Our most recent work on the “function and evolution” of #nuclear-speckles is now online at Cell @cp-cell.bsky.social
doi.org/10.1016/j.ce...
Read the thread👇 for the highlights of our findings.
How to keep in step when your (protein) partner speeds up…
Here we investigated the adaptive remodeling of a protein-protein interaction surface essential for telomere protection.
Congrats to whole team!
www.science.org/doi/10.1126/...
Excited to share our new preprint in collaboration with Ahmet Yildiz's lab. Check out how our team uncovers a novel binding footprint and motor regulation mechanism for MAP9 Congrats to Burak Cetin and @aryantaheri.bsky.social
www.biorxiv.org/content/10.1...
📢 Our Dept. of Systems Biology at Columbia University has an open tenure-track Assistant Professor position in the broad area of quantitative biology. Come join our awesome department in NYC! Please circulate.
apply.interfolio.com/177622
Suggested deadline: 12/15/2025.
@columbiasysbio.bsky.social
Our paper in Science is out! @souravagrawal.bsky.social, @rlynn.bsky.social, @susvirkar.bsky.social, and the rest of the team show human RPA is a telomerase processivity factor essential for telomere maintenance. This reshapes our thinking about telomerase regulation. www.science.org/doi/10.1126/...
Great work from our future neighbor!
Check out this extremely cool work by @fueyoraquel.bsky.social on how human specific ERVs contribute to early development!
Today in @nature.com , we highlight how a cousin of CRISPR-Cas10, mCpol, establishes an evolutionary trap in anti-phage immune systems.
Check out @erinedoherty.bsky.social and my work from @doudna-lab.bsky.social lab here:
www.nature.com/articles/s41...
Thank you Flora!
🧪 We’re hiring at all levels! If you're interested in transposons, genome biology, cryoEM, RNA, chromatin, or genome engineering—let’s talk! Particularly interested in enthusiastic technicians and postdoctoral fellows!
Email me and check out our lab website to learn more! #TeamScience #WeAreHiring
Grateful for many other supporters in this journey: the entire @leadingedgeprogram.bsky.social community, @bwfund.bsky.social, @damonrunyon.org, and a number of mentors within and outside @ucberkeleyofficial.bsky.social. It's been a joy ride!
Huge thanks to my incredible mentors—Eva @nogaleslab.bsky.social, Kathy Collins and members of these two labs for their support and generosity during my postdoc. I've learned so much from you.
Extremely excited to share that I’m joining Columbia University @columbiauniversity.bsky.social as an Assistant Professor!
We will explore how the mobile genome works—how transposons shape us, our DNA and how they can be harnessed to build useful technologies. #NewPI #RNAsky #TEsky
thawanilab.org
Congrats Luuk!
RNA N-glycosylation enables immune evasion and homeostatic efferocytosis by chemically caging acp3U. Excited to report this work lead by Vinnie @vinnieviruses.bsky.social and in collaboration with @vijayrathinam.bsky.social in @nature.com www.nature.com/articles/s41...
Looking forward to this new installment of the Woods Hole Mobile DNA Meeting! Fantastic program, laid-back atmosphere, and gorgeous setting at the Marine Biological Laboratory ⛵️🪼🐋
Abstract submission closes Aug 7 but registration after that date is possible. www.eventsquid.com/event.cfm?ev...
Many proteins bind RNA, yet we still don’t know what RNAs most bind because methods map one RBP at a time. In @cp-cell.bsky.social, with the Jovanovic lab, we describe SPIDR – a method for mapping the RNA binding sites of dozens of RBPs in a single experiment. www.sciencedirect.com/science/arti...
#TEsky Structural basis for the evolution of a domesticated group II intron–like reverse transcriptase to function in host cell DNA repair doi.org/10.1073/pnas...
Ready to lead pioneering research that bridges systems-level investigations of biological systems to molecular mechanism? The EMBL Molecular Systems Biology Unit in Heidelberg is hiring a Group Leader!
🦠🧍♀️From bacterial to human immunity.
We report in @science.org the discovery of a human homolog of SIR2 antiphage proteins that participates in the TLR pathway of animal innate immunity.
Co-led wt @enzopoirier.bsky.social by D. Bonhomme and @hugovaysset.bsky.social
www.science.org/doi/10.1126/...
The Xue lab at UC Irvine is looking for a staff scientist to support our work investigating how microbes interact and evolve in the gut microbiome! Open to a wide range of previous experience levels, see ad for more.
recruit.ap.uci.edu/JPF09601
Congrats @kedmonds.bsky.social @maxewilkinson.bsky.social et al on your beautiful work being out!
We wrote a review on Transposable Elements (TEs) and almost all aspects of TE silencing and their roles in biological processes & disease.
www.nature.com/articles/s41...
Deeply touched and honored by the Universidad Autónoma de Madrid, my alma mater, (@uam.es) making me Doctor Honoris Causa. Thank you to the Department of Physical Chemistry for nominating me for this recognition. It was a memorable day for me and my family👩🎓
Like a dream, my name next to that of @isabelallende.com, and to be recognized by Universidad Internacional Menéndez Pelayo UIMP. Soon after, Irene Vallejo @irenevalmore.bsky.social will receive the same honor. I feel proud to be linked to these truly inspiring, talented women! Thank you UIMP!
Structures of vertebrate R2 retrotransposon complexes during target-primed reverse transcription and after second-strand nicking pubmed.ncbi.nlm.nih.gov/40540573/ #cryoEM
It was a joy ride to be working on this project alongside Anthony Rodríguez-Vargas, @nozhathassan.bsky.social, Briana Van Treeck and my fearless mentors Kathy and @nogaleslab.bsky.social!
And thanks for the very important support from the NIH, @hhmi.org and @damonrunyon.org for this work! (5/n)
Besides the initiation of insertion, we could also determine the #cryoEM structure of another biochemical intermediate where the first strand synthesis and second strand nicking has completed (4/n)
The expanded zinc finger array within these new R2s covers the upstream target site entirely to enable more precise junction formation (3/n)
