Jei Diwakar

After a long journey, I'm happy to share that my PhD work is finally published in Nature Communications. Grateful to all my co-authors!

SET1/MLL complexes control transcription independently of H3K4me3 Histone H3 lysine 4 trimethylation (H3K4me3) at gene promoters is thought to play a central role in gene transcription. H3K4 methylation is deposited by the SET1 (A/B) and MLL (1-4) multi-protein comp...

An early Christmas present for those interested in chromatin and transcription! Fantastic work from @au-ho-yu.bsky.social and @aleksszczurek.bsky.social . Thanks to Inge and Michiel for their help. Please repost!

www.biorxiv.org/content/10.6...

We are recuiting two new Associate Professors here in Oxford Biochemistry. Come join us! Reach out to me if you have any questions. Please repost! tinyurl.com/mr3m7bd3

🎤 Apply to speak @our TALENT FORUM by July 31!
Showcase YOUR research in Epigenetics & NucleicAcids @www.helmholtz-munich.de & connect with leading scientists

🧳Travel+accommodation covered if selected!
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#postdoc #career #groupleader #HelmholtzMunich #research

Thanks so much man! Hope all is well

PhD: officially wrapped up! 🎓
I successfully defended and couldn’t be more grateful! From bold projects to brilliant teammates @bonevlab.bsky.social - what an amazing journey. Huge thanks to everyone who shaped it, especially Boyan Bonev(@boyanbonev.bsky.social) & our lab.
Onwards 🚀

Neural stem cell epigenomes and fate bias are temporally coordinated during corticogenesis The cerebral cortex orchestrates complex cognitive functions, yet how its distinct temporal lineages are molecularly patterned during development remains unresolved. Here, we integrate single-cell tra...

Can a stem cell change its epigenome while proliferating? In collaboration with the lab of Amos Tanay, we demonstrate that yes, the epigenome of neural stem cells (NSCs) is continuously remodeled, across multiple layers, during mouse corticogenesis. 1/14
www.biorxiv.org/content/10.1...

Final Episode of the day completed! #podcast #roadtrip // @boyanbonev.bsky.social @bonevlab.bsky.social

3D Epigenome Evolution Underlies Divergent Gene Regulatory Programs in Primate Neural Development The expansion of the neocortex is a hallmark of human evolution and is closely linked to neural stem cell biology. Yet, the epigenetic mechanisms driving divergent gene regulation during primate neuro...

🚨New preprint from @bonevlab.bsky.social 🚨: What are the key epigenetic mechanisms that drive species-specific gene regulation during primate neurogenesis - and how do they contribute to the evolution of the human neocortex?
Here’s what we discovered 👇
www.biorxiv.org/content/10.1...

H3K4 methylation-promoted transcriptional memory ensures faithful zygotic genome activation and embryonic development In the life of a vertebrate embryo, gene expression is initiated for the first time at zygotic genome activation (ZGA). Maternally expressed transcription factors present in the embryo are essential f...

✨ Excited to share my latest preprint on how H3K4 methylation promotes transcriptional memory from gametes to embryos across a transcriptionally silent window — crucial for proper zygotic genome activation and development. 🐸🧬✨

📄 Check it out here:
doi.org/10.1101/2025...

👇 Highlights below