Franklin_LAB

Happy to share (and proud to have contributed) to this new PDAC paper on ASC/PYCARD: cancer-cell ASC links innate immunity to mitochondrial metabolism—and extracellular ASC speck targeting with nanobodies suppresses tumorigenesis in vivo. 🤩
www.nature.com/articles/s41...

😜

www.frontiersin.org/journals/pha...

A few cells make the difference in monocyte interleukin release - Nature Immunology Single-cell analysis shows that the release of interleukin-1β in human monocytes arises from a small subset of pyroptotic cells, rather than from non-canonical secretion pathways.

I kind of suspected this non-lytical IL-1b secretion by viable cells was BS...
www.nature.com/articles/s41...

"...So, the long-suspected ‘non-canonical’ secretion pathways, invoking unconventional secretion routes, atypical inflammasome regulation, are probably a misinterpretation artefact..."

Thank you to our editor, Kirsty Minton, and the staff at NRI for the opportunity to share our thoughts on this emerging topic.

NLRP3 is a thermosensor that is negatively regulated by high temperature Inflammation is an essential response to infection and injury, but unregulated inflammation is damaging and must be limited by negative feedback signalling. Inflammasome signalling drives local inflam...

Check out this new thermo-hot paper from the @colllab.bsky.social Lab. Glad to contribute and work with her team.

www.biorxiv.org/content/10.1...

High-speed mapping of whole-mouse peripheral nerves at subcellular resolution In contrast to the rapid advancements in mesoscale connectomic mapping of the mammalian brain, similar mapping of the peripheral nervous system has re…

www.sciencedirect.com/science/arti...

📌 Testimonials (anonymously or not) reporting abusive behavior.
📌 Evidence where possible.

⚠️ This is NOT a tool for personal vendettas or individual grievances.
⚠️ Only cases with substantial reports, patterns of abuse, and corroborated evidence will be listed.

These toxic environments ruin careers, push talented scientists out of academia, and foster a culture of fear.
Introducing the "Bully Blacklist" Exposing Academic Abuse with Evidence.
A community-driven initiative to expose academic bullies based on cumulative evidence and multiple testimonials.

Uncovered: Abuse at top German science institution – DW – 03/13/2025 The Max Planck Society is Germany's preeminent research organization, boasting 31 Nobel laureates. But insufficient oversight leaves international scientists exposed to abuse and the whims of the inst...

The recent DW article sheds light on a harsh truth: academic bullying, harassment, and abuse are widespread, yet the perpetrators remain in power, protected by institutions that refuse to hold them accountable.

Cell-autonomous innate immunity by proteasome-derived defence peptides - Nature Proteasomal degradation of cellular proteins generate defence peptides constitutively and in response to bacterial infection. Such peptides might provide a source of natural antibiotics that...

www.nature.com/articles/s41...

Too much Partying.. Now, back to work! 🙃

Musk to Unions: The Nazis Are Coming How Elon Musk’s DOGE logo is not a dogwhistle, it’s a slap in the face

I couldn't sleep that well last night with my worries about the Nazis taking over our govt. And the media refuses to report on it honestly. WTF!
www.mind-war.com/p/musk-to-un...

Hurry up, as we have limited spots.

We look forward to hosting you in Vienna. 😃

DEADLINE for application: March 1

Please apply directly to Tim Sparwasser Tim Sparwasser (sparwasser.office'at'uni-mainz.de) or Bernardo Franklin (franklin'at'uni-bonn.de) with the title of the lecture and a half-page abstract.

We are happy to announce the second edition of the Joint Symposium of the Brazilian (SBI) and German (DGfI) Societies for Immunology.

The event will happen in Vienna, Austria August 15-16, 2025, and will bring together Brazilian and German immunologists.

2nd Brazilian-German Immunology Workshop
Vienna, Austria
August 15-16, 2025
DEADLINE for application: March 1
Pls apply to Tim Sparwasser (sparwasser.office’at’uni-mainz.de) or Bernardo Franklin (franklin’at’uni-bonn.de) by March 1 2025, stating the title of the lecture and a half-page abstract.

IL-1β enhances susceptibility to atrial fibrillation in mice by acting through resident macrophages and promoting caspase-1 expression - Nature Cardiovascular Research Moreno-Loaiza et al. found that interleukin-1β, acting upon cardiac resident macrophages, promotes atrial fibrillation in mice, and this mechanism may represent a common pathway connecting various ris...

#WeekendRead. #EveryOrganIsAnImmuneOrgan. Medei &co show @naturecvr.bsky.social that IL1b initiates a positive feedback loop leading to IL1b production by, & response of, cardiac resident macrophages which drives atrial fibrillation. Targeting resident macrophages is protective.
#ScienceSavesLives

Please, can you add me? Thank you.

Cytokine-armed pyroptosis induces antitumor immunity against diverse types of tumors - Nature Communications ‘Gasdermin-mediated pyroptosis can induce anti-tumor immune responses. Here the authors report a toolbox of gasdermin D variants for induction of pyroptosis, showing that, when combined with intratumo...

As my inaugural post on BlueSky, I’m happy to share the first cancer-related study from Pyrocellfluencers spearheaded by Sara Orehek.
www.nature.com/articles/s41...

Tissue-resident memory CD8 T cell diversity is spatiotemporally imprinted - Nature Profiling of the location and transcriptome of tissue-resident memory CD8 T cell formation at single-transcript resolution finds regionalized signalling as the basis of immune diversity in t...

It turns out the immune system is playing 4D chess while we thought it was just playing checkers. Using #spatialtranscriptomics from @10xgenomics.bsky.social and @vizgen.bsky.social we were able to peek into the secret lives of tissue resident T cells in the gut as they form after infection 1/n

Platelet partnerships and lasting memories - Nature Immunology Pulendran and colleagues define a molecular signature that can be used to predict the durability of antibody responses to vaccination and reveal important insights into the mechanisms by which vaccine...

Aren't platelets just fantastic?
www.nature.com/articles/s41...

Loved this infographics

Why are we seeing more pandemics? Our impact on the planet has a lot to do with it When human activities disrupt and unbalance ecosystems, such as by way of climate change and biodiversity loss, things go wrong.

theconversation.com/why-are-we-s...

But of course, the best part of it, is to provide students and young scientist with the opportunity to extend their horizons and foster collaborations with the brilliant scientists at the CRID/FMRP. Looking forward to two years of exciting exchanges.

This partnership will foster international collaboration and research on inflammatory diseases, and strengthen ties between Germany and Brazil. 🇩🇪🤝🇧🇷
@daadworldwide.bsky.social e.bsky.social @agenciafapesp.bsky.social y.social @immunosens.bsky.social

Great news! Our exchange program with the Medical Faculty of Ribeirão Preto (USP) will be funded by the DAAD & FAPESP, through the PPP program www.daad.de/de/infos-ser....

The skin’s ‘surprise’ power: it has its very own immune system The finding could lead to the development of needle-free vaccines.

Now, Check this out!!! The skin has its own immune system!
The skin isn’t just a barrier—it’s an active player in immunity, with its very own immune system. 🌟 A surprising discovery that could reshape how we treat infections, allergies, & autoimmune diseases.
www.nature.com/articles/d41...

Way too many… and it also depends if you’re asking about bacteria, plants, or mammals defense systems. Still there are many in all these species..
From CRISPR, oxidative burst, pore forming toxins, nucleases and proteases, mechs of nutrient and iron deprivation, to phagocytosis and antibodies,…

Great time today hosting Jose Carlos Alves Filho from the @USP Ribeirao Preto (FMRP), with us for a nice salad&talk.