King Lab at McGill University

Epigenetics: History, Molecules, and Diseases -- Book overview YouTube video by John Greally

I finally got around to putting together a quick overview of what my book is all about.

youtu.be/xPt1xy4_i-o?...

#epigenetics #epigeneticsbook #epigenome

Cross-presentation of dead cell-associated antigens shapes the neoantigenic landscape of tumor immunity - Nature Immunology Here the authors show DNGR-1 expressed by cDC1s promotes CD8⁺ T cell priming to cytoskeletal neoantigens from dying tumor cells, thereby shaping cancer immune visibility and tumor evolution through im...

@drjonlim.bsky.social & @reisesousalab.bsky.social show cDC1s & DNGR1 favor "tethered" neoantigens from F-actin proteins, trapping them in necrotic debris for better cross-presentation! Calls for prioritizing these neoantigens for cancer vaccine design #Immunotherapy www.nature.com/articles/s41...

My main PhD paper is finally out! 🎉

After ~5 years, it’s published today in 𝘕𝘢𝘵𝘶𝘳𝘦 𝘐𝘮𝘮𝘶𝘯𝘰𝘭𝘰𝘨𝘺.
@natimmunol.nature.com

It all started with an unexpected observation 🔍:
👉 Mice lacking the dendritic cell receptor DNGR-1 developed tumours earlier ⏩ and more frequently 📈 than wild-type mice.

1/11 🧵

Portrait of Marina Vance, a scientist, sitting in a Colorado grassland.

The @nytimes.com Lost Science series continues. Here's my Q&A with a scientist who was studying how wildfire smoke threatens human health when the EPA decided that her research was no longer a funding priority. Gift link: nyti.ms/4jhpw14

Canada Impact+ Research Chairs Competition McGill University, a world-renowned research intensive institution, invites applications for the Canada Impact+ Research Chairs (Impact+) Program, open to the rank of Associate or Full Professor. The ...

Incredible $10M opportunity for investigators to move to Canada.

www.mcgill.ca/research/res...

Need more info before signing petition for state-backed research institute? Get the full behind-the-scenes 🎞️ of how the Empire Biomedical Research Institute proposal came to be, what’s needed to move it forward, and how other states can follow suit: keypoint.keystonesymposia.org/home/shruti-...

Was a great year for our Centre and very much looking forward to developing new microbiome projects and collaborations in 2026!

Reaching maturity: Thymic γδ T cell differentiation in mice and humans γδ T cell differentiation into specialized effector subsets during both early life and adulthood is reviewed.

Reaching maturity: Thymic γδ T cell differentiation in mice and humans

#gdTcells

Today, we see the fruit of 5+ years of teamwork. We have built a map of the neutrophil compartment (mostly in mice - but also humans). It provides a biological structure that focuses on a single immune cell lineage to discover the many ways in which neutrophils "interpret" physiology.

Stroke scientists gather more evidence for presence of ‘gut-brain axis’ Research on mice by scientists at The University of Manchester has shed new light on why the guts’ immune system changes after a stroke and how it might contribute to gastro-intestinal problems.Publis...

www.manchester.ac.uk/about/news/s...

NYC Postdocs: Join us for our next Postdoc Night Science session to practice how to get new ideas using "puzzle-switching"! This time we're in Columbia U. on Dec 3 at 5pm.
Free registration: docs.google.com/forms/d/1onf... @stearnslab.bsky.social @kelseymonson.bsky.social @jaeseunghahn.bsky.social

Fecal exfoliome sequencing captures immune dynamics of the healthy and inflamed gut - Nature Biotechnology Profiling host RNA shed in feces reveals disease states in the gut.

Another banger from the @harriswang.bsky.social Lab this month!

“Fecal exfoliome sequencing captures immune dynamics of the healthy and inflamed gut” www.nature.com/articles/s41...

What an accomplishment Michele, congrats!!!!

So so grateful to all donors and to the fantastic TFRI team!

Junior Group Leader for RNA-Biology, RNA-Technology or RNA-Medicine (f/m/d) - Würzburg (Stadt), Bayern (DE) job with Helmholtz-Institut für RNA-basierte Infektionsforschung (HIRI) | 12844907 #RNAexcellence Junior Group Leader Positions (f/m/d) Job advertisement no.:   089/2025 Starting date:                  As soon as possible. The con...

🚨 A fantastic opportunity to join HIRI to start your research group on RNA Biology 👇 www.nature.com/naturecareer...

