Hans Oh

Building off of this work, we also disclose the discovery of a new chemical probe for the chikungunya nsP2 helicase (pubs.acs.org/doi/10.1021/...). It was an absolute pleasure to be a part of these projects with my amazing co-workers!

Identification of Direct-Acting nsP2 Helicase Inhibitors with Antialphaviral Activity Alphaviruses are mosquito-borne RNA viruses that pose a significant public health threat, with no FDA-approved antiviral therapeutics available. The nonstructural protein 2 helicase (nsP2hel) is an en...

Excited to present our lab's work on identifying new nsP2 helicase inhibitors with antiviral activity against chikunguya (pubs.acs.org/doi/10.1021/...)

Identification of Direct-acting nsP2 Helicase Inhibitors with Anti-alphaviral Activity Alphaviruses are mosquito-borne RNA viruses that pose a significant public health threat, with no FDA-approved antiviral therapeutics available. The non-structural protein 2 helicase (nsP2hel) is an e...

Check out our new pre-print on the discovery of nsP2 helicase inhibitors! #chembio #medchem www.biorxiv.org/content/10.1...

Structural insights into human brachyury DNA recognition and discovery of progressible binders for cancer therapy - Nature Communications This study describes structures of the transcription factor brachyury revealing the mechanism of DNA recognition. They identify fragments using X-ray fragment screening and optimize these into potent ...

Happy to see our story on brachyury published in Nature Communications! We use crystallographic fragment screening to identity multiple fragment hits for potential inhibitor and degrader development. doi.org/10.1038/s414...