Matheus Fragas

The Neurolipid Atlas: a lipidomics resource for neurodegenerative diseases - Nature Metabolism The authors introduce the Neurolipid Atlas, a dynamic resource for the community to gain insight into lipid alterations in neurodegenerative disease, and they leverage the platform to show how cholest...

The Neurolipid Atlas: a lipidomics resource for neurodegenerative diseases

www.nature.com/articles/s42...

Plasma proteomics links brain and immune system aging with healthspan and longevity - Nature Medicine In a large-scale proteomic study of biological aging of 11 organs from 44,498 individuals in the UK Biobank, the biological ages of the brain and immune system emerged as strong predictors of healthsp...

Plasma proteomics links brain and immune system aging with healthspan and longevity
www.nature.com/articles/s41...

Understanding monocyte-driven neuroinflammation in Alzheimer’s disease using human cortical organoid microphysiological systems Monocytes from Alzheimer’s disease patients induce disease phenotypes in human cortical organoid microphysiological systems.

Understanding monocyte-driven neuroinflammation in Alzheimer’s disease using human cortical organoid microphysiological systems
www.science.org/doi/10.1126/...

Early intervention anti-Aβ immunotherapy attenuates microglial activation without inducing exhaustion at residual plaques - Molecular Neurodegeneration Anti-amyloid β-peptide (Aβ) immunotherapy was developed to reduce amyloid plaque pathology and slow cognitive decline during progression of Alzheimer’s disease. Efficient amyloid clearance has been pr...

Early intervention anti-Aβ immunotherapy attenuates microglial activation without inducing exhaustion at residual plaques
molecularneurodegeneration.biomedcentral.com/articles/10....

NLRP3-mediated glutaminolysis controls microglial phagocytosis to promote Alzheimer’s disease progression How NLRP3 impacts Alzheimer’s disease (AD) is unclear. McManus et al. find that NLRP3 is located at mitochondria where it regulates microglial metabolism. Depletion or chronic pharmacological inhibiti...

I am thrilled to share our latest article that has been published in @cp-immunity.bsky.social. We describe a new role for NLRP3 outside of its #inflammasome complex, where it can regulate microglial #metabolism & key metabolites that affect the epigenetic landscape(1)
www.cell.com/immunity/ful...

I think the field needs to reconsider the widespread concept that microglia are The most important factor controlling synaptic pruning.🧠🧪

We offered our Perspective on whether they are hunters or gatherers of synaptic debris here
www.nature.com/articles/s41...

Typical development of synaptic and neuronal properties can proceed without microglia in the cortex and thalamus - Nature Neuroscience Microglia are proposed to have a role in brain development through synaptic engulfment and paracrine signaling. O’Keeffe et al. show that certain neurodevelopmental processes attributed to microglia c...

Typical development of synaptic and neuronal properties can proceed without microglia in the cortex and thalamus
www.nature.com/articles/s41...

In vivo hyperphosphorylation of tau is associated with synaptic loss and behavioral abnormalities in the absence of tau seeds - Nature Neuroscience Mice expressing humanized mutant tau exhibit synaptic loss and behavioral abnormalities in the absence of abnormal tau conformers, suggesting that hyperphosphorylated tau can be pathological, at least...

In vivo hyperphosphorylation of tau is associated with synaptic loss and behavioral abnormalities in the absence of tau seeds
www.nature.com/articles/s41...

Microglia internalize tau monomers and fibrils using distinct receptors but similar mechanisms
alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

Mitochondrial fatty acid oxidation drives senescence Nuclear DNA damage activates fatty acid–fueled mitochondrial energy metabolism to induce cellular senescence, a hallmark of aging.

Mitochondrial fatty acid oxidation drives senescence
www.science.org/doi/10.1126/...

A neurodegenerative cellular stress response linked to dark microglia and toxic lipid secretion
www.cell.com/neuron/abstr...

Extrasinusoidal macrophages are a distinct subset of immunologically active dural macrophages Extrasinusoidal dural macrophages are a distinct subset of immunologically active central nervous system–associated macrophages.

Extrasinusoidal macrophages are a distinct subset of immunologically active dural macrophages
www.science.org/doi/10.1126/...

Immune mechanisms and shared immune targets in neurodegenerative diseases - Nature Reviews Neurology The immune system plays a major part in neurodegenerative diseases. In this Review, Weiner considers the contributions of several components of the immune system in multiple neurodegenerative diseases...

Immune mechanisms and shared immune targets in neurodegenerative diseases.
doi.org/10.1038/s415...

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Astrocytic mitochondrial transfer to brain endothelial cells and pericytes in vivo increases with aging
journals.sagepub.com/doi/10.1177/...

Homeostatic microglia initially seed and activated microglia later reshape amyloid plaques in Alzheimer’s Disease - Nature Communications The role of microglia in Alzheimer’s disease is debated. This paper shows that homeostatic microglia seed amyloid plaques in early disease stages and activated microglia compact plaques at later stage...

Homeostatic microglia initially seed and activated microglia later reshape amyloid plaques in Alzheimer’s Disease
www.nature.com/articles/s41...

Microglia degrade Alzheimer’s amyloid-beta deposits extracellularly via digestive exophagy Jacquet et al. shows that microglia use digestive exophagy to engage large Aβ deposits that cannot be phagocytosed, forming acidic extracellular compartments on the aggregates into which lysosomal enzymes are exocytosed. The PI3K-AKT pathway modulates this process. Microglia also exocytose intralysosomal undigested fibrillar Aβ toward extracellular aggregates, potentially contributing to plaque growth.

Microglia degrade Alzheimer’s amyloid-beta deposits extracellularly via digestive exophagy

www.cell.com/cell-reports...

Neuroinflammation in Alzheimer disease - Nature Reviews Immunology This Review provides an in-depth examination of how inflammation contributes to neurodegeneration in Alzheimer disease. The authors explore the impact of extrinsic factors, such as brain trauma, diet ...

Neuroinflammation in Alzheimer disease
www.nature.com/articles/s41...

Microglia cannibalism and efferocytosis leads to shorter lifespans of developmental microglia The microglia population is considered long lived. This study demonstrates that individual embryonic microglia die within 3 days after clearing neural debris and are cannibalized by existing microglia...

Microglia cannibalism and efferocytosis leads to shorter lifespans of developmental microglia
journals.plos.org/plosbiology/...

BTK regulates microglial function and neuroinflammation in human stem cell models and mouse models of multiple sclerosis - Nature Communications Bruton’s tyrosine kinase (BTK) is expressed in immune cells and microglia, where its role remains poorly understood. Here, the authors show that BTK modulates microglial neuroinflammatory pathways rel...

BTK regulates microglial function and neuroinflammation in human stem cell models and mouse models of multiple sclerosis
www.nature.com/articles/s41...

Meningeal neutrophil immune signaling influences behavioral adaptation following threat
www.cell.com/neuron/abstr...

Tau filaments are tethered within brain extracellular vesicles in Alzheimer’s disease
www.nature.com/articles/s41...

APOE from astrocytes restores Alzheimer’s Aβ-pathology and DAM-like responses in APOE deficient microglia
www.embopress.org/doi/full/10....