Virtual ChemBioTalks

I am very happy that we again managed to invite two world-leading scientists as keynotes for the 6th Virtual @chembiotalks.bsky.social.

We are working on an exciting additional program. Stay tuned!

Mailing list: fd24.formdesk.com/universiteit...

#ChemSky #ChemBio #ChemBioTalks

We are very excited that Michelle Chang (@mchanggroup.bsky.social) and Giulio Superti-Furga (@supertifurgalab.bsky.social) will be our keynote speakers at this year's event on September 29th, 2026.

If you do not want to miss anything, sign up for our mailing list: fd24.formdesk.com/universiteit...

We are looking for your input for exciting speakers to invite for the 6th Virtual @chembiotalks.bsky.social! There are 10 days left to send in your suggestions.

#ChemSky #ChemBio #DrugDiscovery

There are only 10 days left to suggest your favorite speakers for the 6th Virtual ChemBioTalks! Make use of this opportunity to let us know, who you would like as a speaker.

#ChemSky #Chemistry #ChemBio #DrugDiscovery #EverywhereChem

CC: @euromedchem.bsky.social @youngscinet.bsky.social

Amazing news that the 5th Virtual @chembiotalks.bsky.social attracted 450 participants from 50 countries.

If you are as excited as we are, already mark next year's date (29th of September, 2026) in your calendars and make sure to suggest your favorite speakers!

#ChemSky #ChemBio #DrugDiscovery

We are excited that the 5th Virtual #ChemBioTalks attracted 450 participants from 50 different countries world-wide. Thank you all for making this such an engaging event!

If you want to suggest speakers and keynotes for 2026, please do so by October 31st at ChemBioTalks@gmail.com

#ChemBio #ChemSky

Take this chance and suggest your favorite speakers (or those that you always wanted to hear, but did not have a chance yet) for the 6th Virtual @chembiotalks.bsky.social
#ChemBio #ChemSky #DrugDiscovery

We had amazing 5th Virtual #ChemBioTalks. Thank you to all the speakers and organizers for making this possible!

Already mark your calendars for the 6th edition on September 29th, 2026. You are invited to suggest speakers via ChemBioTalks@gmail.com.

#ChemBio #ChemSky #DrugDiscovery

PROTAC targeted protein degraders: the past is prologue - Nature Reviews Drug Discovery Targeted protein degradation with proteolysis-targeting chimeras (PROTACs) has the potential to tackle disease-causing proteins that have historically been highly challenging to target with conventional small molecules. This article summarizes the first two decades of PROTAC discovery and discusses key areas for the future of this therapeutic modality, including establishing the target classes for which it is most suitable and extending its application beyond oncology.

Inspiring talk by @craigmcrews.bsky.social at the 5th Virtual #ChemBioTalks. He talked about the power of inducing protein-protein interactions for #DrugDiscovery and the paradigm-shift from occupancy-driven to event-driven pharmacology that this enables. www.nature.com/articles/s41...

Inspiring keynote lecture by @craigmcrews.bsky.social at the 5th Virtual #ChemBioTalks. He reported on his group's pioneering work on proximity-inducing molecules for applications in #DrugDiscovery.
www.nature.com/articles/s41...
#ChemSky #ChemBio

A modular platform for bioluminescent RNA tracking - Nature Communications Studying RNA dynamics in vivo often relies on fluorogenic approaches, but these can be hampered by factors such as limited sensitivity and sample autofluorescence. Here, the authors describe an ultrasensitive platform for RNA imaging, which features RNA tags that recruit light-emitting luciferase fragments.

Great talk by Jenn Prescher at the Virtual @chembiotalks.bsky.social. She talked about her group's many contributions to expanding the toolbox of bioluminescent tools. Cool insights into tracking RNA. www.nature.com/articles/s41...
#ChemBio #ChemSky

Interesting Flash Talk by Jingzhi Fan at the 5th Virtual @chembiotalks.bsky.social. He talked about the use of metabolomics to better understand bone repair.

Interesting Flash Talk by Veronika Slachtova at the 5th Virtual @chembiotalks.bsky.social. She talked about her exciting research into triazinium probes for wash-free bioimaging.

Exciting Flash Talk by @shubha-pani.bsky.social at the 5th Virtual @chembiotalks.bsky.social. She presented her exciting work on masked acyl chlorides that can be liberated in an orthogonal fashion by an exogenous esterase in human cells for proximity labeling. www.nature.com/articles/s41...

Very interesting talk by Jenn Prescher at the 5th Virtual #ChemBioTalks. She talked about the tools that her group is developing to track RNA using (multiplexed) bioluminescence. www.nature.com/articles/s41...

Going strong on my streaming and social media setup for the 5th Virtual @chembiotalks.bsky.social! Very exciting science.
#ChemSky #ChemBio

We had a great Flash Talk session at the 5th Virtual #ChemBioTalks. We heard about #metabolomics to understand bone repair (Jingzhi Fan), fluorogenic triazinium probes (Veronika Šlachtová) and masked acylation reagents for #ChemBio (@shubha-pani.bsky.social).

