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Kavita Babu

@kavita-babu

C. elegans Neurobiologist | Assoc Prof at IISc Bangalore, India. Personal views

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15.11.2024
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Latest posts by Kavita Babu @kavita-babu

Thank you @biopatrika.bsky.social for spotlighting Navneet's work.

09.03.2026 12:38 πŸ‘ 2 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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Thank you Indian IISc and Souptika Das for highlighting this work. All credit to Navneet for leading this work with Nisha, Sharveri, Dimple and collaborators' Egemen and Askin. Funding thanks: DBT/WT India Alliance, ANRF and DBT. #CNSIISc iisc.ac.in/events/wormi...

28.02.2026 06:24 πŸ‘ 16 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0

Thanks very much.

23.02.2026 06:08 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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Neuromodulation of swarming behavior in Caenorhabditis elegans: Insights into the conserved role of calsyntenins | PNAS Collective animal behaviors arise from a complex interplay between internal physiological states and external environmental cues. In Caenorhabditis...

This study can now be found at www.pnas.org/doi/10.1073/...

21.02.2026 14:13 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

We have studied the underlying molecular mechanism and possible neurons involved in this behaviour. Congrats to all the authors and a big shoutout to Navneet who did a bulk of the heavy lifting. Do check out the cool videos! Funding thanks ANRF, DBT/Wellcome Trust India Alliance, DBT, CSIR and IISc.

21.02.2026 14:12 πŸ‘ 4 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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Neuromodulation of swarming behavior in Caenorhabditis elegans: Insights into the conserved role of calsyntenins | PNAS Collective animal behaviors arise from a complex interplay between internal physiological states and external environmental cues. In Caenorhabditis...

Very cool work by Navneet on collective behaviour in worms now out in @pnas.org. Congratulations to all the authors Nisha, Sharveri, Dimple and collaborators Sarıtekin and Aşkın Kocabaş. We show that calsyntenin mutants in C. elegans show a collective swarming behaviour. www.pnas.org/doi/10.1073/...

21.02.2026 14:12 πŸ‘ 15 πŸ” 1 πŸ’¬ 2 πŸ“Œ 0
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New Lancet study highlights UMass Chan’s Rabishield as safe and effective in preventing rabies A new study in The Lancet confirms a rabies monoclonal antibody therapy, co-developed by UMass Chan, is a safe alternative to existing rabies immune globulins.

New study in The Lancet confirms Rabishield, developed by UMass Chan in partnership with the Serum Institute of India, is a safe, effective alternative to older rabies treatments: direc.to/nLSh

In India, two people die of rabies every hour.

#rabies @thelancet.com @umassmedicine.bsky.social

26.09.2025 14:03 πŸ‘ 7 πŸ” 4 πŸ’¬ 0 πŸ“Œ 0
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Molecular Configuration, Regulation and Function of Heterochannel Electrical Synapses Neuron-specific expression of particular gap junction channel components defines the configuration and functional properties of electrical synapses. However, how a neuron utilises multiple, simultaneo...

Cool story by Atal et al from Abhishek's lab at @ncbsbangalore.bsky.social. Do have a read. www.biorxiv.org/content/10.1...

17.09.2025 16:49 πŸ‘ 2 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0

Many thanks to Zhitao and the DBT Wellcome Trust India Alliance for funding. n/n

23.08.2025 01:32 πŸ‘ 3 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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The claudin-like molecule CLC-3 regulates neuromuscular function in Caenorhabditis elegans by modulating cholinergic signalling Cell adhesion molecules (CAMs play important roles in neurons, contributing to nervous system development, synapse formation, and activity-dependent plasticity. Claudins, the cell-adhesion molecules k...

The last one is Aishwarya's work characterised the role of a C. elegans claudin in cholinergic signalling at the worm NMJ. Many thanks to Anusha, Haowen, Akankshya, Harinika and Jagan for helping with this work that can be found at www.biorxiv.org/content/10.1... 8/n

23.08.2025 01:32 πŸ‘ 5 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0

Thank you.

21.08.2025 05:54 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

Thanks much, Aakanksha.

