Christl Gaubitz

Open / closed chromatin in Asgard archaea with glowing interacting residues

Open / closed chromatin in Asgard archaea

Last week, the Dodonova lab published a fascinating paper on chromatin structures in Asgard archaea, microbes thought to be the closest relatives of complex life.

Asgard histones can wrap DNA into a “closed” form shared across archaea, and an “open” form similar to eukaryotic cells #sciart #blender

We are hiring a postdoc! 🧪
▶️ Project: nucleotide metabolism (genomics & biochemistry)
▶️ Start date: spring 2026 (flexible)
▶️ More info and application: tinyurl.com/3kjrbb2x
Please share 🌏

@fbm-unil.bsky.social @dib-unil.bsky.social @unil.bsky.social @snsf.ch

Repair of DNA double-strand breaks leaves heritable impairment to genome function Upon DNA breakage, a genomic locus undergoes alterations in three-dimensional chromatin architecture to facilitate signaling and repair. Although cells possess mechanisms to repair damaged DNA, it is ...

𝗖𝗮𝗻 𝗰𝗲𝗹𝗹𝘀 𝗲𝘃𝗲𝗿 𝘁𝗿𝘂𝗹𝘆 𝗿𝗲𝗰𝗼𝘃𝗲𝗿 𝗳𝗿𝗼𝗺 𝗗𝗡𝗔 𝗱𝗮𝗺𝗮𝗴𝗲?Excited to share our new study “Repair of DNA double-strand breaks leaves heritable impairment to genome function”, revealing DNA repair’s hidden cost, out now @science.org tinyurl.com/5n6zw3ye. Led by @sbantele.bsky.social and Jiri Lukas.🧵👇1/n

DNA as ropes, organized in nucleosomes while interacting with a donut-shaped protein.

DNA represented as spheres sitting on an image of the crystallographic data obtained by Rosalind Franklin.

DNA as ropes, organized in nucleosomes while interacting with proteins.

Different visual representations of DNA

Check out some of my illustrations featuring DNA that is, actually, structurally accurate.
Whilst color is absent at the nanoscale, I choose it to highlight the form and function.
These illustrations are grounded in structural data.
#blender3d #sciart #DNA #scicomm

See our paper “Mechanism of trinucleotide repeat expansion by MutSβ-MutLγ and contraction by FAN1”. Using biochemistry, we show how DNA incisions by the MutLγ nuclease can lead to expansions, and how expansion is prevented by FAN1. Well done Issam and Valentina!

www.nature.com/articles/s41...

A blobby structure cut open showing its contents which are hélices and loops and light emitting spheres in the middle. This all depicts VPS45 protein

A conglomerate of lipid molecules forming a wall and separating two spaces with different contents

A space-like scene showing a sphere or vesicle about to be hooked by a multi subunit protein complex

Bringing invisible ideas to life.

#sciart #blender3D #illustration

*illustrations created for Mary Munson’s Lab website at UMass Chan Medical School*

Love the white clay version 🤍
#sciart #blender3d

DDIAS is a single-stranded DNA-binding effector of the TOPBP1-CIP2A complex in mitosis DNA double-strand breaks and unresolved DNA replication intermediates are particularly dangerous during mitosis. Paradoxically, cells inactivate canonical DNA repair mechanisms during chromosome segre...

Excited to share our lab’s latest preprint! We identify DDIAS as a novel single-stranded DNA-binding component of the TOPBP1–CIP2A complex, which acts in a mitotic DNA damage response pathway to protect chromosome integrity. Short summary below, and read it here: www.biorxiv.org/content/10.1...

Yadav, Jadhav, @hanasedlackova.bsky.social et al present a novel cell-permeable biotin-HaloTag ligand. The reported ligand expands the HaloTag toolbox by enabling in vivo labeling & providing capabilities for efficient affinity capture of protein variants from live cells rupress.org/jcb/article/...

Proud to share our first lab pre-print: “SND3 is the membrane insertase within a fungal multipass translocon” where @tzujingyang.bsky.social solved the structure of a ribosome-associated SND3-translocon complex involved in ER membrane protein insertion ➡️ doi.org/10.1101/2025...

Check out the paper led by Dr. Helen Findlay @plymouthmarine.bsky.social 🧪🌊🦑

#OceanAcidification : Another Planetary Boundary Crossed
doi.org/10.1111/gcb....

hey, that's me!

