Thomas Elbenhardt Jensen

Exofacial Epitope–Specific Antibodies Detect GLUT4 Translocation in Adult Human, Rat, and Mouse Skeletal Muscle Skeletal muscle glucose transporter 4 (GLUT4) translocation to the plasma membrane determines glucose uptake in response to insulin and exercise and is dis

Our latest work showing that GLUT4 exofacial antibodies can measure translocation in humans and rodent skeletal muscle fibers and is impaired in TBC1D4 KO rats despite rescued GLUT4 expression. Congrats Kaspar and co-authors. DM me for open access version:
diabetesjournals.org/diabetes/art...

PhD fellowship in Molecular Exercise Physiology Project on Skeletal Muscle Hypertrophy Mechanisms in Mice The project: The Section for Human and Molecular Physiology invites applicants for a three-year PhD fe

PhD position available in my group at UCPH. Focus on delineating novel mechanisms of muscle hypertrophy using cutting edge models and analyses💪. Deadline Jan 29, 2026.
Apply: candidate.hr-manager.net/ApplicationI...

Muscle‐specific AXIN1 and AXIN2 double knockout does not alter AMPK/mTORC1 signalling or glucose metabolism Abstract figure legend This study investigated the role of AXIN1 and AXIN2 in regulating skeletal muscle AMP-activated protein kinase (AMPK) and mechanistic target of rapamycin complex 1 (mTORC1) sig....

In our latest paper, we show that inducible sk. muscle AXIN1 /2 double KO have normal AMPK, mTOR and glucose uptake regulation, questioning previously proposed dependencies on this scaffold protein. Thanks to all co-authors for their contributions
physoc.onlinelibrary.wiley.com/doi/10.1113/...

NAD depletion in skeletal muscle does not compromise muscle function or accelerate aging Nicotinamide adenine dinucleotide (NAD) is a ubiquitous electron carrier essential for energy metabolism and post-translational modification of numero…

Latest from Jonas Treebak and team @cbmr.science

NAD depletion in skeletal muscle does not compromise muscle function o... www.sciencedirect.com/science/arti...

Check out our latest paper challenging the long-standing belief that insulin elicits a transient H₂O₂ production. New insights into skeletal muscle redox signaling and insulin action 🤩

Revisiting Insulin-Stimulated Hydrogen Peroxide Dynamics Reveals a Cytosolic Reductive Shift in Skeletal Muscle The intracellular redox state is crucial for insulin responses in peripheral tissues. Despite the longstanding belief that insulin signaling increases…

Our new paper in Redox Biol showing that insulin stimulation of skeletal muscle surprisingly does not detectably increase the ROS H2O2 using state-of-art methods in different models including humans, but in fact causes a selective reductive shift - enjoy
www.sciencedirect.com/science/arti...

Exploring NADPH oxidases 2 and 4 in cardiac and skeletal muscle adaptations – A cross-tissue comparison Striated muscle cells, encompassing cardiac myocytes and skeletal muscle fibers, are fundamental to athletic performance, facilitating blood circulati…

“Exploring NADPH oxidases 2 and 4 in cardiac and skeletal muscle adaptations – A cross-tissue comparison” by @robertoandresmv.bsky.social, @musclebiology.bsky.social, @elbenhardt.bsky.social et al. (sorry if I do not find all of the #bluesky handles).

www.sciencedirect.com/science/arti...

3/17

🚨Paper Alert 🚨: PanK4 Identified as Regulator of Glucose and Lipid #Metabolism. A new study led by mkleinert.bsky.social‬ at our DZD-Partner #DIfE has identified PanK4 as a key regulator of energy metabolism in skeletal muscle. ⬇️ ⬇️ ⬇️ ⬇️

mTOR Ser1261 is an AMPK‐dependent phosphosite in mouse and human skeletal muscle not required for mTORC2 activity mTOR Ser1261 is an AMPK-dependent phosphosite in human and mouse skeletal muscle that responds to exercise but not insulin, plays an unclear role in mTORC1 regulation, and is not required for mTORC2 ....

