Cravedi Lab

Genetically modified pig liver keeps man alive until human organ transplant First time the procedure has been performed on a living person.

Genetically modified pig liver keeps man alive until human organ transplant www.nature.com/articles/d41...

Mechanistic insights from transcript analysis of long-term pig to non-human primate kidney xenografts Porcine xenografts are a potential future organ source. Limited short-term clinical studies have suggested different mechanisms in xenografts than all…

www.sciencedirect.com/science/arti...

Granzyme K sets complement in motion

Cytotoxic T cells enhance tissue inflammation by secreting proteases like GZMK to induce local complement activation
www.sciencedirect.com/science/arti...

Anti-CMV immunotoxin during ex vivo machine perfusion: are we ready for CMV-negative transplantation? Recent progress in the management and prevention of cytomegalovirus (CMV) infection has reduced the burden of CMV after organ transplantation (1). Low-risk CMV seropositive recipients (R+) who may nee...

Anti-CMV immunotoxin during ex vivo machine perfusion: are we ready for CMV-negative transplantation? - American Journal of Transplantation www.amjtransplant.org/article/S160...

Can low serum complement be used as an indicator of thrombotic microangiopathy in kidney transplant candidates with unknown diagnosis? Many patients reach kidney failure with unknown or misdiagnosed primary kidney disease. This is a major clinical issue because some native diseases, includ

Can low serum complement be used as an indicator of thrombotic microangiopathy in kidney transplant candidates with unknown diagnosis? url: academic.oup.com/joneph/artic...

Visual abstract to accompany article

🚨 Editor’s Choice 🚨
"Erythropoietin prolongs graft survival in mice by counteracting trained immunity," by Bin et al
www.amjtransplant.org/article/S160...
@cravedilab.bsky.social

B-cell maturation antigen-Targeted T-cell Engager Therapy Combined with B cell Depletion for Treatment of Refractory HLA Sensitization Preformed, high-titer anti-human leukocyte antigen (HLA) antibodies remain a major barrier to successful kidney transplantation, increasing the risk of early graft loss and prolong time on dialysis. D...

B-cell maturation antigen-Targeted T-cell Engager Therapy Combined with B cell Depletion for Treatment of Refractory HLA Sensitization - Kidney International www.kidney-international.org/article/S008...

Getting into the mood to review a grant

Recurrence of C3 Glomerulopathy and Immune Complex–Mediated Membranoproliferative Glomerulonephritis After #Kidney #Transplantation: Challenges and Opportunities

https://doi.org/10.1016/j.ekir.2025.11.008

#C3Glomerulopathy #KIRReview

Updates on Kidney Transplantation From the World Transplant Congress 2025
journals.lww.com/transplantjo...

On the balance of knowledge - Nature Reviews Immunology Ruslan Medzhitov shares his thoughts on the balance between generating data and developing theories in immunology, with a focus on exploring the rules that govern complex systems.

Very insightful read:
www.nature.com/articles/s41...

AlphaGenome is out in @nature.com today along with model weights! 🧬

📄 Paper: www.nature.com/articles/s41...

💻 Weights: github.com/google-deepm...

Getting here wasn’t a straight path. We discussed the story behind the model, paper & API in the following roundtable: youtu.be/V8lhUqKqzUc

Thomas Fogarty, 91, Who Helped Revolutionize Vascular Surgery, Dies

Thomas Fogarty, 91, Who Helped Revolutionize Vascular Surgery, Dies www.nytimes.com/2026/01/26/s...

Combined Anti-CD20/Anti-CD38 Therapy in Posttransplant Focal Segmental Glomerulosclerosis Recurrence: A Retrospective, International, Multicenter Study

journals.lww.com/transplantat...

Final funding bill for NIH pushes back against Trump cuts Measure gives agency slight boost and blocks multiyear awards and cuts to indirect costs

Final funding bill for NIH pushes back against Trump cuts | Science | AAAS www.science.org/content/arti...