The ATM Kinase Inhibitor AZD0156 Is a Potent Inhibitor of Plasmodium Phosphatidylinositol 4‐Kinase (PI4Kβ) and Is an Attractive Candidate for Medicinal Chemistry Optimization Against Malaria AZD0156, an ATM kinase inhibitor in clinical development, shows promising multistage antiplasmodial activity by targeting Plasmodium falciparum phosphatidylinositol 4-kinase (PfPI4Kβ). With an improv...

Very interesting talk by @kellychibale.bsky.social at the 5th Virtual @chembiotalks.bsky.social. Great insights into the highest priorities for new #malaria drugs:
- novel modes-of-action
- reduced risk of resistance
- multi-stage activity
(1/2)
onlinelibrary.wiley.com/doi/10.1002/...

The 5th Virtual #ChemBioTalks continue with an insightful talk by @kellychibale.bsky.social. He talked about his group's research into new treatments for #malaria. Great insights into the repurposing of anti #cancer #kinase inhibitors to treat P. falciparum. onlinelibrary.wiley.com/doi/10.1002/...

The Natural Redox Cofactor Pyrroloquinoline Quinone (PQQ) Enables Photocatalytic Radical Cyclizations Natural alcohol and sugar dehydrogenases that utilize the redox cofactor pyrroloquinoline quinone (PQQ) can be repurposed for enantioselective photoredox catalysis. Upon blue-light irradiation, redox...

Interesting talk by @cathleenzeymer.bsky.social at the 5th Virtual @chembiotalks.bsky.social. Cool insights into designing and evolving artificial photocatalytic enzymes. Interesting example of using pyrroloquinoline quinone (PQQ) as a cofactor. (1/2) onlinelibrary.wiley.com/doi/10.1002/...

Insightful talk by @cathleenzeymer.bsky.social at the 5th Virtual #ChemBioTalks. She talked about the design and evolution of artificial #enzymes for photocatalysis. Interesting insights into both repurposing of existing enzymes and de novo design. onlinelibrary.wiley.com/doi/abs/10.1...

ProtTrans: Toward Understanding the Language of Life Through Self-Supervised Learning Computational biology and bioinformatics provide vast data gold-mines from protein sequences, ideal for Language Models (LMs) taken from Natural Language Processing (NLP). These LMs reach for new pred...

Great talk by @machine.learning.bio at the 5th Virtual @chembiotalks.bsky.social. He talked about the use of #MachineLearning and #BigData to address biological questions. Cool insights into both predicting functions and designing proteins
ieeexplore.ieee.org/document/947...
arxiv.org/abs/2503.00710

Exciting talk by Christian Dallago (@machine.learning.bio) at the 5th Virtual #ChemBioTalks. He talked about the development of #MachineLearning tools to better understand biological systems. Great insights how #BigData from sequencing can be used to predict function. www.cell.com/trends/bioch...

He also highlighted his group's exciting work on expanding the genetic code on the RNA level. www.nature.com/articles/s41...

CRISPR-free, programmable RNA pseudouridylation to suppress premature termination codons Song et al. developed a programmable RNA base editor, termed RESTART, relying on guide snoRNA to mediate site-specific pseudouridylation in mammalian cells. RESTART was applied to nonsense mutations i...

Interesting talk by Chengqi Yi at the 5th Virtual @chembiotalks.bsky.social. He talked about site-specifically modifying RNA on the main example of an RNA-guided pseudouridine synthase. Cool applications for editing nonsense mutated RNA in disease. www.cell.com/molecular-ce...

We continue the 5th Virtual #ChemBioTalks with an exciting talk by Chengqi Yi, who talked about targeting and manipulating mutated #RNA to treat human diseases. Interesting insights into site-specific RNA modification. www.nature.com/articles/s41...
#ChemBio #ChemSky #DrugDiscovery

Single-cell multi-omics in the medicinal plant Catharanthus roseus - Nature Chemical Biology The medicinal plant Catharanthus roseus is a source of leading anticancer drugs. The monoterpene indole alkaloid (MIA) biosynthetic pathway in C. roseus has now been analyzed using a complementary, multi-omics, single-cell approach. This identified clusters of genes involved in MIA biosynthesis and cell-type-specific partitioning in the MIA biosynthetic pathway.

Great talk by @oconnorlab.bsky.social at the 5th Virtual @chembiotalks.bsky.social #ChemBioTalks.
She talked about the amazing diversity of natural products that plants make and the application of single-cell #multiomics technologies to deceipher their biosynthesis. www.nature.com/articles/s41...

The Virtual #ChemBioTalks get under way with our first keynote lecture by Sarah O'Connor (@oconnorlab.bsky.social), who gave exciting insights into, how plants can make diverse #NaturalProducts. onlinelibrary.wiley.com/doi/full/10....
#ChemBio #ChemSky

We get under way with the 5th Virtual #ChemBioTalks. We look forward to a great day of diverse topics in #ChemBio science.

If you attend and want to share your thoughts, make sure to link @chembiotalks.bsky.social and #ChemBioTalks.

We are getting ready for the 5th Virtual #ChemBioTalks. Very excited for a full day of exciting #ChemBio science.

If you experience any issues, please reach out at ChemBioTalks@gmail.com