21.08.2025 05:52 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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q.e.d Science Critical Thinking AI for constructive criticism and science evaluation

This was also an exciting paper for us because we got to pre-review it even before submission with q.e.d’s AI qedscience.com. really helpful and improved a lot!

20.08.2025 01:32 πŸ‘ 17 πŸ” 6 πŸ’¬ 2 πŸ“Œ 0

Thank you! It makes me want to pull my hair out too :)

21.08.2025 05:32 πŸ‘ 2 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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The results are in! We're excited to announce the awardees of the IBRO/SfN Travel Grants to attend #SfN25, who will present their work on a global stage & engage with the international neuroscience community

πŸ‘ Find out who they are: ibro.org/ibro-sfn-tra...

@sfn.org #neuroscience #conference

06.08.2025 09:05 πŸ‘ 3 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0
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IBRO Parenthood Grants cover various costs for early-career #neuroscientists, helping them stay active in their career while balancing the new parent life πŸ‘¨πŸΌ

Discover what's covered & apply by 15 AugπŸ‘‡
buff.ly/k0Fx2ah

#IBROinAsiaPacific #IBROinUSCanada #IBROinAfrica #IBROinLatAm #IBROinEurope

08.07.2025 09:00 πŸ‘ 5 πŸ” 3 πŸ’¬ 0 πŸ“Œ 0

Neuromodulation of Swarming Behavior in C. elegans: Insights into the Conserved role of Calsyntenins https://www.biorxiv.org/content/10.1101/2025.07.06.663344v1

07.07.2025 03:15 πŸ‘ 5 πŸ” 2 πŸ’¬ 0 πŸ“Œ 0
Neuromodulation of Swarming Behavior in C. elegans: Insights into the Conserved role of Calsyntenins Collective animal behaviors arise from a complex interplay between internal physiological states and external environmental cues. In Caenorhabditis elegans, favorable conditions promote dispersal, while stressors like food scarcity or overcrowding trigger aggregation. Here, we describe a distinct behavior termed as swarming, where C. elegans move and feed in aggregates despite abundant food availability. While environmental factors have been implicated in this behavior, the underlying genetic and molecular mechanisms remain unclear. We identify a novel role for the conserved calsyntenin protein CASY-1 in regulating swarming. Through genetic, behavioral, and optogenetic approaches, we show that CASY-1 functions in sensory neurons to modulate the neuropeptide pigment-dispersing factor (PDF) signaling. Mutants in casy-1 show impaired PDF-1 signaling and reduced inhibition of the serotonin pathway, a known regulator of social behaviors. This dysregulation, along with its associated mechanosensory and foraging defects, likely contributes to the swarming phenotype. Our findings reveal a putative neuromodulatory pathway critical for swarming behavior in C. elegans. ### Competing Interest Statement The authors have declared no competing interest. Wellcome Trust/DBT India Alliance, https://ror.org/04reqzt68, IA/S/19/2/504649 ANRF-POWER

Next, characterisation of a swarming phenotype in calsyntenin mutants of worms. Navneet spearheaded this cool work, helped by Nisha, Sharveri and Dimple. Thanks also to Egemen and Askin for help. Thanks to colleagues, funding ANRF, India Alliance and IISc #CNSIISc 7/n
www.biorxiv.org/content/10.1...

07.07.2025 03:41 πŸ‘ 5 πŸ” 1 πŸ’¬ 2 πŸ“Œ 0
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🚨Looking for #grant opportunities in #neuroscience? Here are all the current open calls at IBRO. Don't wait too long to apply - the deadlines are approaching!
buff.ly/17r6uS3

#IBROinAsiaPacific #IBROinUSCanada #IBROinAfrica #IBROinLatAm #IBROinEurope

18.06.2025 08:01 πŸ‘ 2 πŸ” 2 πŸ’¬ 0 πŸ“Œ 0
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FLP-15 modulates the amplitude of body bends during locomotion in Caenorhabditis elegans Locomotion is essential for executing most behaviours. In Caenorhabditis elegans. Efficient locomotion is exhibited as a result of the coordination of excitatory and inhibitory signals from the nervou...

