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Center for Immunology-UMN

@cfi-umn

The Center for Immunology at the University of Minnesota Medical School is driven to make discoveries about the immune system that improve human health and well-being. Website: immunology.umn.edu LinkedIn: www.linkedin.com/in/immunology/ X: x.com/CFI_UMN

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02.04.2025
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Latest posts by Center for Immunology-UMN @cfi-umn

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IL-4–STAT6 signaling delays protective CD8+ T cell bystander activation by antagonizing IL-18 sensing - Nature Immunology Maurice et al. examine how cytokines regulate antigen-independent activation of memory CD8+ T cells. They show that IL-4 signaling changes the quality of the bystander T cell response by antagonizing ...

Exciting new work from the Jameson and Hamilton Hart labs! Published in Nature Immunology, this study shows IL-4–STAT6 delays CD8+ T cell bystander activation by modulating IL-18 sensing, a key insight into memory T cell responses.
Read more: www.nature.com/articles/s41...

10.02.2026 21:52 👍 2 🔁 1 💬 0 📌 0
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🎉Congratulations to Dr. Courtney Matson, Masopust Lab, on being named a finalist for the 2026 NPA Postdoc of the Year! Her science and her leadership for UMN postdocs make this recognition so well‑deserved.👏👏

10.02.2026 21:33 👍 1 🔁 0 💬 0 📌 0
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We kicked off 2026 with our first #CeMMinar featuring David Masopust (UMN Medical School), who shared insights on CD8 #TCells surveillance, migration & memory. Thanks to David & our hosts CeMM PI Clarissa Campbell & Adjunct PI @andreasbergthaler.bsky.social! 👏
#Immunology

29.01.2026 15:19 👍 5 🔁 2 💬 0 📌 0
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Congratulations to Sean Tracy for being selected by @ASH_hematology to receive the ASH Scholar Award! www.hematology.org/newsroom/pre...
#ASHAwards #Fight4Hematology

23.01.2026 17:36 👍 1 🔁 1 💬 0 📌 0
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the word congratulations is surrounded by purple confetti ALT: the word congratulations is surrounded by purple confetti

Congratulations Dr. Erandika Senevirathne on your successful thesis defense!! 🎉🎓

16.01.2026 16:38 👍 0 🔁 0 💬 0 📌 0
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Join us Friday, Jan. 16, 2026, for Erandika Senevirathne's Final Ph.D. Defense: "Steady-state phosphorylation of SHIP1 by Lyn restricts macrophage activation in the absence of a phagocytic synapse."
Advisor: Tanya Freedman(@tfreedmanlab.bsky.social),
9:00 am, 1-125 CCRB

15.01.2026 14:27 👍 2 🔁 1 💬 0 📌 0
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Save the Date!
Join us for the 63rd Annual Blumenthal Lecture on February 27th, featuring Dr. E. John Wherry as our invited speaker.
🔗 Details: z.umn.edu/Blumenthal
🗓️Add to calendar: z.umn.edu/Blumenthal2026

09.01.2026 15:32 👍 2 🔁 0 💬 0 📌 0
Diagram showing immune cell interactions in thymus regions with labeled microenvironments and IFN concentration gradients.

Diagram showing immune cell interactions in thymus regions with labeled microenvironments and IFN concentration gradients.

#ICYMI: From Dr. Kristin Hogquist at the Center for Immunology-UMN focuses on interferon (IFN) production within the thymus and its effects on thymic APCs and developing thymocyte while also examining the importance of T-cell tolerance to IFN. The Journal of Immunology: https://ow.ly/UEMw50VEIEx

29.12.2025 20:00 👍 5 🔁 3 💬 0 📌 0
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Warmest wishes for a holiday season full of joy and cherished moments from our Center for Immunology community. We are grateful for the dedication and collaboration of our faculty, trainees, staff, and partners, and we look forward to continued discovery and shared progress in the year ahead.

24.12.2025 15:57 👍 0 🔁 0 💬 0 📌 0
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Congratulations to CFI Associate Director Dr. David Masopust, recipient of the 2026
@aai.org Meritorious Career Award! This award recognizes his exceptional achievements and enduring impact in the field of immunology research.

