Jim Boonyaratanakornkit

The full manuscript is here: www.nature.com/articles/s41...

A SERENDIPITOUS PATH TO DISCOVERING A POTENT MONOCLONAL ANTIBODY (mAb) FOR THE TREATMENT OF HUMAN METAPNEUMOVIRUS (HMPV) INFECTIONS Harris et al. discovered a rare but potent human mAb against HMPV that has a unique neutralizing mechanism. The antibody 4F11 has a high barrier against the development of resistance, has therapeuti...

Check out our new paper @fredhutch.org just published in
@natureportfolio.nature.com
Communications on a rare and unique antibody that could be used to treat a common respiratory virus called HMPV. And for the "untold story" behind the paper, here's more at go.nature.com/4bLBmim

The full manuscript is at: www.nature.com/articles/s41...

Thanks @medscape.com and Dr. Gholap for summarizing our article so nicely

This study was supported by the Amy Strelzer Manasevit award from @nmdp-org.bsky.social

We found that lower serum neutralizing antibodies were correlated with increased risk for RSV infection after transplant.

Respiratory Syncytial Virus in Hematopoietic Cell Transplant Recipients: Clinical and Humoral Risk Factors for Infection Two major findings were found from a prospective cohort of hematopoietic stem cell transplant recipients. 1) There is a significant correlation between imm

Check out our new paper on RSV in stem cell transplant patients @fredhutch.org in @ofidjournal.bsky.social tinyurl.com/2ktkvmv8 RSV is a respiratory virus that can cause severe lung disease in immunocompromised individuals.

We found protective antibodies targeting the viral protein complex gH/gL. The results could guide vaccine and immunotherapy design.

Monoclonal neutralizing antibodies elicited by infection with Kaposi sarcoma-associated herpesvirus reveal critical sites of vulnerability on gH/gL Author summary KSHV is an oncogenic virus that can cause cancer in infected individuals. The virus is most prevalent in sub-Saharan Africa and in men who have sex with men. It is possible this virus c...

Check out our new paper on Kaposi sarcoma-associated herpes virus (KSHV) in @plos.org Pathogens. Collaborative effort with the McGuire, Phipps, and Pancera labs @fredhutch.org. KSHV is a common herpes virus that can cause cancer journals.plos.org/plospathogen...

We found protective antibodies targeting the viral protein complex gH/gL. The results could guide vaccine and immunotherapy design.

Fred Hutchinson Cancer Center Fred Hutch is dedicated to the elimination of cancer and related diseases as causes of human suffering and death.

Our lab has a job opening for a research technician level I or II. Check out the posting and consider applying or referring someone you know @fredhutch.org
careers-fhcrc.icims.com/jobs/30351/r...?

Lab friendsgiving @fredhutch.org steam plant. We're grateful for the opportunity to do impactful science. We're grateful for each other. And we're so grateful for a future new lab baby. We made customized science onesies!

Respiratory Virus Infections and Pulmonary Impairment after Allogeneic Hematopoietic Cell Transplantation - PubMed RVI after HCT, particularly those caused by RSV, PIV-3 and influenza, increase the risk of pulmonary impairment and mortality. These infections should be targeted for specific anti-viral approaches an...

Key paper on the impact of respiratory viral infections on lung function in bone marrow transplant patients published by my colleagues @fredhutch.org pubmed.ncbi.nlm.nih.gov/41027579/

Cheers to Chandler! Thanks for helping set up the @fredhutch.bsky.social VIDD-Clinical Research Center. Best wishes at OHSU. Looking forward to seeing the great things you will do there.

Walked up to my office the other day and this made me smile. Thanks lab, you guys are awesome @fredhutch.bsky.social

Obliteride 5k! #formydad #curecancerfaster #research @obliteride.bsky.social @fredhutch.bsky.social

I'm riding in the @obliteride.bsky.social this weekend to support cancer research and care @fredhutch.bsky.social. Check out my page and, if you'd like, make a donation that will fuel cancer research.
secure.fredhutch.org/goto/Jim_Boon

Fred Hutch Cancer Center announces 2025 Evergreen Fund awardees Fred Hutch Cancer Center announces 2025 Evergreen Fund awardees, nine Fred Hutch researchers receive funding totaling $1.175 million for projects with commercial partnership potential.

