Samantha (Ji Soo) Yoon, PhD

Hyperinsulinaemia as a cause of obesity and cardiometabolic diseases Nature Reviews Endocrinology, Published online: 09 March 2026; doi:10.1038/s41574-026-01240-1This Review outlines the potential role of hyperinsulinaemia as an independent driver of obesity and obesity-related conditions. Evidence regarding the potential causes of hyperinsulinaemia are summarized, and key research gaps are highlighted.

New content online: Hyperinsulinaemia as a cause of obesity and cardiometabolic diseases

We are happy to announce the Second Edition of our #AdiposeBiology Conference in Montreal, Oct 7-9, 2026! We are coming back with an incredible speakers line-up!
Visit adiposebiology.com to register!
#ABC2026 @sablesys.bsky.social @kazaklab.bsky.social @beaudrj.bsky.social @sunglab.bsky.social

A catecholamine-independent pathway controlling adaptive adipocyte lipolysis - Nature Metabolism Stable adipocytes resist lipolysis in healthy states but are highly susceptible to a catecholamine-independent, neurosystemic pathway-driven catabolic state.

RESEARCH |
@schellerlab.bsky.social
(WUSTL, US)

Stable adipocytes resist lipolysis in healthy states but are highly susceptible to a catecholamine-independent, neurosystemic pathway-driven catabolic state🧪

Sex steroids, SHBG and type 2 diabetes in women: what do we really know? - Diabetologia Androgens and oestrogens differentially regulate metabolic processes that impact the development of type 2 diabetes in women. The biological actions of these sex steroids are, however, dependent on th...

Review underscores how androgens, oestrogens and #SHBG shape key metabolic pathways in #women, highlighting sex-specific type 2 diabetes risk and helping guide future, women-focused research. #Type2Diabetes #SexSteroids #Metabolism #WomensHealth #SHBG
link.springer.com/article/10.1...

Lipedema: a chronic adipose tissue disease Lipedema is a non-inflammatory disorder of subcutaneous fat mainly affecting women, manifesting as non-pitting, diffuse fat accumulation in legs, hips, and upper arms. It progresses through stages: stage 1 has even skin with small, rice-grain-sized fat nodules; stage 2 features uneven, larger fat nodules and fibrosis; stage 3 causes skin deformity from massive fat extrusions. Genome-wide association studies (GWAS) link polymorphisms in VEGFA, GRB14-COBLL1, and other loci related to increased waist-to-hip ratio, and functionally connect vessel formation and lipid storage.

ONLINE NOW: Lipedema: a chronic adipose tissue disease

Oestrogen changes at menopause: insights into obesity-associated breast risk and outcomes Nature Reviews Endocrinology, Published online: 02 December 2025; doi:10.1038/s41574-025-01208-7Oestrogen levels change after menopause and with weight gain above the normal BMI category, both of which can affect breast cancer risk and outcomes. This Review explores the current understanding of these associations.

ICYMI: New content online: Oestrogen changes at menopause: insights into obesity-associated breast risk and outcomes

#1 Islets in a Pod with Dr. Patrick MacDonald YouTube video by CIRTN-R2FIC

CIRTN-R2FIC is currently running in Toronto its 4th Annual Meeting. During this meeting we have launched our mini interview series called "Islets in a Pod" ! Our first interview is with Dr. Patrick MacDonald from the University of Alberta.
youtu.be/UlHn_1Fz3ck?...

The 🇨🇦 Standing Committee on Science and Research passed a modified resolution this afternoon that the requested ricouncil applicant and reviewer data can be aggregated and anonymized. Thanks to the many researchers who signed letters pointing out legitimate data privacy concerns. 👏👏

Open Letter to Protect Tri-Council EDI Data Why do we need urgent action to protect our data? The mandate of the House of Commons Standing Committee on Science and Research is to review and report on topics relating to science and research in ...

Yes! Contact them and sign this petition here —it’s not just about EDI data! So much personally identifying information for applicants and reviewers will not be protected!
docs.google.com/forms/d/e/1F...

Canadian researchers should be aware the there is a motion before the Parliamentary Standing Committee on Science and Research to force Tricouncils to hand over disaggregated peer review data on all applications:
Applicant names, profiles, demographics
Reviewers names, profiles, comments, and scores

Congratulations to Dr. Taylor Scheidl, who successfully defended her PhD thesis last week! 🎉🎉🎉 Dr. Scheidl (@taylorscheidl.bsky.social) is the Thompson lab's first PhD graduate, and she will continue in her research career as a postdoc at the University of Alberta.

Health of adipose tissue: oestrogen matters Nature Reviews Endocrinology, Published online: 26 September 2025; doi:10.1038/s41574-025-01180-2Oestrogen is a key regulator in many metabolic processes, particularly in adipose tissue. This Review discusses the role of oestrogen in adipose tissue metabolism and its wider implications for systemic metabolic health.

