Rebecca Oramas, PhD

The people behind the papers – Rebecca Oramas and Jianjun Sun ABSTRACT. Drosophila insulin-like peptide 8 (ILP8) is expressed in mature follicle cells, but not in younger follicles. In their work, Jianjun Sun and colleagues show that ILP8 is required to induce o...

If you want to learn more about the story behind the paper check out our Interview published in Development :) doi.org/10.1242/dev....

Most ovulation #research focuses on uncovering the mating-induced #ovulation process. We found that the Drosophila insulin-like peptide #ILP8 is required to induce ovulation and egg laying in UNMATED females as a mechanism to prevent excessive accumulation of mature follicles and oocyte aging

ILP8 serves as a mature follicle sensor to prevent excessive accumulation of mature follicles in Drosophila ovaries and oocyte aging Highlighted Article: ILP8 functions as a mature follicle sensor in virgin females to induce ovulation, prevent excessive accumulation of mature follicles and maintain oocyte quality, likely by binding...

Very excited to see this work from my PhD with Dr. Jianjun Sun, Katarina Yacuk, Dr. Stella Cho, and Natalie Aloisio published!
doi.org/10.1242/dev....

Excited to share our new #biorxivpreprint:
“Sexual dimorphism in the complete connectome of the Drosophila male central nervous system” www.biorxiv.org/content/10.1...

We describe the #connectomics reconstruction and analysis of an entire adult #maleCNS #drosophila central nervous system. 1/10

Our work was also highlighted in Articles of Public Interest by @acerjournal.bsky.social in the feature below!

Both inhibitors effectively blocked the rewarding memories of alcohol, and dibenzazepine reduced alcohol consumption preference, suggesting the Notch pathway might be a good molecular target for more effective AUD treatments.

Alcohol activates #NotchSignaling in memory circuits, so to test whether pharmacologically inhibiting Notch signaling affects ethanol preference, we used γ-secretase inhibitors #dibenzazepine and #compoundE.

We show that FDA-approved #AlcoholUseDisorder (AUD) treatments #naltrexone and #acamprosate reduce ethanol consumption preference and memories for the rewarding effects of alcohol, underscoring the efficacy of drugs in treating AUD.

Our efficient pipeline is great for in vivo screening for novel pharmacotherapies and investigating the molecular mechanisms through which drug therapies impact alcohol preference #AddictionResearch #Pharmacology #Neuroscience

Investigating pharmacotherapies for alcohol use disorder using Drosophila melanogaster This study validates Drosophila melanogaster as a powerful model for alcohol use disorder (AUD) drug discovery. A pipeline to test drug effects on acute alcohol response, alcohol consumption, and mem...

Ever wonder how fruit flies can be used to help uncover novel therapies for #AlcoholUseDisorder? My new paper with @karlakaun.bsky.social describes a behavioral assay pipeline using #Drosophila that can be used to screen new treatments and to investigate the mechanism of currently available drugs.

Our work was also highlighted in the Articles of Public Interest by @acerjournal.bsky.social in the feature linked below :)

Alcohol activates #NotchSignaling in memory circuits, so to test whether pharmacologically inhibiting Notch signaling affects ethanol preference, we used γ-secretase inhibitors #dibenzazepine and #compoundE.

We show that FDA-approved #AlcoholUseDisorder (AUD) treatments #naltrexone and #acamprosate reduce ethanol consumption preference and memories for the rewarding effects of alcohol, underscoring the efficacy of drugs in treating AUD.

Our efficient pipeline is great for in vivo screening for novel pharmacotherapies and investigating the molecular mechanisms through which drug therapies impact alcohol preference #AddictionResearch #Pharmacology #Neuroscience

My linocut portrait of Isabella Aiona Abbott in indigo on cream coloured paper. She’s facing forward at a table in a shirt and sweater vest with a sheet with algae samples on the table. In my print, she is surrounded by algae of the Pacific, all of which appeared in Abbott's research publications, including several species she discovered, or based on images of specimen she personally collected or whose traditional use as food she documented. The algae are in pinks, khaki green and rust.

Day 26 #SciArtSeptember prompt forage. My #linocut of #botanist Isabella Aiona Abbott (1919-2010), 🧪🐡👩🏻‍🔬 #histsci renown algae expert, celebrated seaweed cook, devoted teacher & mentor, expert on Hawaiian ethnobotany, the first Indigenous Hawaiian woman to earn a doctorate in science & the first woman

Happy Birthday, Rosalind Franklin. She captured an X-ray diffraction image of DNA and stated that a helical structure was probable. Watson and Crick then created a detailed model based on her results. They initially received credit for the discovery and were awarded the Nobel Prize after her death.🧪

(no title) droso4public is a central resource store supporting science communication and advocacy for Drosophila

Dear GenZ members of the #Drosophila community! You are needed to make cool fly research viral in your social media world! As a boomer I do not understand that sphere, but I can consult and contribute our enormous fund of outreach resources: droso4public.wordpress.com. Please, get in contact!

And that's a wrap! I had a ton of fun at the inaugural New England Addiction Neuroscience Research Conference Friday and am looking forward to seeing everyone next year, if not sooner! newenglandaddictionconsortium.wordpress.com/annual-confe...

So grateful to have been a part of organizing the first New England Addiction Neuroscience Research Conference alongside @karlakaun.bsky.social, @dgordonwinder.bsky.social , @mariedoyle.bsky.social, & John Hernandez. I learned so much from the wonderful talks and the discussions they sparked!

Harvard University lays off fly database team The layoffs jeopardize this resource, which has served more than 4,000 labs for about three decades.

FlyBase, a Drosophila database, will lose a third of its team in early October because the Harvard grant that covered the employees’ salaries was canceled. Scientists warn that losing FlyBase could devastate fly research.

By @claudia-lopez.bsky.social

www.thetransmitter.org/community/ha...

Data tells a story, and I can help you illustrate it 🎨📈

I specialize in creating clear, accurate, and visually compelling figures for your research, from manuscripts to grant applications.

Check out my website! www.oramasdataviz.com

#SciComm #DataViz #Science #SciArt #Research

Did you know #fruitflies ovulate roughly 70 times a day? This makes #Drosophila a powerful model for studying the #genetics behind #ovulation in humans.

Here's a stunning look at fly ovaries under a #fluorescent microscope. Each blue dot is a cell nucleus. The beauty of #DrosophilaOogenesis!

My interpretation of #HeLa cells: 1st collected from a 31y/o #africanamerican woman, #HenriettaLacks, who was suffering from #cervicalcancer. These #cells are immortal and highly proliferative, making them a great cell line for #research. Learn more here! youtube.com/watch?v=22lG...

Coming up in just a few weeks! @karlakaun.bsky.social and colleagues have great things in store. Prizes available for trainee presentations. Spots are still available, so please consider attending! Looking forward to chatting about growing and connecting addiction neuroscience in the area.

Omar Abubaker, Eric Nestler and I spoke about how science brings hope for those suffering from alcohol and substance use disorders at an Advocacy forum @sfn.org #SfN24. Our message is that as scientists we need to be better at communicating this. @ericjnestler.bsky.social