Matthew Schmitz

Thanks to everyone who helped get this to a state where it could be shared! It's been one of those "five year journey" projects...

Comparison of the timing and expansion of progenitors across brain regions, and the many genes involved.

A statistical machine learning model (ANTIPODE) that integrates single cell data across species by accounting for differential expression at the same time as doing clustering.

highlights include:
A meta-atlas and taxonomy of the initial classes of cell types across the entire developing brain of human, macaque and mouse.

ANTIPODE Provides a Global View of Cell Type Homology and Transcriptomic Divergence in the Developing Mammalian Brain Diverse neurons and glia are generated in conserved spatial and temporal sequences during mammalian brain development. Divergence in gene regulatory networks can alter brain composition, scaling, timi...

Relieved to finally post my whole developing brain evolutionary "theory of everything" preprint!

www.biorxiv.org/content/10.1...

This is also what it's like to finish a cortical layer dissection...

Congrats, cool findings! I will say that from your original clickbait post I suspected it to be AI-generated garbage haha. Gotta be careful of how you represent your work and the views of the field to the public!

CREsted: modeling genomic and synthetic cell type-specific enhancers across tissues and species Sequence-based deep learning models have become the state of the art for the analysis of the genomic regulatory code. Particularly for transcriptional enhancers, deep learning models excel at decipher...

Very proud of two new preprints from the lab:
1) CREsted: to train sequence-to-function deep learning models on scATAC-seq atlases, and use them to decipher enhancer logic and design synthetic enhancers. This has been a wonderful lab-wide collaborative effort. www.biorxiv.org/content/10.1...

What a robust and slightly threatening solution for demuxing, doublet detection,etc for multiplex single cell genomics experiments!

No on cloture, no on the bill!

Wanna save the taxpayer money?

Don’t buy any Teslas.

Pleasure to co-edit this issue of Current Opinion on human genetic origins with @steinlab.bsky.social:

www.sciencedirect.com/special-issu...

Amidst the chaos, my partner was featured in this WaPo article about one more way that the administration is undermining the future of American Government www.washingtonpost.com/politics/202...

So that's kinda fun right? 🥲😭

It's sick irony that DOGE is the most incompetent government agency by far because it's staffed by a bunch of antidiversity hires whose only qualification is the color of their ideology

We need to make sure that everyone understands how important science is for EVERYONE not just for scientists...

We know by looking at the demographics of STEM faculty the system is biased against all sorts of people. With the murder of diversity supplements etc, what are we doing as a field to ensure a future of diverse people and ideas in science?

@chanzuckerberg.bsky.social why? If you're mostly privately funded, why would you make it your choice to join the segregationists? Please walk it back-back and reinstate your DEI programs.

www.theguardian.com/technology/2...

cortical organoid [image credit: O. Leonardi, who is leading this collaborative project]

First post on this platform 👋. Glad to reconnect with old friends, and also learn from new contacts. Will post about intersecting themes: human evolution, genetics (esp. aDNA), neuroscience & cognition. Currently focusing on brain organoids and early developmental changes that may have had an impact

Who knew hyenas were feliforms?! I always had them pegged for canidae 🧪 (phylogeny from carnivoran Wikipedia)