19.12.2025 20:09 👍 1 🔁 0 💬 0 📌 0
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One message from our #WorldScienceDay Q&A continues to resonate.
“#Immunology intersects with many, many disciplines.”
— IUIS Vice President Carla Rothlin

Revisit the full conversation on #Immunohub: https://loom.ly/UaZHw7g

#ImmunologyWithoutBorders

18.12.2025 04:01 👍 2 🔁 1 💬 0 📌 0
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Congratulations to our Director, Dr. Carla Rothlin, on being selected as the 2026 recipient of the @aai.org Lancefield Mid-Career Achievement Award. This well-deserved honor recognizes her outstanding contributions to immunology and leadership in the field.

19.12.2025 00:08 👍 2 🔁 1 💬 1 📌 0
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Functional genomics for improving adoptive T-cell transfer therapies Adoptive cell therapy (ACT) has shown remarkable success in the treatment of some malignancies, particularly leukemia. However, there are multiple factors that limit the durability of ACT in solid tum...

New from CFI’s Stromnes, Tsai, Moriarity and colleagues: a great overview of how forward genetic screens, including CRISPR & Sleeping Beauty, can uncover new engineering strategies to strengthen adoptive T-cell therapy for solid tumors. jitc.bmj.com/content/13/1...

10.12.2025 23:57 👍 2 🔁 0 💬 0 📌 0
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Congratulations to Bryce Binstadt, MD, PhD, who began his two-year term as President of the Rheumatology Research Foundation in October 2025. The Foundation supports research and training to improve the health of patients with rheumatic diseases. Learn more: www.rheumresearch.org/leadership

05.12.2025 22:17 👍 0 🔁 0 💬 0 📌 0

Congratulations to the Geoff Hart Lab, including @Jenna_K_Dick, A. Sangala, and collaborators! Their MIS C NK cell and monocyte dysfunction paper was named a top article in pediatric asthma, allergy, and immunology by the AAP.
Read more: publications.aap.org/pediatrics/a...

05.12.2025 20:26 👍 0 🔁 0 💬 0 📌 0
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Don't miss CFI’s David Masopust, Carmen Gerlach, and Ravi Ahmed for a special webinar hosted by Nature Reviews Immunology, with support from Stemcell Technologies on the new "T cell nomenclature guidelines"!
Happening Dec 8 at 11 am CT.
Register here: z.umn.edu/Tcellnomencl...

05.12.2025 20:14 👍 1 🔁 0 💬 0 📌 0
https://z.umn.edu/CFINewsletter

https://z.umn.edu/CFINewsletter

Our 2025 CFI Newsletter is now live on our website, z.umn.edu/CFINewsletter! Catch up on this year’s research highlights, awards, trainee achievements, and more.
Want to join our email list? Send a request to cfi@umn.edu.

02.12.2025 15:30 👍 0 🔁 0 💬 0 📌 0
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Clarivate Highly Cited Researchers 2025 The Highly Cited Researchers 2025 list identifies and celebrates individuals who have demonstrated significant and broad influence in their fields of research. Through rigorous selection criteria and ...

Proud of UMN/CFI faculty David Masopust, Dan Knights, and Bruce Blazar, named to the 2025 Highly Cited Researchers list! Their groundbreaking work in T cell biology, microbiome research, and immunotherapy drives global advances in immunology. z.umn.edu/CFIhighlycited

30.11.2025 19:47 👍 3 🔁 0 💬 0 📌 0
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a greeting card that says happy thanksgiving ALT: a greeting card that says happy thanksgiving

This Thanksgiving, the CFI community extends our heartfelt gratitude to our trainees, faculty, staff, collaborators, and alumni.
Your dedication drives discovery, strengthens our mission, and advances the future of immunology.
We are thankful for all you do.
Wishing you a restful and joyful holiday.

27.11.2025 17:05 👍 1 🔁 0 💬 0 📌 0
A special collection on targeting the immune system—Editorial We have recently witnessed a revolution in our ability to modulate the immune system to increase the recognition and destruction of infectious agents and cancer cells, as well as to selectively dampen...

In their new editorial, Carla Rothlin and J. S. Gutkind present a Special Collection on Targeting the Immune System, covering advances in cancer immunology, chronic inflammation, neuroimmune biology, addiction immunotherapy, and regenerative immunity.
jpet.aspetjournals.org/article/S002...

