Martin Mikl

Postdoctoral Researcher - Spatial Omics for Colorectal Cancer Risk Stratification

My lab at ETHZ has an opening for a postdoc in spatial risk stratification: www.jobs.ethz.ch/job/view/JOP.... Please apply if suitable, or RT, thanks!

I have one open PhD position. Maybe one of the last PhD positions in the lab as I'm planning changes in what we do and how we will do it some five years from now. I'm offering freedom (pun intended), respect, an interesting project, and a good full time contract w. health insurance.

Rapid folding of nascent RNA regulates eukaryotic RNA biogenesis An RNA′s catalytic, regulatory, or coding potential depends on RNA structure formation. Because base pairing occurs during transcription, early structural states can govern RNA processing events and d...

We are happy to share the development of Co-transcriptional Structure Tracking by @leoschaerfen.bsky.social, which measures RNA structure formation during its synthesis in vivo. We are excited to discover the activity of helicases on nascent rRNA!
www.biorxiv.org/content/10.1...

A pair of graphs I think about a lot. On the topic of pooled CRISPR screens, the left is "replicate correlation" when simply examining the abundance of guide RNAs, i.e. log-normalized read counts. On the right is taking those same data and subtracting from a common starting point, i.e. pDNA.

I know the feeling. ;)
Thank you!

You remember correctly. 😊

Congrats AND happy birthday, Jacki!