Zara was a great inspiration and mentor... Its really sad the excellent often leave us too soon... You will be missed Zara ๐
Zara was a great inspiration and mentor... Its really sad the excellent often leave us too soon... You will be missed Zara ๐
I worry that not enough of a big deal is being made about how long-term the devastation of these budget cuts to our scientific and health agencies will be, beyond the absolute ruin they will cause in the acute period.
but how exactly cells 'decide' to release AA in this context is still unexplored territory to us! As for channels and pumps, everything revolves around calcium as a necessary part of signaling, but other ions fluxes like potassium and sodium might help control this process too!
Hi! So we think the primary signal carrier between cells here is LTB4 (lots of literature on how this lipid is involved in neutrophil chemotaxis and crosstalk), however what triggers these waves is unclear. Our current work indicates that arachidonic acid release is a key wave 'initiation' cue 1/
The world we are entering with public funding being ripped to shreds (or doled out as political favor) is a world *no one* should want to live in. Things like what we did here wouldn't have been possible with a profit motive. Most creative, risky and fundamental research isn't.
Thanks @c0nc0rdance.bsky.social for this thread :) Wanted to amplify this part because its been on my mind a *lot* lately.
Public researchers work tirelessly (for limited pay) to create information for *everyone's* benefit. Attacking the NIH, NSF and other public funders hurts *all* of us...
This is really really beautiful data! I love watching these videos, must be a great problem to study!
Id love to join this list too! Hopefully will have a lot more live imaging to post soon~
Doing my best to make sure this page is about cool microscopy and not my current postdoc search status... ๐
Just swam over to Bluesky and decided to dip my fin in the water. I am a Postdoc in the Weinstein lab and currently on the faculty job market. I developed an injury system to study cutaneous wound healing in adult zebrafish. Check out my movie showing neutrophil recruitment after injury.
This is really really cool~! Do you know if adult zebrafish can be imaged like this but using the laser injury technique to get neutrophils to swarm? I didn't even know adult zebrafish could be used like this! ๐คฉ
The purple-yellow colors are a calcium dye! When a cell turns bright yellowish, it means its been activated (at least as far as calcium signaling goes)
I wish~ 60x water with a Crest spinning disk system!
Just because its fun~ This is one of my favorite videos I've taken in my PhD! Here is 60x imaging of neutrophils swarming to attack yeast targets in blue :)