Exciting news:
Our RNA community in @uniregensburg.bsky.social is set to grow!
We are opening a Junior Group Leader position in RNA biochemistry / ribonucleases / RNA stability. A great opportunity to start your own team within our collaborative RNA network.
Details & application 👇
Postdoc positions available in my lab in Aarhus, Denmark on 'Mammalian Nuclear RNA Production and Turnover Systems'. Please get in touch for further information or simply apply here:
mbg.au.dk/en/news-and-...
Join us 👇. Together with our CompBio and Proteomics platforms, we'd love to work with you on examining protein dynamics!
🚀 We’re hiring! The Structural Biology Platform is seeking a Project Leader to advance cryo-electron tomography and expand capabilities at the FMI. Join a vibrant research community at the interface of structural biology, cell biology & disease mechanisms. Apply at: www.fmi.ch/education-ca...
👩🔬 On February 11, to mark the International Day of Women and Girls in Science, we’re hosting a panel discussion on how scientific progress and gender equality can advance together. The panel brings together voices from academia, industry, and EDI. Join us for this important conversation!
#IDWGS
Now out in @currentbiology.bsky.social: neuroscientists in the lab of @felsenberg.bsky.social found that in fruit flies, re-tasting a sugar reward can weaken past memories, pointing to new ways to safely update harmful ones. www.fmi.ch/news-events/...
Very thankful for this thoughtful dispatch by @shaisrael.bsky.social sky.social and Moshe Parnas about our work. Learning and memory: Forgetting to remember: Current Biology www.cell.com/current-biol...
Our annual brochure “Year in Review” is out now! It highlights the FMI’s key scientific publications, major events, and facts & figures from 2025, a year that marked our 55th anniversary.
www.fmi.ch/news-events/...
Congratulations, Fiona!
Prof. Fiona Doetsch has been awarded the 2026 Louis-Jeantet Prize for Medicine!
Her discoveries reveal how neural stem cells support lifelong brain plasticity and repair. 🧠
Read more: www.biozentrum.unibas.ch/news/detail/...
RNA-binding proteins function through network effects, coordinately binding and weakly regulating many transcripts – or don’t they? Read our new preprint on how LIN28 controls developmental timing through only two targets, one mRNA, one miRNA. doi.org/10.64898/202...
Please repost - position of Head of Student & Postdoc Affairs available at our Institute in the heart of Europe (Basel, Switzerland) 👇
Read this inspiring perspectives coauthored by the Worm Resource directors and worm Nobel Laureates! 4 Nobel Prizes and how they were enabled by major NIH-supported research resources (the Caenorhabditis Genetics Center, WormBase, and WormAtlas) www.pnas.org/doi/10.1073/...
Switzerland is joining Horizon Europe!
We are uniting two research powerhouses.
For cutting-edge innovation that will boost our energy security, digital transformation, health and so much more.
Today is a good day for science, and for our EU-Switzerland partnership.
And we have another open position, this time with a focus on Genome Biology! Join a great community in Vienna to bring your research to the next level!
Now in @embojournal.org: Researchers in @labgrosshans.bsky.social & UCSC found that similar molecular machineries control daily circadian rhythms & developmental timing—showing that evolution can repurpose core timing systems to coordinate both daily cycles & growth. www.fmi.ch/news-events/...
Programme of the upcoming TriRhena Gene Regulation Club in Basel on November 5, 2025 https://www.ie-freiburg.mpg.de/gene-regulation-club
Here is the schedule for the next TriRhena Gene Regulation Club at the FMI @fmiscience.bsky.social in Basel 🇨🇭 next week (5 Nov 2025; 14:00-18:45).
Exciting topics ahead & we are looking forward to the #newPI talks by @julianeg.bsky.social (MPI) & Anupama Hemalatha (FMI).
www.ie-freiburg.mpg.de/grc
"[In C. elegans] researchers uncovered key principles of cell death and RNA interference [that] paved the way for new therapies and technologies. These breakthroughs were made not because they were sought by design, but because a few scientists, supported by public grants, followed their curiosity"
Nektarios Tavernarakis on why curiosity-driven research, not focusing on application, is fundamental to problem solving and requires government support in @emboreports.org doi.org/10.1038/s443...
Flying worms! www.science.org/content/arti... (And I always wondered how worm cuticular alae (= wings) got their name 😉)
🔬 Next in the NCCR RNA & Disease Seminar Series: Prof. Olivia Rissland (Univ. of Colorado School of Medicine, USA)!
📅 27.10. 16:30 – University of Bern, DCBP
📅 28.10. 15:00 – ETH Zurich, Hönggerberg
👉 More info: nccr-rna-and-disease.ch/education/nc...
@unibe.ch @ethz.ch @snf-fns.ch
For what it’s worth, The Wyoming Worm lab has funding for 5 years along with exciting projects with solid foundations. We are is still looking for capable, dedicated, and fun-to-work-with lab members at all career stages. davidfay@uwyo.edu
scholar.google.com/citations?us...
Fabulous @katb92.bsky.social was the lead on our side!
This invites speculations about the evolution of circadian vs. developmental clocks and the features that make the PER/LIN-42:CK1/KIN-20 module so central to different timing mechanisms – as discussed in the accompanying News & Views article @embojournal.org doi.org/10.1038/s443... . 8/n
Intriguingly, this tango also appears to happen in circadian clocks: while CK1 licenses PER for degradation, PER also regulates CK1 activity and its targeting of the CLOCK protein in the nucleus. 7/n
Indeed, KIN-20 exhibits dynamic localization to the nucleus – dependent on LIN-42 binding. We speculate that this may provide KIN-20 to access to additional substrates. 6/n
Animals lacking CK1/KIN-20 or its enzymatic activity are highly arrhythmic – in fact much more so than animals only lacking the LIN-42_CK1BD. This made us wonder whether the key function of the complex is regulation of KIN-20 by LIN-42, rather than the other way around. 5/n
LIN-42 co-immunoprecipitates KIN-20 – an orthologue of Casein Kinase 1delta/epsilon that also occurs in a complex with PER in mammals. The LT/SYQ region forms a CK1-binding domain (CK1BD) that also regulates CK1 activity. CK1 phosphorylates LIN-42. 4/n
Its most conserved feature are the PAS (PER/ARNT/SIM) domains – but we find them to be dispensable for rhythmic molting. Instead, a less conserved region previously termed LT/SYQ for an amino acid signature is required. 3/n
The C. elegans LIN-42 protein is orthologous to fly/mammalian PERIOD – but during development, oscillates with a 7-hr rather than a 24-hr period. It affects temporal cell identity and promotes rhythmic molting – but how, was unclear 2/n
