Ute Häussler

‘Mini analysis’ misrepresents changes in synaptic properties due to incomplete event detection Abstract figure legend Summary of the study where simulated recordings (left) were used to characterise the effect of incomplete detection on mini (mPSC) analysis. Recording noise levels (red) determ...

Our paper on 'mini analysis' is now published in @jphysiol.bsky.social
If you are recording mPSCs or sPSCs, I hope this helps with analysis. Interpretation of these datasets is not as easy as it seems..!
Happy to discuss if you are interested
physoc.onlinelibrary.wiley.com/doi/10.1113/...

Cell-specific wiring routes information flow through hippocampal CA3 The hippocampus, critical for learning and memory, is dogmatically described as a trisynaptic circuit where dentate gyrus granule cells (GCs), CA3 pyr…

Our work looking into heterogeneous pyramidal neurons (PNs) in hippocampal CA3 is now online @cp-cellreports.bsky.social: www.sciencedirect.com/science/arti... With a pile of multicellular recordings from mouse CA3, we characterised the recurrent network at the single cell level...

Long-term hippocampal low-frequency stimulation alleviates focal seizures, memory deficits and synaptic pathology in epileptic mice Mesial temporal lobe epilepsy (MTLE) is a prevalent form of focal epilepsy characterized by seizures originating from the hippocampus and adjacent reg…

A new paper from the group is online: we show that longterm low-frequency stimulation alleviates seizures beyond stimulation periods and reverses epilepsy-associated synaptic alterations. #TrEPILab

www.sciencedirect.com/science/arti...

Looking forward to an exciting Spring Hippocampal Research Conference in Verona with @mbartos.bsky.social @olechsylte.bsky.social @federicotorelli.bsky.social and @ute-fr.bsky.social

Light-microscopy-based connectomic reconstruction of mammalian brain tissue - Nature A technique called LICONN (light-microscopy-based connectomics) allows mapping of brain tissue at synapse level and simultaneous measurement of molecular information, thus enabling quantification of c...

Incredibly impressive and powerful new method - connectomics with light microscopy! Congrats @mojtabart.bsky.social, Hans Danzl and team @istaresearch.bsky.social ! It works incredibly well - we will keep using this magic, and recommend you do too!

Spatiotemporal Patterns Differentiate Hippocampal Sharp-Wave Ripples from Interictal Epileptiform Discharges in Mice and Humans Hippocampal sharp-wave ripples (SPW-Rs) are high-frequency oscillations critical for memory consolidation in mammals. Despite extensive characterization in rodents, their application as biomarkers to ...

New preprint about SWRs, this time in HUMANS! 🤩 With @anna-maslarova.bsky.social and @JiyunShin, from @NYU, we’ve (i) developed a pipeline to analyze SWRs in intracranial EEG, and (ii) created ripmap, an open-source toolbox that allows versatile inspection and curation of events 🧵

Coordinated representational drift supports stable place coding in hippocampal CA1 The phenomenon of representational drift (i.e., changing neuronal tuning during repeated exposure to the same stimuli), is a fundamental paradox in neuroscience that raises the question how stable beh...

Stable maps from drifting neurons: CA1 solves the "representational drift paradox" through coordinated population dynamics.

New preprint w/ @antjekilias.bsky.social , Marlene Bartos and @jf-sauer.bsky.social showing that representational drift isn’t random—it’s structured to preserve information🧵👇

Are you interested in drifting place cells and the paradox of stable spatial maps? We have uploaded a new preprint: We find coordinated drifting in CA1.

Very happy about this collaboration w/ @olechsylte.bsky.social, Marlene Bartos and @jf-sauer.bsky.social

👇👇👇

#TrEPILab

Our new preprint on long-term low-frequency stimulation in MTLE is online. We show that LFS has lasting effects on seizures even during stimulation-free periods and induces ultrastructural changes at the PP synapse.

Dysregulation of Myelination in Focal Cortical Dysplasia Type II of the Human Frontal Lobe FCD IIa shows a normal radial myelin fiber pattern, thinner myelin sheaths and reduced myelin synthesis. FCD IIb has disorganized myelinated fibers, thicker myelin sheaths, more oligodendrocytes, and...

Under the christmas tree: our new paper on Focall Cortical Dysplasia just appeared in Glia

doi.org/10.1002/glia...

Human hippocampal CA3 uses specific functional connectivity rules for efficient associative memory Human hippocampal CA3 networks use sparse and broad synaptic connectivity, and their recurrent synapses employ reliability, precision, and long integration times to enhance memory capacity. Thus, the human hippocampus is distinct from both rodent counterparts and human neocortical circuits.

Is neuroscience research really working to understand the human brain? Or do we get lost in mouse cognition? I’ve asked myself this a lot since starting to work with human tissue. Our first Jonas Lab foray into untangling human hippocampal circuits is now online! www.cell.com/cell/fulltex... 1/a few

On my way to my first AES meeting. Exited for a lot of interesting epilepsy research!