifies recurrent copy number changes in healthy breast tissue from women with wild-type or germline BRCA1 or BRCA2 mutations.

Our paper on chromosomal abnormalities in normal breast tissue from BRCA carriers came out last week.
www.nature.com/articles/s41...

100% agree. My worst enemy is the ranking drop-down "how would you rate the quality of the article? - top 10%/ 25% / etc". Having been a reviewer filling these out, I'd know not to pay attention to it as editor.

Calling all systems and computational biologists in search of a faculty position:

We have Assistant and Associate Professor positions! 🚀

Pittsburgh is beautiful, and we are doing amazing science here.

cfopitt.taleo.net/careersectio...

cfopitt.taleo.net/careersectio...

Please apply by Dec 2!