Our new FASEBJ paper. We looked into mTOR Ser1261 phosphorylation in human and mouse muscle, proposed by Diane Fingar's lab to be first an Akt and then AMPK site regulating mTORC1 and 2 activity. Clearly AMPK site but impact on mTORC unclear in our hands faseb.onlinelibrary.wiley.com/doi/10.1096/...

Pantothenate kinase 4 controls skeletal muscle substrate metabolism - Nature Communications Here, Miranda-Cervantes et al. identified pantothenate kinase 4 (PanK4) as a key regulator of muscle metabolism. Deleting PanK4 impairs fatty acid oxidation and glucose uptake, leading to glucose into...

Curious about muscle metabolism? 🚴‍♂️ We reveal PanK4 as a conserved exercise target in muscle! 💪 PanK4 regulates lipid & glucose use likely via acetyl-CoA. We think PanK4 belongs alongside Akt, mTOR, AMPK, Rac1 & more as a key player in muscle energy homeostasis. #Metabolism #MyoBlue

Pantothenate kinase 4 controls skeletal muscle substrate metabolism - Nature Communications Here, Miranda-Cervantes et al. identified pantothenate kinase 4 (PanK4) as a key regulator of muscle metabolism. Deleting PanK4 impairs fatty acid oxidation and glucose uptake, leading to glucose into...

Pantothenate kinase 4 controls skeletal muscle substrate metabolism
www.nature.com/articles/s41...

A family of NADPH/NADP+ biosensors reveals in vivo dynamics of central redox metabolism across eukaryotes - Nature Communications This article presents NAPstars, a family of genetically-encoded biosensors that enable real-time monitoring of NADP redox dynamics across species. The sensors reveal robust NADP redox regulation, cell...

A new biosensor is born 👼
The NAPstar family of genetically-encoded sensors for live NADP redox monitoring🔋🪫

Jointly with the Morgan lab & @riemerlab.bsky.social we looked in vitro, in yeast, plants & mammalian cells 🧪🦠🧫🌱

Where to go next? @naturecomms.bsky.social
doi.org/10.1038/s414...

Tapping into data from Bluesky Altmetric has expanded its tracking capabilities by integrating data from Bluesky, the rapidly growing social media platform with over 24 million users.

🌟 ICYMI: Altmetric now tracks Bluesky mentions!

✔️ Comprehensive social media coverage
📊 Mentions reflected in your Altmetric score
🌐 Stay ahead in tracking research discussions

Your research is moving to new spaces—don’t miss a thing! Read more here: www.altmetric.com/bl...

#AcademicSky

Sex differences in skeletal muscle metabolism in exercise and type 2 diabetes mellitus - Nature Reviews Endocrinology This Review focuses on currently available literature describing sex differences in skeletal muscle metabolism in humans, as well as highlighting current research gaps within the field. These discussi...

New from Anna Krook and team. Biological sex differences in skeletal muscle metabolism and exercise adaptation in People with type 2 diabetes
#myoblue #exercise #metabolism
www.nature.com/articles/s41...

www.cell.com/cell-metabol...

Let’s try out this new platform by sharing our recent paper on the transcriptional signatures of individual muscle fibers following high-intensity exercise
#myoblue #myosky

journals.physiology.org/doi/abs/10.1...

A sketch poster illustrating an academic talk. 4 panels around a map of Antarctica, each panel with a character in it, four men and a dog, labelled the scientist, the doctor, the subject, the witness. Each includes some text about their experiences (e.g the dog says best trip ever!!! Lots of people to play with). There is a sketch of a woman bottom right (the speaker) and the logo of novo nordisk science cluster and www.EleonoraNigro.com

Neither the conference organisers nor the artist are (yet) on here but look at this amazing live drawn summary of my #MetabolismInAction paper by Eleonora Nigro #HistSTM #PolarHistory