Excited to share our new pre-print. Direct, ensemble FRET assays developed by our lab reveal that assembly of Rad51 filaments at stalled replication sites via RPA/Rad51 exchange causes complete & irreversible PCNA unloading. Big implications for interplay between human DNA damage tolerance pathways

Local SUFS Events Stand Up for Science is officially supporting rallies in Washington DC and 31 other cities around the country. This means that a confirmed site leader—backed by our core team—is actively organizing…

Hey #Geneva, stand up for science today at noon!

Join me & Vice Rector Sébastian Castelltort (University of Geneva) for a walk-out at the CMU (or go to Campus Biotech at 11:30, they're having one too)!
#unige
#standupforscience
#MedSky #IDSky #academicsky
standupforscience2025.org/local-event-...

Nipah virus G protein with 16813 ligands (mostly waters) mapped from similar structures.

ChimeraX can run Foldseek to find similar structures, such as distantly related homologs, and analyze the results, for example, mapping all ligands onto your query structure. Here are ligands mapped onto Nipah virus G protein. www.rbvi.ucsf.edu/chimerax/dat...

Predictomes, a classifier-curated database of AlphaFold-modeled protein-protein interactions Schmid and Walter train a classifier that discerns functionally relevant structure predictions in proteome-wide protein-protein interaction (PPI) screens using AlphaFold-Multimer, and they use this co...

Very excited to share that my thesis work is out in Molecular Cell! We trained a Structure and Omics informed Classifier (SPOC) to score binary AlphaFold multimer (AF-M) predictions by structural quality and consistency with experimental omics datasets. www.cell.com/molecular-ce...

Sign the Petition Petition to Reverse the NIH Indirect Cost Cap (NOT-OD-25-068)

Signed. You should too.

www.change.org/p/petition-t...

I will close the letter for signatures at 17:00 today (UK time). Last chance to voice your support before this evening's meeting of the Royal Society.

Can AlphaFold refine structures for X-ray & Cryo-EM/ET data? Now it can! Great collab with @moalquraishi.bsky.social and @randyjread.bsky.social led by @alisiafadini.bsky.social and @minhuanli.bsky.social. 🧵below. Code to follow...

CT friends! We are standing up for Science on March 7th in Hartford!
Stay tuned for details —
@centromellone.bsky.social
@davidbreslowlab.bsky.social
@gregggonsalves.bsky.social @luskinglab.bsky.social

Tomorrow is the last day to submit your application for the INTERACT PhD Programme!
Apply now: https://buff.ly/4hj1bGh

Science needs more bridges to the global south 🌍! Do share this great opportunity we are offering @mpifkf.bsky.social! Last year was a great success: www.fkf.mpg.de/8350642/2024...
We are so excited to be able to offer it again

Science benefits from diversity!

#STEM #Chemsky #SciSky #PhySky

From a journalist friend: Just spreading the word. The CDC is purging data, so people should archive their favorite CDC datasets today, namely ones around race/ethnic diversity, LGBTQ, and reproductive health. Also health data involving climate. The youth risk behavior survey has already gone down.

This is legit - the organizers (including unions) are organizing. When I ask those in the know what we can do that will actually matter, the answer includes collective action of this type.

I'm joining @nancykanwisher.bsky.social and all the others for this Thurs 3p ET effort. I hope you do too!

we are recruiting a postdoc to work on a collaborative project with the lab of Nynke Dekker in Oxford @nynkedekkerlab.bsky.social. Please RT www.hubrecht.eu/job/postdoc-...

@professorantony.bsky.social and our teams are excited to share new preprint on RPA phosphocode and G2-M transition. Thanks to the efforts of lead authors -Poonam Roshan and Vikas Kaushik!

🥼We are recruiting!
Exciting opportunity for a Postdoctoral Research Associate/Postdoctoral Research Fellow to join the newly-funded MRC Programme Fungi-CARE (Combinations Against Resistance Emergence).
Find out more and apply here: jobs.exeter.ac.uk/hrpr_webrecr...

Our paper on computational design of chemically induced protein interactions is out in @natureportfolio.bsky.social. Big thanks to all co-authors, especially Anthony Marchand, Stephen Buckley and Bruno Correia!

t.co/vtYlhi8aQm

If you are interested in nucleic acid structures- G4 and beyond. Here is the flyer for the next webinar series, talks range from physics to chemistry up to biology and Medicine

Excited to share James Jusuf's preprint:

By integrating Micro-C with SuperRes Live-Imaging we can calibrate genomics&imaging to perform absolute quantification of looping (e.g. this loop is present 3%)

We quantify mESC 36k loops: <loops> are generally rare (2.3%)

www.biorxiv.org/content/10.1...