Lab of Fish Immunology

📢 Zajímá vás, jak zdravotní aspekty ryb propojuje věda s každodenním talířem? 🍽️🐟 více zde 👉 www.avcr.cz/cs/pro-verej...

Wonderful evening while visiting our colleagues at Nihon Uni in Tokyo — great company, warm hospitality, and amazing food. Thank you so much for having us. 🙏🙂

Single-cell RNA sequencing reveals influences of rearing environment on cellular immunity in brown trout (Salmo trutta) The ability to profile gene expression at the single cell level can offer unprecedented insight into the vertebrate immune system. While such profiling of non-model organisms can present unique challe...

And then there is this preprint @biorxivpreprint.bsky.social, one I’m pretty excited about. A single cell sequencing atlas of a salmonid immune system, from brown trout. Weird B-cell/Neutrophil crossover cluster - what do immunologists think?
🐟 🔬 🧬 🦠 🧫 🌎

www.biorxiv.org/content/10.1...

Having a great time at the 5th ISFSI in Tainan, Taiwan! 🌏✨ Fantastic talks, inspiring science, and wonderful people — already looking forward to the next one! 🇹🇼🐟 #ISFSI2025 #Tainan #FisheriesScience #Aquaculture

Diverging fish biodiversity trends in cold and warm rivers and streams - Nature In the past three decades, fish abundance, richness and uniqueness have diverged across cold and warm streams, and the effects on native fish communities of stream warming and increases in introduced fishes have magnified each other.

Nature research paper: Diverging fish biodiversity trends in cold and warm rivers and streams

go.nature.com/42JFObR

Great vibes at yesterday's project meeting with our awesome colleagues @CatrinUP @IFrebort
and @JihoceskaUni💡🧬 So many sparks flying already-this is gonna be fun! Go Barley go! 🚀🌾

Just having a great time at EAFP2025 in Crete ✈️. Talks delivered, briliant food, people, colleagues. Can't wait for the next one. 🇮🇸

We were delighted to welcome our colleagues visiting us from 🇯🇵
Nihon Uni in Tokio
and Fukui Prefectural Uni
🤓 ありがとう ございま. It was a pleasure having you here with us. See u soon in Japan guys ✈️

Automatic phenotyping using exhaustive projection pursuit - Communications Biology An automated tool (EPP) identifies distinct cell phenotypes in flow cytometry data through optimized 2D gating as shown in 4 published datasets. EPP’ C++ code integrates with any software, as demonstr...

An automated tool (EPP) identifies distinct cell phenotypes in flow cytometry data through optimized 2D gating as shown in 4 published datasets. EPP\u2019s C++ code integrates with any software, as demonstrated in MATLAB with FlowJo.

@black-softail.net

www.nature.com/articles/s42...

Did you ever wonder what insights hide in the multiplets that are usually discarded in flow cytometry? 🫧 Find out in the first publication of my PhD, now out in Nature Methods! www.nature.com/articles/s41... (1/4)

Thanks Sheena it’s great to get some clearly explained immunology out into the world

Multiple Horizontal Transfers of Immune Genes Between Distantly Related Teleost Fishes Abstract. Horizontal gene transfer (HGT) is less frequent in eukaryotes than in prokaryotes, yet can have strong functional implications and was proposed a

Policarpo et al. use phylogenetic and synteny data to identify 19 teleost-to-teleost horizontal gene transfers, involving genes linked to immunity or pore formation; this suggests eukaryote-to-eukaryote HGT has shaped teleost evolution.

🔗 doi.org/10.1093/molbev/msaf107

#evolbio #molbio #fish

Secretory IgM regulates gut microbiota homeostasis and metabolism - Nature Microbiology Rainbow trout with depleted secretory IgM reveal interesting insights into the elusive role of this immunoglobulin in maintaining gut microbiota.

Our latest paper is now out. A long standing collaboration with the Sunyer lab where our teams show the requirement for secretory IgM in the gut mucosa to control microbiota homeostasis and metabolism. Enjoy! #sIgM #mucosalimmunology www.nature.com/articles/s41...

From Genes to Pathways: A Curated Gene Approach to Accurate Pathway Reconstruction in Teleost Fish Transcriptomics A curated gene list for teleost fish transcriptomics enhances the interpretation of high volumes of data by focusing on key biological processes. This resource bridges gaps in automated annotations, ....

From Genes to Pathways: A Curated Gene Approach to Accurate Pathway Reconstruction in Teleost Fish Transcriptomics

Hererra et al. 2025

Presents a curated gene list tailored for teleost fish transcriptomics

doi.org/10.1002/jez....

Hiding in plain sight: A new lymphoid organ discovered in #zebrafish. Mohamed Bakr and David Langenau discuss new work from @zebrafish007.bsky.social @zebrafishmk.bsky.social and colleagues (rupress.org/jem/article/...) in Insights: rupress.org/jem/article/...

Three research groups@fbndummerstorf Uni of Vet in Hannover and Faculty of Fisheries from Vodňany met in our lab to do some science together. Such a great moments a lot of sampling we did 🐟🧪🧪🧪🫡 and also became TV stars 😅😅

Deep-tissue transcriptomics and subcellular imaging at high spatial resolution Limited color channels in fluorescence microscopy have long constrained spatial analysis in biological specimens. Here, we introduce cycle Hybridization Chain Reaction (HCR), a method that integrates ...

Truly amazing 👏👏👏👏 Deep-tissue transcriptomics and subcellular imaging at high spatial resolution | Science www.science.org/doi/10.1126/...

KORYTAR LAB Welcome to the Lab of Fish Immunology at the Biology Centre CAS

Today we launched new lab webpage please check for any info
sites.google.com/view/korytar...

Just having a great time full of hard work at Friedrich Loeffler Institute
🏢. Fish cells are the best 🐟🐟🐟🧪🧪🧪

Does a cell’s gene expression always reflect its function? Transcriptionally similar neurons can be functionally diverse.

There is a disconnect between the current molecular, morphological and functional descriptions of cells in most nervous systems

https://go.nature.com/4jUeXRq

Drawing of angler fish on black background

February issue now online: www.nature.com/nri/volumes/...
Cover image inspired by the Perspective 'Understanding vertebrate immunity through comparative immunology' bit.ly/3EoZqJ1 by Thomas Boehm
#immunosky #immunology

Unbelievable 👏👏👏 Fish can tell many things about us...

Fish gills and human ears share the same genetic blueprint Evolutionarily conserved molecular program used to form gills and ears.

How did human ears evolve?

https://go.nature.com/4hpXzCl

Innate Immune Memory is Stimulus Specific Innate immune memory (also termed trained immunity) is defined in part by its ability to cross-protect against heterologous pathogens, and can be generated by many different stimuli, suggesting a “uni...

Cool work, very smart are these macrophage guys 👏👏
www.biorxiv.org/content/10.1...

B cell subsets have different capacities for phagocytosis and subsequent presentation of antigen to cognate T cells https://www.biorxiv.org/content/10.1101/2025.01.28.635276v1

Went for "shopping" samples downstairs to @FishProtLab
at the Biology Centre CAS 😅🛒🛒 #movingstuff to 🆕lab...

This year is gonna be fun! 😎🍸☀️✈️ 🇦🇹🇬🇷🇹🇼🇳🇱

Yesterday we welcomed this 🆒 old/new beauty in our lab 🤘. Can't wait to make the plots #flowcytometry