Genetic mutations found for young (<2 year old) dogs who form CaOx stones.
09.03.2026 13:37
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Genetic mutations found for young (<2 year old) dogs who form CaOx stones.
Frequency of cystine stones is increasing- likely due to recommendations to neuter later in life. Type III cystinuria is androgen dependent and neutering is generally curative.
Dogs and cats metabolize uric acid to allantoin, which is more soluble- hence why dogs and cats don’t have gout!
Eva Furrow discusses metabolism and genetics of urolithiasis. The SLC2A9 mutation associated with urate urolithiasis is linked to spot color. The dogs were bred for looks and resulted in nearly 100% penetration of the mutation in the breed line!
Modifications to the protocol- chemo now before radiation, reducing from 20 to 15 fractions of radiation had similar efficacy and less (18%) incontinence.
Permanent urinary incontinence was seen in 31% of dogs. Median time of onset was 2 months post radiation.
Dr. Nolan presents on radiation treatment of canine bladder cancer.
Gilvetmab is undergoing trials on canine bladder cancer. It may help evade the T-cell exhaustion occurring during chemotherapy.
For patients where surgery is an option (nontrigonal, no urethral or prostate involvement) partial cystectomy would be a great option. Since we often don’t dx UC until they are symptomatic, patient pop is skewed towards those with trigonal and distal lesions.
Since most bladder tumors express a BRAF mutation, directed therapy against BRAF has good PR & CR, but high frequency of cutaneous lesions secondary to upregulation of the targeted pathway.
Dr. Mastromauro reviews alternative therapies for canine bladder cancer.
Application of human treatment paradigm to canine bladder cancer.
So far a false positive hasn’t been identified for the BRAF mutation. All the dogs have had or later developed lesions found on US or cystoscopy. But use in the general dog population with a low incidence of bladder cancer is likely going to be low yield and have a low PPV.
Dr. Hess reviews immunotherapies for bladder cancer immunotherapy.
Using BRAF screening in asymptomatic high risk breeds could detect cancer a median of 149 days prior to the development of clinical signs.
Current performance of urine BRAF mutation testing in dogs to detect carcinoma: 85% sensitivity and 99.5% specificity
A single base pair mutation in BRAF is present in the vast majority (>95%) of canine bladder tumors. The same mutation is seen in some forms of human cancer.
Dr. Breen provides and update on molecular methods of bladder cancer detection in dogs. Very strong genomic associations are seen in dogs with urothelial carcinoma.
Outcomes with metastatic tumors are improved when pembrolizumab added to platinum chemo
Therapeutic options for patients who fail BCG treatment.
Intravesicular BCG has been standard for care for decades.
Dr. Aberna discusses the role of TURBT in treating bladder cancer. Outcome improves with instillation of chemo immediately after resection.
Excited to be at the 2026 ACVNU Lower Urinary Tract Symposium! Stay tuned for highlights!
I have to pull out the anatomy textbooks to remind myself what that weird spiral blood vessel is. Its an artery that seems to be heading for the left shoulder. Is that where they keep their second heart? Rabbits never stop amazing me.
Great to see #vetneph sneak into the NephMadness brackets!
ajkdblog.org/2026/03/01/n...
My band just released two tracks from our upcoming album. Check it out here; ligatures.bandcamp.com/album/2-song...
Our top trending #JAVMA article last week was "Use of a veterinary therapeutic renal diet in cats with early chronic kidney disease is associated with slower disease progression and improved survival": doi.org/10.2460/javm...
Retested the urine twice more- the pseudomonas wasn’t present in either. This dog has urothelial carcinoma so all samples were free catch. I suspect it was either contamination or maybe a weird lab error.
Recently discharged an otherwise healthy young cat with a creatinine of 21 for at home euthanasia.
So just keep the lilies out of the house if you have cats! Cats are drawn to the smells and colors of the lily plant- don't risk keeping one inside! Cats can't resist the temptation to rub their face on the flowers (ingesting pollen) or chew on the petals! #vetneph