New content online: Health of adipose tissue: oestrogen matters

Ending publication bias: A values-based approach to surface null and negative results Sharing knowledge is a fundamental principle within the scientific community, yet null and negative results are still being underreported. This Consensus View discusses the problem of such publication...

Sharing knowledge is a fundamental principle within the scientific community, yet null and negative results are still being underreported. @scurry.bsky.social &co present a roadmap to a solution that has a role for everyone in the scientific community 🧪 #Academicsky #reproducibility
plos.io/3VwaU2O

AVID mouse: A versatile platform for real-time, multiscale ATP imaging and spatial systems metabolism analysis in living mice Ohnishi et al. present the AVID mouse, which enables real-time, multiscale imaging of ATP dynamics in vivo across organs and cell types. This platform reveals spatially heterogeneous changes in energy metabolism during both physiological conditions and pathological states such as myocardial infarction, enabling systems-level analysis of metabolic regulation.

AVID mouse: A versatile platform for real-time, multiscale ATP imaging and spatial systems metabolism analysis in living mice

Illustration of a magnifying glass below text that reads "Freedom to research." Unlock Education campaign logo and "Education2025.ca" URL below the magnifying glass.

In Canada, proposed cuts of 15% across the federal government would have a dramatic effect on already globally decimated research & science.

Join Canada's research & science community and tell PM Mark Carney to preserve the funding promised in 2024.

Send a letter: win.newmode.net/canadianasso...

It's also the first manuscript that I'm a co-author on since starting my postdoc :)

Congratulations to Taylor Scheidl, the senior PhD student in the Thompson lab, on her new preprint 🎉 She showed that offspring born to obese dams are more likely to become obese due to more proliferation in early-life adipose progenitors, which leads to higher adipocyte numbers.

Opening a PDF these days is so weird. Yes, I know it's a long document. No, I don't want an AI summary, it's literally part of my job to read the long document and understand it, how do I make you go away? 😂

📢 Don’t miss the next Early Career Academy #Webinar! Prof. Kirsty Spalding ( @ki.se ) will present a new topic: “Mapping human brown fat: cellular architecture & metabolic implications”.

🗓 2 Sept 2025 | ⏰16:30 CEST

Register now 👉 us06web.zoom.us/meeting/regi...

#earlycareer #metabolichealth

Image of Toronto

JOB ALERT 🚨 We are hiring TWO principal investigators in cell, molecular, systems, or chemical biology in Toronto, Canada at @sinaihealth.bsky.social. We provide a generous startup, fully funded salary and academic appointment at U of Toronto.

www.nature.com/naturecareer...

Please repost!

Hey everyone who signed the letter about increasing funding for research in Canada, you can fill in this consultation and write in "Double Tri-council funding to help secure Canadian Research Sovereignty" as an option under "other" for the first question...

The government of Canada has a questionnaire about it's new budget. Most of the given options are conservative (because this is a conservative government) but there are some that aren't, and you can write in your own responses.
www.canada.ca/en/departmen...

Edmonton

Official posting coming soon, but here's a heads-up:

#Postdoc Opportunity for individuals with an interest in advancing the understanding of pancreatic islet hormones in health and #diabetes. Diverse backgrounds, skill sets and experiences are welcome!

www.bcell.org

Bringing this thread back since this paper is currently featured as the Endocrinology Article of the Week! 🎉This paper was the result of years of hard work during my PhD and it wouldn't have been possible without the excellent mentorship from Francis and the collaborative efforts of all co-authors.

NPAS4 Depletion in POMC Neurons Protects From Obesity and Alters the Feeding-regulated Transcriptome in Male Mice

Excited to share that our recent paper is featured as the Endocrinology Article of the Week! @samanthajsyoon.bsky.social

We are launching a new initiative to support experimental design, data management/analysis and bioinformatics. Early days yet, but check it out here.

www.bcell.org/adi-datasci....

Selective remodelling of the adipose niche in obesity and weight loss - Nature An atlas study of adipose tissue in people with obesity undergoing weight loss and their lean counterparts reveals that weight loss reduces cell senescence but cannot reverse all the metabolic problem...

New single-nucleus and spatial datasets offer unprecedented insights into the basis of #obesity associated adipose tissue dysfunction and its reversal by #weightloss and are a key resource for mechanistic and therapeutic exploration www.nature.com/articles/s41...

Come join us in Vancouver! Exciting opportunity for a more senior investigator researching new regenerative medicine approaches for Type 1 diabetes. $8M in funding for successful candidate research.ubc.ca/media/file/j...

📣Don't miss our second seminar on June 5th with @shanaadise.bsky.social sharing her work on food behavior and eating choices 🧠🥪🍓! Imane Hadj-Aissa from @ulaval.ca
will be our student presenter.

🔗Register here to ge the zoom link: forms.gle/nvcWTK7BtwSj...
#Science #Metabolism #behavior