@doriswang
Neurosurgeon-scientist studying how brains walk the walk. Neural interfaces, devices, oscillations, and toddler chase dynamics. Balancing beta bursts and bedtime stories. 📍UCSF | 🧠⚡️🚶🏻♂️ | Views my own (but likely statistically significant)
Here, we use totally implanted electrodes while they are carrying out daily activities at home to decode whether someone is walking. Using an implanted stimulator, we can use this signal to detect these events in real time, paving the way for movement state- driven adaptive DBS!
Super excited to share our new paper: At-home movement state classification using totally implantable cortical-basal ganglia neural interface | Science Advances www.science.org/doi/10.1126/...
High-intensity focused ultrasound (HIFU) is an incision-less surgical procedure used to treat essential tremor by lesioning the brain pathway involved with tremor generation. @ucsfhealth.bsky.social neurosurgeon @doriswang.bsky.social explains that this leads to lasting tremor reduction.
Great talks and even more interesting and engaging discussion! Fantastic start to the think tank!
Congratulations!!!!!🎉🍾🎊
This work was led by the amazing former postdoc Ken Louie, and an all star research team and collaborators to make it happen! #aDBS #Parkinsons #gait
We tested the effects of adaptive DBS both in clinic and at home and found that aDBS improves gait symmetry and variability in patients with Parkinson’s disease! Providing an exciting and promising therapy to restore gait functions.
Here, we use chronically implanted bidirectional DBS devices connected to pallidal leads and cortical ECoG strips to 1) capture biomarkers of leg swing during natural walking 2) use these biomarkers to rapidly change stimulation amplitudes during each gait cycle in an embedded device.
Super proud and excited to share our preprint.
www.medrxiv.org/content/10.1...
Thanks you so much for inviting me to be a part of this fantastic conference! I learned so much and am beyond excited for our field!
We’re honored to be named among the top two neurosurgery programs nationwide and the Best in the West by @usnews.com! 🎉 It's a privilege caring for our patients and their families, and we thank our entire team for hard work and dedication. @ucsfhealth.bsky.social www.ucsfhealth.org/lp/us-news-2...
Graphic that depicts an overview of the study in which UCSF researchers modeled and optimized DBS settings to improve walking in patients with Parkinson's, identifying key insights abut the neurophysiology of walking along the way.
A new study led by @doriswang.bsky.social's lab developed a systematic way to quantify key aspects of gait in patients with #Parkinsons and used machine learning to identify personalized deep brain stimulation (DBS) settings to improve walking: www.ucsf.edu/news/2025/07...
@ucsfhealth.bsky.social 🧠📈
Lab party! Thanks to all these amazing, hardworking, compassionate geniuses for making science fun!
Can we reboot walking after Parkinson's disease DBS?
Can AI teach deep brain stimulation devices to help people 'walk the walk?' A new study by Wang says MAYBE. Using personalized data-driven models, they optimized DBS for walking.
@parkinsondotorg.bsky.social #parkinson @ucsfhealth.bsky.social
Very excited to share our newest publication on identifying neurophysiological signatures of improved gait using bidirectional DBS devices!
Interested in human brain function and neuroimaging during natural real-world activities? Learn more from our amazing speakers and present your own work at the Neuroscience of the Everyday World Conference. Registration & abstract submission is now open: neuroscienceeverydayworld.org/conference-2...
Very much looking forward to our speakers: @maryamshanechi.bsky.social, @hugospiers.bsky.social, Marom Bikson, @jenpitt.bsky.social, Mary Czerwinski, @peabody124.bsky.social, @dpferris.bsky.social, @sladouce.bsky.social, Matthew Rizzo,
@c-rothkopf.bsky.social, @doriswang.bsky.social, Ying Choon Wu
Very excited to share our latest preprint. Using implanted DBS devices with at home wearable monitors, we were able to identify gait state in the natural environment based on cortical and basal ganglia neural signature: www.medrxiv.org/content/10.1...
To the stranger who paid for our lunch at Kona airport because I didn’t have a credit card on me (getting too used to tap to pay), thank you from the bottom of my heart and my toddlers’ growling stomachs. I will always remember your kindness and pay it forward! #humanity #payitforward #kindness
It suggests that abnormal pallidal outflow and synchronization between the pallidum and motor cortices may be a pathophysiological mechanism underlying disordered postural response in Parkinson's disease.
Our results provide evidence for a model where synchronized premotor and motor cortical activities transiently couple with the globus pallidus to regulate the timing of postural responses, and local pallidal activity regulate the amplitude of postural changes during gait initiation.
We found distinct patterns of oscillatory changes that occur in the pallidum and motor cortex, and found that while pallidum gamma power is predictive of the scaling of gait initiation, pallidal M1, and premotor-M1 low frequency coherence is predictive of the timing of weight shift
Excited to share our new preprint. We recorded field potentials from the motor/premotor cortices and pallidum of people with Parkinson’s disease as they performed a gait initiation task to understand the cortico-pallidal network dynamics that underlie this action: www.medrxiv.org/content/10.1...
Completed our 100th focused ultrasound treatment! It truly takes a village and a collaborative effort to make it possible. Go team and here’s to many more!
#fus #hifu #neurosurgery #tremor
Good to be back
Masters debate in a chateau! Amazing talks, colleagues, and inspiring innovation. So great to be back in Paris even just for a day!
🌞🏝️🏄🏻♀️❤️
First but not certainly my last Waymo ride. #waymo #robotcar
Weekend vibes