This is a follow-up if Umer's preprint on the role of FLP-15 in foraging. Umer, Sharanya, Siju and Namra study the role of FLP-15 in maintaining normal body-bends in C. elegans. funding thanks DBT, India Alliance, ANRF and IISc Bangalore
#CNSIISc. 6/n www.biorxiv.org/content/10.1...

14.05.2025 13:11 πŸ‘ 5 πŸ” 1 πŸ’¬ 1 πŸ“Œ 0

FLP-15 functions through the GPCR NPR-3 to regulate local and global search behaviours in Caenorhabditis elegans https://www.biorxiv.org/content/10.1101/2025.05.02.651881v1

08.05.2025 19:15 πŸ‘ 3 πŸ” 2 πŸ’¬ 0 πŸ“Œ 0

Happy to see a version of this out here. Many thanks to our collaborators @monikakscholz.bsky.social, Jun and Yun. The initial idea for this work was Ashwani's. Thanks to many colleagues, funding thanks DBTIndia, India Alliance, ANRF and IISc, Bangalore #CNSIISc. 5/n

10.05.2025 03:32 πŸ‘ 2 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0
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FLP-15 functions through the GPCR NPR-3 to regulate local and global search behaviours in Caenorhabditis elegans Foraging is essential for sustenance and well-being of all organisms. The transition from well-fed to food-deprived conditions in C. elegans triggers a localized exploration of the environment charact...

The next one is Umer's work on the study of foraging behaviour in worms. He found that the neuropeptide FLP-15 was required for local and global search beaviours. Umer was helped by Siju, Sharanya and Namra. 4/n www.biorxiv.org/content/10.1...

10.05.2025 03:32 πŸ‘ 5 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0
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Make #IBRO2027 a dynamic & inclusive global gathering by proposing candidates to join the Scientific Program Committee! Learn more & help us shape an innovative, inclusive & high-impact program: ibro.org/ibro-2027-wo...

Deadline: 16 May 2025
#conference #neuroscience @thebalelab.bsky.social

15.04.2025 09:42 πŸ‘ 14 πŸ” 9 πŸ’¬ 0 πŸ“Œ 2
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Ageing speeds up at high altitudes, unless you’re native Tibetan. Their DNA methylation patterns adapt immune function and oxygen use to extreme conditions. A beautiful example of epigenetic resilience.

06.05.2025 16:15 πŸ‘ 51 πŸ” 13 πŸ’¬ 3 πŸ“Œ 3
Postdoctoral Research Associate, Biology About the Opportunity Job Summary The Apfeld Lab at Northeastern University is seeking a postdoctoral researcher to investigate how genes work together to determine the maximum lifespan of the nematod...

Love worms, molecular genetics, and big questions? We’re hiring a postdoc to build a CRISPRa toolkit to identify new aging mechanisms in C. elegans.

Email or DM me to find out more. Please share & repost!

29.04.2025 20:54 πŸ‘ 39 πŸ” 41 πŸ’¬ 1 πŸ“Œ 2

Yet another horrible, wasteful decision…

23.04.2025 08:25 πŸ‘ 53 πŸ” 14 πŸ’¬ 3 πŸ“Œ 1
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#NewComicAlert!
We are back with another inspiring comic with Tinkle Magazine featuring cognitive and behavioural neuroscientist Dr Abhilasha Joshi! 🧠 πŸ€

Happy reading!
Download your free copy here: bit.ly/ncbsxtinklec...

@rhythmicspikes.bsky.social

#sciencecomics #womenscientists

04.04.2025 12:33 πŸ‘ 9 πŸ” 6 πŸ’¬ 0 πŸ“Œ 1

1/11 Though it's personal, I’m sharing this analogy if it helps others: In the last few weeks, I’ve been thinking a lot about my past journey with cancer.

Years ago, I found out in the worst way. My doctor accidentally released the biopsy results to my online patient portal.

🧡 Thread

09.02.2025 14:55 πŸ‘ 108 πŸ” 25 πŸ’¬ 5 πŸ“Œ 14

Mai Hoon Na, has a little bit of everything and is not nuanced. Rangeela and Rang de Basanti are others I have suggested people watch as a first movie.

14.03.2025 13:27 πŸ‘ 2 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0