Microglia, previously thought to protect against amyloid plaques in Alzheimer's disease, have been shown to actively promote plaque formation, prompting a reevaluation of therapeutic strategies. doi.org/hbrzgz
Allostasis first!
What if the brainβs core function was neither to think, nor to feel, nor even to sense, but rather to perform allostasis?
www.cell.com/neuron/fullt...
Ropinirole hydrochloride mitigates oxidative stress and neuroinflammation via the PI3K-mTOR pathway in TDP-43 hiPSC-derived microglial-like cells #NeuroDegeneration π§ͺπ§
https://www.biorxiv.org/content/10.64898/2026.03.07.710283v1
A person must hold on to hope. A person must never abandon the defense of human dignity not even for the sake of people they have never known and never will. Because dignity is not merely something we possess it is a trust we are obliged to carry.
Ants extinguish fires. Birds defeat elephants.But even if you do not win, even if the tide never turns the world will not have turned you. The world will not have darkened your heart. And that is something more enduring than any victory
But the ababil birds came small, winged, seemingly powerless and they defeated the elephants. One of history's mightiest armies was stopped by birds carrying stones.And perhaps one day, everything changes again just like this. Small, powerless, invisible beings alter the course of history.
But you will try. Because trying is itself an answer the most human answer to silence, indifference, and despair.
These stories exist in every culture, in every corner of the world.When Abraha's army of elephants marched toward the Kaaba, no one believed anything could stop them.
living is the most beautiful, the most real thing.''
You will bury your life in a laboratory, a cause, a struggle so that people whose names you do not know, whose voices you have never heard, whose language you do not speak, may live longer and suffer less.Perhaps you will not win.
that, for example, your hands tied behind your back, your back against the wall,/ or in a laboratory, with your thick-rimmed glasses and white coat,/ you can die for people,
even for people whose faces you have never seen/ even though no one has forced you to do so/ even though you know that
they cannot extinguish the fire of course they know. But they want to make their stance known. They want their own essence to remain unchanged. And so they carry water. A turkish poet nazΔ±m hikmet once wrote:
''You must take living seriously,/ so seriously, to such a degree
Ibrahim is sentenced to be thrown into fire by Nemrud for destroying the idols.A massive, scorching, unstoppable fire. Everyone either joins in this collective evil or falls silent. But the ants do not fall silent. With their tiny bodies, they carry water toward the towering flames.They know
the tide of history is more often than not futile. But you stand anyway. You stand so as not to forget who you are. Because some battles are not fought to be won they are fought so as not to betray yourself.There is an ancient story told in the Islamic tradition.
Sometimes, a Person Must Fight a Battle They Know They Will Lose.
A person sometimes enters battles they know they will lose and they must. Because dignity demands it. You cannot end wars, you cannot end hunger, you cannot end oppression. As an individual, standing against
A uniquely hopeful project: a mental health program for children who suffered detention in occupation prisons.
Not sentences we should write. But we can help. Support goes towards materials and facilitation for workshops & more:
π±Changes in fear-avoidance, depression, and anxiety mediate pain recovery after fully-remote digital rehabilitation for chronic spinal pain.
Findings underscore the importance of addressing psychological factors in digital care.
academic.oup.com/ptj/advance-...
Restaurants, billboards, commercialsβ¦ what brain circuits link context to appetite? π§ ππ½οΈ
Very happy to finally share a major update in our work exploring the hippocampus and lateral septum in calibrating food consumption! π©
Major thanks to our lab and collaborators! βοΈβοΈ
www.cell.com/neuron/fullt...
A great poet once said, βIt ainβt where youβre from, itβs where youβre at.β For developing brain cells, itβs both! Published in @cp-neuron.bsky.social, Stan Kerstjens & @tonyzador.bsky.social put forward a new theory for how the brain organizes itself during development. www.cshl.edu/a-new-theory...
The U.S. government has lost more than 10,000 STEM Ph.D.s since Trump took office.
A Science analysis reveals how many were fired, retired, or quit across 14 agencies. Read more: https://scim.ag/4boPkq8
@standupforscience.bsky.social Founder @cdelawalla.bsky.social shares what psychologists can uniquely offer to support #science in the U.S. political sphere.
#PsychSciSky
March 8th feminist night march from Turkey.
1-If you despair, remember this crowd.
2-Keep your anger alive, hold your head high, and hold your sister's hand tightly.
4-There's fragile masculinity at dinner today.
I want to write a fun little post on what we've learned in neuroscience in the last 20 years. What are the most interesting results you can think of? Biggest trends?
In honor of #WomensHistoryMonth, celebrate the many contributions women have made to the field of neuroscience. vist.ly/4u9sh
Efficacy of BodyMirror Clinical MS Multimodal Game-Based Digital Therapeutic for Remote Monitoring and Neurorehabilitation in Multiple Sclerosis: Protocol for a Multisite Randomised Controlled Trial #NeuroDegeneration π§ͺπ§
https://www.medrxiv.org/content/10.64898/2026.03.06.26347719v1
New paper from the lab is out in Cell Reports:
www.sciencedirect.com/science/arti...
Brain Growth Patterns Predict 2-Year Neurodevelopment bioengineer.org/brain-growth...
Growth of fetal brain with long-term neurodevelopmental validation provides insights into in utero brain maturation and their predictive relationship with postnatal neurological function. doi.org/10.1038/s414...
Mitochondria contact lipid droplets through the mitochondrial import complex binding to lipid metabolism enzyme Ayr1
πhttps://rdcu.be/e7dRa
bit.ly/4baJZAO
ERβmitochondria calcium coupling is essential for glucose-induced GLP-1 secretion in L cells @diabetologiajnl.bsky.social
link.springer.com/article/10.1...
βXia, Zhang, Peng, Chen et al. find that #Leydig cells and macrophages show bidirectional mitochondrial transfer through #ExtracellularVesicles, ensuring Leydig cells have functional #mitochondria. The exchange is needed for testosterone production.
bit.ly/40US4Vy
Anarcha Westcott mother of gynecology 17 yr old enslaved underwent 30 operations without anesthesia for a vesicovaginal fistula James Marion Sim was the racist man who performed these surgeries on her and is denoted as the father of Gynecology. strength, grit, and bravery survived those procedures.
who cannot afford to dissent, who cannot afford to be seen their silence is political too. To pretend otherwise is not neutrality. It is complicity. I will not perform apolitical comfort for anyone's peace of mind. My existence, like yours, is already a political act. I'd rather be honest about it.
