Lena Spieth

Huge thanks to all co-authors and collaborators, especially Ruoqing Feng, Stefan Berghoff, Lu Liu, and Jonas Franz.

Single-cell spatial transcriptomic profiling defines a pathogenic inflammatory niche in chronic active multiple sclerosis lesions Compartmentalized inflammation is a key driver of multiple sclerosis (MS) progression, but the mechanisms sustaining its persistence remain unclear. A…

Our new paper reveals that chronic active MS lesions feature CD8⁺ T cell niches with lipid-laden, inflamed microglia. IFN-γ drives cholesterol buildup, linking dysregulated lipid metabolism to inflammation and meurodeg.
Check it out @cp-immunity.bsky.social

www.sciencedirect.com/science/arti...

Adaptor protein complex 2 (AP2) participates in biogenesis and homeostasis of myelin sheaths in the central nervous system Myelination of CNS axons requires oligodendrocytes to undergo extensive morphological changes by producing large amounts of myelin membrane with defined protein composition and structure. The formatio...

If you're interested in trafficking of #myelin constituents in #oligodendrocytes, and of course you are, you may want to check out our new preprint. It's very nice PhD work by @sophiesiems.bsky.social, and we're grateful to all who contributed!

www.biorxiv.org/content/10.1...

Congratulations @sophiesiems.bsky.social and @almeidalab.bsky.social 🎉🍰🍾🥨

How does APOE change your risk of developing Alzheimer's disease? At least partially by changing the function of immune cells in your brain 🧠🧬

New paper out in @natcomms.nature.com today: www.nature.com/articles/s41...

@ukdri.ac.uk @kingsioppn.bsky.social @imperialbrains.bsky.social

Oligodendrocytes in Alzheimer’s disease pathophysiology - Nature Neuroscience Emerging evidence highlights the dual role of oligodendrocytes in Alzheimer’s disease, both providing protective mechanisms against the pathology and contributing to its progression.

A Review on #oligodendrocytes in Alzheimer’s disease pathophysiology from Shreeya Kedia & Mikael Simons 🧪🧠

www.nature.com/articles/s41...

5FAD transgene parentage influences plaque burden. 🐭 Congratulations @aosasmita.bsky.social, @taisiianazarenko.bsky.social @constanze depp and @Klaus-Armin Nave. Happy to have contributed a little.

White matter aging and its impact on brain function Aging leads to a decrease in white matter volume and damage to myelinated axons, contributing to neurodegeneration. Myelin breakdown can trigger inflammation, creating a vicious cycle that causes further damage. Understanding these changes is key to preventing age-related neurodegenerative disease.

How does aging affect the white matter and what are the consequences for brain function and neurodegenerative disease? Thankful to see this review with Mika Simons now published in a fascinating collection on the science of brain aging @cp-neuron.bsky.social
www.cell.com/neuron/fullt...

Are oligodendrocytes bystanders or drivers of Parkinson’s disease pathology? The major pathological feature of Parkinson ‘s disease (PD), the second most common neurodegenerative disease and most common movement disorder, is the predominant degeneration of dopaminergic neurons...

Did you ever wonder about the role of oligodendrocytes in Parkinson's disease? Check out our new unsolved mysteries article in collaboration with the Burbulla lab! It is quite certain that a lot of work moves in this direction.

journals.plos.org/plosbiology/...

Homeostatic microglia initially seed and activated microglia later reshape amyloid plaques in Alzheimer’s Disease - Nature Communications The role of microglia in Alzheimer’s disease is debated. This paper shows that homeostatic microglia seed amyloid plaques in early disease stages and activated microglia compact plaques at later stage...

Homeostatic microglia initially seed and activated microglia later reshape amyloid plaques in Alzheimer’s Disease

This further adds to the mounting evidence that microglia are perhaps much better at Aβ plaque formation than plaque clearance. What a fantastic study 🤩

Fixation time affects RNA scope results in human FFPE brains. Check out this paper from the Jäkel lab!

Thanks for starting this, would like to join, could you add me please ?

Hi Anna, I would like to join, could you add me please ?

Thanks for starting this, could you add me please ?