Organization of the Yeast Seipin Complex Reveals Differential Recruitment of Regulatory Proteins Lipid droplets (LDs) are neutral lipid storage organelles that emerge from the endoplasmic reticulum (ER). Their assembly occurs in ER regions enriched with seipin which, through its homooligomeric ri...

And it's out!
Some nice biochemistry reveals how the yeast Seipin compelx organizes in vivo across LD formation
www.biorxiv.org/content/10.1...

I am presenting!! Come hear about lipid droplet biogenesis and the protein that makes it all happen, seipin.

Life Sciences Symposium 2025 - ScienceAbroad For details>>

Come hear what amazing science is being done by Israeli scientists in Israel and abroad! Oh, and I will also be giving a talk on Lipid droplets!!🤩🤩
www.scienceabroad.org.il/life-science...

Mentors play such an important role in the career and confidence of budding scientists...

Many congratulations to Rebecca and Erik, winners of the first Dunn School Marvellous Mentor Award. Another great initiative by our student association!

www.path.ox.ac.uk/news-article...

Neutral lipids restrict the mobility of broken DNA molecules during comet assays This study reveals that neutral lipids (NL), naturally present in cells, become trapped within genomic DNA as a consequence of the standard execution of the comet assay, a technique used to measure D...

New from
@MorieLAB.bsky.social!
Neutral Lipids restrict DNA mobility!!
1. This has important implications for DNA repair in vivo,
2. also in vitro when you measure DNA breaks using the comet assay, beware!
3. And, we provide a fast new protocol overcoming this issue 😍

doi.org/10.1111/boc....

Excited to be giving a talk tomorrow at Karolinska. If anyone is in the area, do come check it out!
news.ki.se/calendar/sem...

In ancient Egypt, people drank low alcohol beer and wine to avoid the parasites in "raw water." The old graves, which I excavate, are full of children who died from diseases we now can vaccinate against. You are ghouls for promoting this garbage.

Tonight is the ‘lluvia de peluches’ at Real Betis. The annual tradition of stuffed toys thrown on to the pitch and collected for disadvantaged children ahead of Christmas. An estimated 15,000 toys are expected for collection.

You are all alone

SOS PAGE

The origins of the Guinness stout yeast - Communications Biology A genomic analysis of 22 S. cereviseae yeast strains used in beer brewing suggest that yeast used to brew Guinness form a distinct evolutionary sub-clade, and that the modern-day Guinness yeast is clo...

Wonderful use of science

www.nature.com/articles/s42...

The Bison or the car?

Proposed model of CYP51A1 recognition by SPP. In cells, the lanosterol demethylase CYP51A1 can exist in two distinct conformations, with only one conformation being recognized for membrane protein quality control. The early recognition event by SPP consists of an N-terminal cleavage within the AH of the substrate. This generates a truncated version of CYP51A1 that is subsequently recognized by the RNF185–MBRL E3 ubiquitin ligase complex, extracted from the ER membrane and degraded by the cytosolic proteasomes. APH, amphipathic helix.

Nikita Sergejevs, Pedro Carvalho and colleagues find that that the intramembrane protease SPP conducts topology surveillance of CYP51A1 by initiating quality control of incorrectly inserted molecules.
Highlight: journals.biologists.com/jcs/article/...
Article: journals.biologists.com/jcs/article/...