Microbiota promote enhanced CD39 expression in γδ intraepithelial lymphocytes through the activation of TCR and IL-15 signaling Intraepithelial lymphocytes expressing the γδ T cell receptor (γδ IEL) provide continuous surveillance of the intestinal epithelium. We report that mi…

📚NEW #gdTcell PAPER ALERT! 'Microbiota promote enhanced CD39 expression in γδ intraepithelial lymphocytes through the activation of TCR and IL-15 signaling' is now out in @mucosalimmunol.bsky.social! #gastrosky #GIsky #IBDsky Join us for a Bluetorial 🧵...

👇🏻👇🏻

Antigen-presenting cells as arbiters of mucosal tolerance and immunity Nature Immunology - Brown and colleagues review the heterogeneity of mucosal antigen-presenting cells that orchestrate T cell immunity to intestinal antigens.

Excited to share our review on Thetis cells and dendritic cells, and their roles in mucosal immunity and tolerance @natimmunol.nature.com rdcu.be/eLtB1

Home - Zwick Lab Our organs don’t just grow once – they grow with us. While some are more adaptable than others, many remodel throughout life to meet the body’s changing needs, from daily challenges to the extraordina...

The Zwick Lab website is live! 🔬🌀🌈
Check out our research and team at www.zwicklab.org

Group 3 innate lymphoid cell-derived CSF2 tunes homeostasis of tissue macrophages and neutrophils Mucosal surfaces are complex ecosystems that rely on continuous communication between host and the inhabiting microbiota to sustain immune balance and health. The vast complexity of microbial communit...

Group 3 innate lymphoid cell-derived CSF2 tunes homeostasis of tissue macrophages and neutrophils from @sltai.bsky.social @theonlylabever.bsky.social and colleagues: www.mucosalimmunology.org/article/S193...

Happy to share that my first first-authored paper is finally out in @mucosalimmunol.bsky.social in time for the long weekend!
This work would not have been possible without the current and past members of @theonlylabever.bsky.social
Check it out here:
www.sciencedirect.com/science/arti...

In our latest work we've explored associations between the fecal bile acid pool and helminth infection status in school aged children in Uganda. Have a read and see what we found!

Associations between helminth infection status and the composition and concentration of fecal bile acids in school-age children in Uganda - Scientific Reports Scientific Reports - Associations between helminth infection status and the composition and concentration of fecal bile acids in school-age children in Uganda

Delighted to share my latest publication as a PhD candidate in @drlarey.bsky.social’s lab at @uvicscience.bsky.social!
With our international collaborators we’re excited to share our findings on the associations between #helminths and fecal bile acids! 🪱

doi.org/10.1038/s415...

Immunotherapy researcher Miriam Merad from Icahn Mount Sinai says the reason that cancer research has slowed is because of funding issues, which is something taxpayers don’t have to accept.

“We fight for patients, we fight for science, and we have to fight for progress.”
#STATSummit

Awesome, congrats Marcel and team!!

Excited to see the PhD work led by Sarah Danchuk published today. Virulence hierarchies within the Mycobacterium tuberculosis complex. Thanks to all the authors and collaborators, and especially kudos to Sarah: www.pnas.org/doi/10.1073/...

Gut mucosal immune responses – Implications for celiac disease and food allergy The intestinal mucosa employs a diverse set of defense mechanisms—from mucosal barrier regulation to immunoregulatory pathways—to maintain homeostasis…

SMI member Valerie Abadie reviews gut mucosal immune responses and their implications for celiac disease and food allergy at Seminars in Immunology: www.sciencedirect.com/science/arti...

#SMIMemberPaper #MucosalImmunology #Immunology

Heterozygosity for Crohn’s disease risk allele of ATG16L1 promotes unique protein interactions and protects against bacterial infection ATG16L1T300A is associated with Crohn’s disease and causes immune dysfunction in mouse models, yet a plurality of humans are heterozygous carriers. Yao, Rudensky, et al. find that the ATG16L1 disease ...

Very cool paper from @cadwelllab.bsky.social showing a trade off between host defense and susceptibility to Crohn’s disease

Heterozygosity for Crohn’s disease risk allele of ATG16L1 promotes unique protein interactions and protects against bacterial infection: Immunity www.cell.com/immunity/ful...

Microbial metabolism of food allergens determines the severity of IgE-mediated anaphylaxis @biorxivpreprint.bsky.social
www.biorxiv.org/content/10.1...

Two group leader positions available in the broader areas of RNA science, RNA technologies, and RNA medicine. Attractive packages and a great environment. Come and join us at Helmholtz RNA Würzburg, Bavaria.