27.11.2025 02:23 👍 0 🔁 0 💬 0 📌 0
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Guidelines for T cell nomenclature - Nature Reviews Immunology This Consensus Statement clarifies the existing subset-based nomenclature for T cells. Furthermore, it proposes an alternative modular nomenclature that is designed to be brief and flexible and to avo...

New from Masopust, Ahmed, and colleagues!
A major multi-lab Consensus Statement offering updated, field-wide guidelines for defining and reporting T cell populations, bringing clarity, consistency, and transparency to T cell research.
nature.com/articles/s41...

21.11.2025 18:28 👍 0 🔁 0 💬 0 📌 0
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IL-15 complex enhances therapeutic efficacy of anti-PD-L1 in a T cell–dependent and NK cell–independent manner in a murine model of pancreatic ductal adenocarcinoma Abstract. Pancreatic ductal adenocarcinoma (PDA) is a lethal malignancy resistant to therapy including immune checkpoint blockade (ICB). We previously show

Congrats to the Stromnes Lab: Adam Burrack, Alex Tsai, Madeline Ellefson, Zoe Schmiechen, Brandon Larsen, Kristina Burrack, and Ingunn Stromnes on their new paper showing IL15 complex enhances anti–PDL1 therapy in PDA via sustained T cell function.
pubmed.ncbi.nlm.nih.gov/41254224/

21.11.2025 18:01 👍 0 🔁 0 💬 0 📌 0

Congratulations to the Freedman Lab and MD/PhD student Anders Lindstedt on this exciting new JLB paper! A fantastic team effort with the Williams Lab-well done! 👏🧪

18.11.2025 16:25 👍 3 🔁 0 💬 0 📌 0

Congratulations to T. Dileepan on the publication of his collaborative work with Jennifer Gommerman’s group in Cell, uncovering how TFH1 cells and B-cell MHC class II signaling drive protective IgA responses during mucosal viral infection: www.cell.com/cell/abstrac...

18.11.2025 16:10 👍 3 🔁 1 💬 0 📌 0
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Yesterday was #WorldScienceDay — but honestly, every day is science day here at CFI. 🧬💙
We’re proud to be part of a global community that builds trust, shares knowledge, and pushes discovery forward.

11.11.2025 13:36 👍 0 🔁 0 💬 0 📌 0
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Vobořil, Hogquist @cfi-umn.bsky.social and colleagues reveal the #thymus as a niche for diverse, developmentally distinct #myeloid cells and elucidate their specific requirements for development and maturation. rupress.org/jem/article/...

#Hematopoiesis #Tolerance #LymphocyteBiology

05.11.2025 20:30 👍 3 🔁 1 💬 0 📌 0

Science builds trust and shapes tomorrow. On #WorldScienceDay, Dr. Carla Rothlin, IUIS Vice-President and CFI Director, joins global voices for the IUIS Roundtable — “Trust, Transformation, and Tomorrow.”
🌍 Nov 10 | 9:00 am (CST)
Register here: immunohub.iuis.org/b2726748afc1...

04.11.2025 17:49 👍 1 🔁 0 💬 0 📌 0
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Carla Rothlin Elected IUIS Vice-President - AAI News AAI Member Carla Rothlin was recently elected vice-president of the International Union of Immunological Societies

AAI member Carla Rothlin, PhD, was elected vice-president of @iuis-online.bsky.social at the 2025 IUIS Congress. While moving her lab to the University of Minnesota to direct the Center for Immunology, Dr. Rothlin generously took the time to answer some questions for us: ow.ly/PG7N50WWL4Q. #AAInews

15.09.2025 18:05 👍 6 🔁 2 💬 0 📌 0
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Join us Friday, Oct 17th, 2025 for Anders Linstedt's MICaB Final Ph.D. Defense: "Lyn kinase controls Toll-like receptor signaling in a cell-specific, isoform-independent manner" Advisor: Tanya Freedman(@tfreedmanlab.bsky.social), 9:00 am, 1-110 LRB/MTRF or Zoom info at immunology.umn.edu

14.10.2025 17:23 👍 3 🔁 1 💬 0 📌 0

Dr. Marc Jenkins is stepping back from leadership at CFI, but he is not retiring from lab work. His research and mentorship will continue to inspire. 🙌🔬

25.08.2025 15:18 👍 1 🔁 0 💬 0 📌 0