Rodrigo Romero Rangel

Excellent, so glad to see this out. Such a powerful set of new tools to play around with. Congrats Ventura Lab!

Engineered extrachromosomal oncogene amplifications promote tumorigenesis - Nature Large extrachromosomal DNAs are engineered using a CRISPR- and Cre–loxP-based approach and shown to drive cancer in mouse models, with potential applications in determining the role of oncogene a...

🧪1/ 🚨New paper on ecDNAs from our lab!
We reveal a strategy to engineer extrachromosomal DNA (ecDNA) amplifications in cells & mice. Let's dive in! Let’s dive in! 🧵👇
www.nature.com/articles/s41...

Ageing limits stemness and tumorigenesis by reprogramming iron homeostasis - Nature Studies using mouse models of lung adenocarcinoma identify an association between age, iron homeostasis and tumour initiation potential that involves NUPR1 and lipocalin-2.

Really interesting paper on how aging limits lung cancer progression by the Tammela lab www.nature.com/articles/s41...

Our Paper out in @natureportfolio.bsky.social with correct link www.nature.com/articles/s41...

I’m excited to share new work out of the lab in Nature Metabolism today on the impact of tumor-relevant glucose concentrations on the response to pyrimidine synthesis inhibitors. t.co/9hOGW4x97T. PDF: rdcu.be/d1vkV

It gets better right? RIGHT?!

Can I be included as well? :)

Very excited to share our latest publication on the role of NOTCH1 in sexual dimorphism in liver cancer and published in
Cancer Discovery! Super proud of Katie Lindblad for leading this study as part of her outstanding PhD work.

A platform for multimodal in vivo pooled genetic screens reveals regulators of liver function Organ function requires coordinated activities of thousands of genes in distinct, spatially organized cell types. Understanding the basis of emergent tissue function requires approaches to dissect the...

In collaboration with Reuben Saunders, @jswlab.bsky.social, and Xiaowei Zhuang, we are very excited to release Perturb-Multi: a platform for pooled multimodal genetic screens in intact mammalian tissue.

Check it out!
www.biorxiv.org/content/10.1...

Research Assistant II - Genetics at MD Anderson MD Anderson is Hiring! Search available jobs or submit your resume now by visiting this link. Please share with anyone you feel would be a great fit.

The Vaishnavi Lab is hiring a new RAII! Interested in learning more about mouse models of lung cancer? jobs.mdanderson.org/search/jobde... Please RT!
#lcsm #AcademicChatter

Gliocidin is a nicotinamide-mimetic prodrug that targets glioblastoma - Nature The prodrug gliocidin effectively kills glioblastoma cells by targeting de novo purine synthesis, improving survival in mouse models.

new out in Nature www.nature.com/articles/s41...

Very cool! Can’t wait to dig in. Congrats!

Dear new #science #STEM community-
@abireland.bsky.social and I are thrilled to share our latest. The basal cell changes everything for #SCLC #plasticity! Despite prevailing dogma, we now believe the basal cell is the most plausible origin for SCLC because:

This is great! Could I be added too, please?