B Cell Depletion in Glomerular Diseases: Not Always as Safe as We May Think B cell depletion with chimeric anti-CD20 monoclonal antibody rituximab has revolutionized the treatment of glomerular diseases. Obinutuzumab, a type II glycoengineered anti-CD20 humanized monoclonal a...

B Cell Depletion in Glomerular Diseases: Not Always as Safe as We May Think - Kidney Medicine

www.kidneymedicinejournal.org/article/S259...

Chronic kidney disease Globally, the prevalence of chronic kidney disease is estimated to be approximately 850 million cases, with approximately 4 million individuals needing kidney replacement therapy for kidney failure. B...

Chronic kidney disease - The Lancet www.thelancet.com/journals/lan...

Topography of the HLA-A protein enforces shared and convergent immunodominant B cell and antibody alloresponses in transplant recipients Donor-specific antibodies against mismatched HLA proteins cause allograft failure, but the structural epitopes recognized by these antibodies are not well defined. Killian et al. identify immunodomina...

Topography of the HLA-A protein enforces shared and convergent immunodominant B cell and antibody alloresponses in transplant recipients: Immunity www.cell.com/immunity/ful...

90 Minutes to Give Baby Luna a New Heart After eight years of training, Dr. Maureen McKiernan made her debut as the lead surgeon on an infant heart transplant — an operation on the edge of what’s possible.

After eight years of training, Dr. Maureen McKiernan had 90 minutes to get a beating heart inside a 6-month-old infant. It was her first heart transplant as the lead surgeon and her first ever in an infant. Here's a look at the steps in the milestone operation.

With all the excitement about AI giving us answers, we often forget that the real trick is to figure out what is the question.

Promoting Equity in Transplant Research by Addressing the Exclusion of Patients With Glomerular Disease Kidney transplantation remains the treatment of choice for patients with end-stage kidney disease (ESKD), offering superior survival and quality of life compared with dialysis.1 Despite improvements i...

Promoting Equity in Transplant Research by Addressing the Exclusion of Patients With Glomerular Disease -

Kidney International Reports www.kireports.org/article/S246...

When your PI presents your work

Reaching maturity: Thymic γδ T cell differentiation in mice and humans γδ T cell differentiation into specialized effector subsets during both early life and adulthood is reviewed.

Reaching maturity: Thymic γδ T cell differentiation in mice and humans | Science Immunology www.science.org/doi/10.1126/...

Short-term glyco-editing during machine perfusion permits ABO-incompatible transplantation in a human decedent model

Short-term glyco-editing during machine perfusion permits ABO-incompatible transplantation in a human decedent model

www.sciencedirect.com/science/arti...

Frontiers Publishing Partnerships | Increased Treg in Kidney Transplant Recipients With Erythrocytosis Dear Editors, Erythropoietin (EPO) is a glycoprotein hormone produced predominantly by the kidney in response to hypoxia. While widely known for its hematopo...

Increased Treg in Kidney Transplant Recipients With Erythrocytosis
www.frontierspartnerships.org/journals/tra...

Preprint: CD19-directed CAR-T-cell therapy can induce rapid, durable remission of severe, refractory cold-agglutinin AIHA and simultaneously improve coexisting APLAS and ITP on a favorable toxicity profile
papers.ssrn.com/sol3/papers....

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Can AI capture the mind-boggling complexity of a human cell? Researchers are competing to make “virtual cells” that could transform biomedicine by predicting gene activity and more

www.science.org/content/arti...

With winged legs, orchid mantis sets gliding record Camouflaged like a flower, these predators also have a getaway trick

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Kidney transplantation across ABO-H incompatibility in a recipient with Bombay blood group: A novel report The Bombay blood group is an exceptionally rare phenotype characterized by the absence of H antigen on red blood cells due to mutations in the FUT1 gene and absence of H substance in secretions from c...

Kidney transplantation across ABO-H incompatibility in a recipient with Bombay blood group: A novel report - American Journal of Transplantation www.amjtransplant.org/article/S160...