@ymilaneschi
Clinical psychologist, psychotherapist and Associate Professor in Psychiatry & Epidemiology @ Amsterdam UMC. Exploring the biological underpinnings of Depression & Anxiety and how to improve their treatment.
Delighted to share my second collaboration with @thementalelf.bsky.social
In this piece, I discuss the study "An encompassing Mendelian randomization study of the causes and consequences of major depressive disorder" by @joellepasman.bsky.social et al.
It is known that #depression is linked to increased incidence of metabolic diseases; now, scientists led by @ymilaneschi.bsky.social from 🇳🇱 @amsterdamumc.bsky.social discovered that different types of depression are linked to different cardiometabolic diseases.
And now, a more comprehensive #openaccess edited volume 📚 on #Metabolic #Neuropsychiatry is available, capturing the collective work and reflections from the Ernst Strüngmann Forum.
link.springer.com/book/10.1007...
PNIRS 2026
📣 #PNIRS2026: Save the Date‼️
🗓️ June 22–25, 2026
📍 New Orleans, Louisiana 🇺🇸
✨ Whether your PsychoNeuroImmunology research emphasizes the P, N, or I — we look forward to seeing your work and connecting in The Big Easy!
📻 Stay tuned for more info re: call for abstracts. Please spread the word 🙏🏼
Our study in @JAMAPsych ja.ma/4lVx1eu Using 🧬 we found that disruptions in #energy pathways link to specific #MDD symptoms (⬆️ appetite & sleep). This suggests a #depression profile linked to #metabolic risk, opening doors to targeted treatments. #metabolicpsychiatry
🚨 Preprint Alert 🚨
"Major depression and atherosclerotic disease: linking shared genetics to pathways in blood, brain, heart, and atherosclerotic plaques. " 🧠🫀🩸 The title says it all. Great collaboration with @swvanderlaan.bsky.social . 📄 Read it here: bit.ly/4eTM8T2
In May 2024, I joined an inspiring week at the Ernst Strüngmann Forum on #Metabolic #Neuropsychiatry.
Our first outcome is now in Nature Mental Health:
🧠 A Perspective on energy metabolism in psychiatric disorders
🔗 www.nature.com/articles/s44...
More to come in an upcoming volume—stay tuned!
Nice reminder of our #PNIRS2025 symposium. @eimearfoley.bsky.social, Naoise Mac Giollabhui, @dpmoriarity.bsky.social (in cross-Atlantic telepathic connection) and I will wait for you tomorrow morning!
Looking forward to this!
If you're attending #PNIRS2025 be sure to come to our session (Symposia 4) on Wednesday morning and say hello 👋
@ymilaneschi.bsky.social @dpmoriarity.bsky.social @uob-ieu.bsky.social
Looking forward to connecting with colleagues at #PNIRS2025 in Bordeaux 🇫🇷.
Don't miss our symposium "Dissecting Depression Heterogeneity along Immuno-Metabolic Pathways: Triangulating Evidence from Hierarchical-Phenotyping, Experimental and Genomic Methods"
Time & Outline of the symposium ⬇️
Great discussion. Already on the lookout for the best opportunity to cite Neher 1967!
Our new study in Translational Psychiatry showed that acylcarnitines (involved in mitochondrial #energy production) were linked to the presence+severity of #depression. Bioenergetic pathways may open new avenues in psychiatry #MetabolicPsychiatry check the paper ➡️: rdcu.be/eaWoN
🔬 What is Immuno-metabolic Depression?
"Recognizing immune-metabolic mechanisms could be a relevant treatment target for part of the depressed population opens the doors to personalised psychiatry.”
Read more: 🔗 https://buff.ly/3WRwYpK
#MentalHealthResearch #DepressionResearch
Countdown on for the annual @pnirs.bsky.social meeting in Bordeaux #PNIRS2025 . Very excited for our member sponsored symposium (June 11) with @eimearfoley.bsky.social and @dpmoriarity.bsky.social on #depression heterogeneity and #immunometabolic mechanisms See you in 🇫🇷
Looking forward! We will try to keep you awake
New collaboration published in @brainbehavimm.bsky.social Analyses leveraging #genetic data highlighted the potential role of #metabolic alterations (e.g., dyslipidemia, dysglycemia) as mechanisms connecting #childhood maltreatment with psychiatric + somatic #multimorbidity. doi.org/10.1016/j.bb...
what a masterpiece!
Titolo fantastico
Article screenshot of a genome-wide association study of major depression published in the journal Cell
1/n Our multi-ancestry #GWAS meta-analysis of major depression is now published in @cellpress.bsky.social.
www.cell.com/cell/fulltex...
A thread 🧵:
"Immuno-metabolic #depression: from concept to implementation". Our new collaborative review is out in THE LANCET Regional Health - Europe. We reflected on the current standing of the immuno-metabolic depression concept and its potential value for clinical implementation bit.ly/4iAlVdL #openaccess
Thanks, this gives me the opportunity to acknowledge the amazing editorial work of @eimearfoley.bsky.social, thank you!
It was a pleasure to contribute to @thementalelf.bsky.social. In my piece, I discuss findings from a recent study by Spiller et al. (JAMA Psychiatry) on the heterogeneity of symptom presentation in mental disorder diagnoses.