Marco Sciacovelli

Good Sunday, all. What a great week for #cancermetabolism and #mitochondrialbiology. Find here a selection of groundbreaking discoveries: biomed.news/bims-camemi/... @biomednews.bsky.social #keepreading

"Trying to define yourself is like trying to bite your own teeth."-Alan Watts

FOXO1 links KRAS G12D and G12V alleles to glutamine and nitrogen metabolism in colorectal cancer | EMBO reports imageimageKRAS mutations at codon 12 induce profound metabolic changes in colorectal cancer cells. These oncogenic mutations promote FOXO1-dependent glutamine and nitrogen recycling, uncovering a vuln...

Great work from Suzan Ber and Alessandro Esposito regarding the metabolic reprogramming driven by different KRAS mutation in colorectal cancer. Thank you for involving me in this cool project! www.embopress.org/doi/full/10....

Accumulation of succinate suppresses de novo purine synthesis through succinylation-mediated control of the mitochondrial folate cycle The de novo purine synthesis pathway is fundamental for nucleotide production, yet the role of mitochondrial metabolism in modulating this process rem…

Excited to share our latest work out today in @cp-molcell.bsky.social, revealing a molecular link between succinate dehydrogenase and purine synthesis, connecting two fundamental metabolic pathways. Huge congratulations to the first author, Mushtaq Nengroo! www.sciencedirect.com/science/arti...
!

Metabolites in the extracellular tumor microenvironment and the shaping of macrophage function It has been a century since it was discovered that cancer cells have a distorted metabolism compared to healthy cells and tissues. It is now universal…

very nice review about how metabolic changes in the tumour microenvironment affect macrophage function: www.sciencedirect.com/science/arti...

Thank you @frances-turrell.bsky.social for a fantastic seminar!

Distinct metabolic and genetic alterations in tumors from early-onset versus late-onset colorectal cancer Early-onset colorectal cancer (EO-CRC) occurring in individuals under age 50 is rapidly increasing globally, while the incidence of late-onset colorec…

www.sciencedirect.com/science/arti...

Inhibition of HDAC6 alters fumarate hydratase activity and mitochondrial structure - Nature Communications Here they show that HDAC6 inhibition regulates fumarate hydratase (FH), disrupts mitochondria, increases fumarate, and causes cancer cell death. This suggests that HDAC6 inhibition could be a strategy...

nteresting paper showing how HDAC6 interacts and regulates fumarate hydratase (FH) affecting mitochondrial structure www.nature.com/articles/s41...

Succinate preserves CD8+ T cell fitness to augment antitumor immunity How various tumoral metabolites impact antitumor T cell immunity is an area of active research. Ma et al. demonstrate that succinate enhances mitochondrial fitness and induces epigenetic reprogramming...

Succinate preserves CD8+ T cell fitness to augment antitumor immunity: Immunity www.cell.com/immunity/ful...

Silencing mitochondrial gene expression in living cells Mitochondria fulfill central functions in metabolism and energy supply. They express their own genome, which encodes key subunits of the oxidative phosphorylation system. However, the central mechanis...

Silencing mitochondrial gene expression in living cells | Science www.science.org/doi/10.1126/...

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Good Sunday all! A great selection of papers in #cancermetabolism and #mitochondrialbiology is waiting for you! Loads of cool science!! biomed.news/bims-camemi/... @biomednews.bsky.social #keepreading

"You are the sky. Everything else—it’s just the weather."
Pema Chödrön

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Good morning all! There are some wonderful papers in #cancermetabolism and #mitochondrialbiology in this curated issue! Don't miss it, find it here: biomed.news/bims-camemi/... @biomednews.bsky.social
#keepreading

"When you argue with reality, you lose, but only 100% of the time." -Byron Katie

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Good Sunday, all! There are huge discoveries in this curated summary of papers in #cancermetabolism and #mitochondrialbiology. Don't miss it! Find it here: biomed.news/bims-camemi/... @biomednews.bsky.social #keepreading

"The quieter you become, the more you can hear."-Ram Dass

This week you can join our seminar online @livuni-ismib.bsky.social please check emails for Zoom link Friday

20th June 2025, 11am – 12pm.

Guest Speaker – Max Mazzone
Title – “Harnessing tumor metabolism to overcome immunosuppression”
Host – @mcschmid.bsky.social
Location – Zoom

Derepressing nuclear pyruvate dehydrogenase induces therapeutic cancer cell reprogramming Zhao et al. uncovered a nuclear-restricted acetyl-CoA regulatory mechanism where nucleus-localized pyruvate dehydrogenase complex (nPDC) is constitutively bound and repressed by nuclear protein ELMSAN...

