Our paper on aneuploidy driver identification just published in @cp-cellreports.bsky.social. Great work by Ron Saad, jointly supervised by the Shamir and Ben-David labs!

www.cell.com/cell-reports...

Thank you #SchmidtSciences for this amazing opportunity!

2/2 A great opportunity to thank my supporting mentors, inspiring collaborators and fantastic team members (past&present) — who make scientific discovery both possible & fun! 😊

1/2 Not a good time for celebrations — the war in Gaza must end NOW!

Nonetheless, I’m happy to share that I’ve been promoted to Full Professor at TAU!

Just as I’m about to start my Sabbatical with @kopslab.bsky.social & @renemedema.bsky.social in Utrecht 🇳🇱.

Happy to share our new comprehensive Review paper on the targeting of aneuploidy for cancer therapy. Just published in @cp-trendscancer.bsky.social.

The @embo.org #chromoploidy2025 is over. It was an amazing workshop organized by a perfect match of scientists and friends @mcclellandlab.bsky.social @bendavidlab.bsky.social @stesantaguida.bsky.social @foijer-lab.bsky.social, Elsa Logarinho, Caroline Audouin and myself

Chromosome Segregation and Aneuploidy Aneuploidy is a hallmark of cancer and developmental disorders such as Down syndrome. Understanding how cells accomplish faithful chromosome segregation and how chromosomal instability (CIN) impacts …

Excited to get the #EMBOChromoploidy meeting started! 3 days of fantastic science and fun in beautiful Stresa are beginning now!

meetings.embo.org/event/25-ane...

We have such an exciting program and speakers for our annual #EACR congress 🤩

Thanks to the many, many researchers who already submitted abstracts - and don't forget this week's March 6 abstract deadline ⏰ if you also want to join us in beautiful Lisbon!

2025.eacr.org

@helloeacr.bsky.social 🧪🔬⚕️

Happy to share our new preprint, in which we systematically
Identify and prioritize candidate drivers genes that underlie recurrent chromosome-arm losses!

www.biorxiv.org/content/10.1...

Opinion | American Science is Under Attack (Gift Article) The Trump administration hobbles research and endangers the public health.

American science is under attack

Opinion piece by Dr Harold Varmus, Nobel Prize winner, former director of the #NIH and the #NCI 🧪

“Perhaps what’s most disheartening is what feels like the absence of widespread opposition to this unraveling”

www.nytimes.com/2025/02/14/o...

A compendium of Amplification-Related Gain Of Sensitivity genes in human cancer - Nature Communications In cancer, the impact on cellular fitness of copy-number gains affecting collaterally-amplified genes remains poorly understood compared to oncogenes. Here, the authors integrate genomic data from tum...

So excited to see our paper describing the class of ARGOS genes in cancer out in @naturecomms.bsky.social! 🤩
www.nature.com/articles/s41...
A giant effort led with @ms01.bsky.social and executed under the mentorship of @bendavidlab.bsky.social @rameenberoukhim.bsky.social @foijer-lab.bsky.social
🧵👇:

High CDC20 levels increase sensitivity of cancer cells to MPS1 inhibitors | EMBO reports imageimageHigh CDC20 expression promotes aneuploid cancer cell sensitivity to spindle assembly checkpoint (SAC) inhibition by prolonging metaphase and reducing mitotic errors. These findings identify ...

www.embopress.org/doi/full/10....

Happy to share our new paper, published in @emboreports.org, in which we identify CDC20 as an important determinant of the cellular response to SAC inhibition. close collaboration with the @foijer-lab.bsky.social.
Kudos to Linoy, Siqi and Lin for spearheading this study! 👏
Link in 1st comment 😊

Abstract submission and registration date coming up soon at the end of Jan!

Targeting RNA and Protein Turnover in Aneuploid Cancers Summary:. Aneuploidy, an imbalance in chromosome number, is a hallmark of human cancers with chromosomal instability, and it remains a major therapeutic challenge. In this issue, Ippolito and colleagu...

Great to see our joint study with @stesantaguida.bsky.social published in this month’s issue of Cancer Discovery:
aacrjournals.org/cancerdiscov...

With a super-kind Research Highlight written by Sam Bakhoum:

Congratulations, what a beautiful work! 👏🎊

Join us in beautiful Stresa for this EMBO meeting, co-organized by @mcclellandlab.bsky.social, @foijer-lab.bsky.social, @stesantaguida.bsky.social, Daniele Fachinetti, Elsa Logarinho and myself.