Academic/industry partnerships @fredhutch.bsky.social through the Evergreen Fund drive innovation, collaboration, and research with real world impact. Grateful for the opportunity to accelerate antibody development to respiratory viruses for our transplant community
www.fredhutch.org/en/news/rele...

This antibody has a unique mechanism of action which we characterize structurally. We also pressure tested our antibody for the development of resistance. It's possible, but it comes at a cost for the virus.

DEVELOPMENT OF A POTENT MONOCLONAL ANTIBODY FOR TREATMENT OF HUMAN METAPNEUMOVIRUS INFECTIONS Human metapneumovirus (HMPV) is a major cause of respiratory infections, particularly among vulnerable populations, yet effective therapeutics remain unavailable. Monoclonal antibodies (mAbs) offer a ...

Check out what's new from our lab @fredhutch.bsky.social www.biorxiv.org/content/10.1... with 1-minute audio summary sciencecast.org/casts/0aqdo7... We discovered a highly potent antibody that can be used as prevention and treatment for a common respiratory virus called human metapneumovirus.

Jim Boonyaratanakornkit Help Fred Hutch Cancer Center advance innovative research. Donate today!

I'm riding my single gear bike (donated by my brother) over the hills of Seattle in the @obliteride.bsky.social on August 9th to support the @fredhutch.bsky.social Cancer Center, where I work. Below is my personal page. If you would like, you can donate. My best. secure.fredhutch.org/site/TR?px=1...

Fred Hutchinson Cancer Center Fred Hutch is dedicated to the elimination of cancer and related diseases as causes of human suffering and death.

Are you a workstudy college student or know one who is interested in a career in the biological sciences? Our lab has a position open for a lab aide. Application here: careers-fhcrc.icims.com/jobs/29313/l...

Lab website: research.fredhutch.org/boonyaratana...

Former director Francis Collins retires from NIH, urging 'respect' for embattled workers Francis Collins, former longtime director of the National Institutes of Health, announced Saturday that he has retired

Francis Collins, former longtime director of the National Institutes of Health, announced Saturday that he has retired

www.statnews.com/2025/03/01/n...

Flu deaths now exceeding COVID-19 deaths Public health experts worry about low vaccination uptake and that the season is far from over.

Flu season isn't over yet, & it's important for kids & adults to get vaccinated. “With COVID-19, we got used to the idea that the very old are the only people who are at risk for getting seriously ill," UCSF's Dr. Peter Chin-Hong says. But with flu, "it's... also the very young.”
ucsfh.org/4i1baA0

Thanks for a fabulous and productive scientific, clinical, and patient centered Tandem2025 conference by @astct.bsky.social we’ll miss you Hawaii. Lab dinner at the beach before we return to Seattle.

Great talk and title by Elizabeth Eubanks “Raising the Epstein Barr” from @dukemedschool.bsky.social @astct.bsky.social on therapies for relapsed refractory EBV post-transplant lymphoproliferative disease. Calling on Andy McGuire Lab @fredhutch.bsky.social to develop your therapeutic antibodies!

So good to see you and catch up with you @cgtgaithersburg.bsky.social about science and life

Interesting results presented by Elizabeth Krantz from @joshhillmd.bsky.social team @fredhutch.bsky.social @astct.bsky.social Tandem2025. Overall antibody levels are low in CAR T recipients. Re-vaccination is important. The Boonya lab collaborated on the B cell analysis.

Highlights from Justine Ross’ presentation from @cityofhope.bsky.social on RSV infections at Tandem2025 @astct.bsky.social 1) most respiratory viral infections occur during months 1-3 post-CAR T-cell therapy; 2) we need studies on RSV mAbs and vaccines in transplant and cell therapy recipients

Engaging talk by Jen Adair @fredhutch.bsky.social Tandem2025 @astct.bsky.social on efforts to make cell and gene therapy available in low and middle income countries. Academic centers need to step up. Great to see my friend @cgtgaithersburg.bsky.social in the Global Gene Therapy Initiative