Derepressing nuclear pyruvate dehydrogenase induces therapeutic cancer cell reprogramming: Cell Metabolism www.cell.com/cell-metabol...

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Good morning, all. Science keeps making excellent progress. Check the curated summary of papers in #cancermetabolism and #mitochondrialbiology here: biomed.news/bims-camemi/... @biomednews.bsky.social #keepreading

The boundary to what we can accept is the boundary to our freedom.
Tara Brach

Impact of physiological media on acute myeloid leukemia bioenergetics and cell proliferation - Cancer & Metabolism Increasing emphasis has been placed on improving the physiological relevance of cell culture media with formulations such as Human Plasma-Like Medium (HPLM). Given that shifts in mitochondrial metabol...

cancerandmetabolism.biomedcentral.com/articles/10....

Pyruvate metabolism enzyme DLAT promotes tumorigenesis by suppressing leucine catabolism Pyruvate and branched-chain amino acid (BCAA) metabolism are pivotal pathways in tumor progression, yet the intricate interplay between them and its i…

Very interesting work about how DLAT suppresses leucine catabolism via acetylation of AUH, ultimately favouring activation of mTOR and hepatic cancer
www.sciencedirect.com/science/arti...

Interested in the interplay between histone supply, epigenetics and cancer biology? This research intensive Masters (MRes) course at the University of Liverpool could be for you! Apply by 29th August 2025. www.liverpool.ac.uk/courses/biol...

Cross-organ metabolite production and consumption in healthy and atherogenic conditions An atlas mapping organ-specific metabolite production and consumption across various pathophysiological states in pigs shows impaired metabolic activity across organs by a Western diet or hypercholest...

Cross-organ metabolite production and consumption in healthy and atherogenic conditions: Cell www.cell.com/cell/fulltex...

Ever wondered which method to use to infer kinase activities from phosphoproteomics data? 💻💭Our revised comprehensive evaluation of kinase activity inference tools, done in collaboration with the Zhang lab @bcmhouston.bsky.social, is now out @natcomms.nature.com 🔬 tinyurl.com/4twuc6z4

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Good Sunday all. Science keeps on delivering beautiful discoveries despite all. Check the curated summary of papers in #cancermetabolism and #mitochondrialbiology here: biomed.news/bims-camemi/... @biomednews.bsky.social #keepreading

The time you enjoy wasting is not wasted time.
Bertrand Russell

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Good morning all! Another week has passed, multiple groundbreaking discoveries were made. Don't miss them, find them here: biomed.news/bims-camemi/...
@Bims_BiomedNews #readingtime

And what importance do I have in the courtroom of oblivion?

Pablo Neruda

Gang of 3: How the Krebs cycle-linked metabolites itaconate, succinate, and fumarate regulate macrophages and inflammation The Krebs cycle intermediates itaconate, succinate, and fumarate act as immunometabolites to regulate macrophage immune responses. This review highlights how these metabolites influence cytokine produ...

Very nice review about the role of TCA cycle-linked metabolites in regulating the functionality of macrophages
www.cell.com/cell-metabol...

Keeping a Close Eye on Cancer To understand most stories you should start from the beginning. We’ll explore how some cancers form, whether the gut microbiome could revolutionise the way…

Pint of Science featuring some of staff members:

"Keeping a Close Eye on Cancer"

Keep a look out for tickets (currently sold out!!)

@paulatherton.bsky.social

pintofscience.co.uk/event/keepin...

We have an exciting 2 year postdoc position available in our department in the lab of Marisa Merino - please see advert attached!

Please contact Marisa for more details!

Repost and share as you wish!

A nuclear branched-chain amino acid catabolism pathway controls histone propionylation in pancreatic cancer Branched-chain amino acid (BCAA) catabolism contributes prominently to the TCA cycle in the healthy pancreas but is suppressed in pancreatic ductal adenocarcinoma (PDA). The impact of this metabolic r...

Very cool work about the role of the branched-chain amino acids in regulating transcription in pancreatic cancer via histone propionylation
www.biorxiv.org/content/10.1...

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A belated weekly issue of papers in #cancermetabolism and #mitochondriabiology is ready for you! Check it out here: biomed.news/bims-camemi/... @biomednews.bsky.social

"You have to do nothing to be who you are. Nothing at all."
-H. W. L. Poonja

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Good Sunday, all! Another week, another set of massive discoveries in #cancermatabolism and #mitochondrialbiology! Find them here:

biomed.news/bims-camemi/...

@biomednews.bsky.social #keepreading

Be kind, for everyone is fighting a hard battle.
John Watson

This week @msciacovellilab.bsky.social and @drlornayoung.bsky.social provide an Undergraduate-style lecture to 60+ students visiting from the local region.

All students are on the Liverpool Scholars Programme, in partnership with Widening Participation 🎉