Megan Chastney

The dynamic tumor extracellular matrix: Biophysical cues, cellular crosstalk, and disease progression The interplay between diverse cell types and their extracellular matrix (ECM) is fundamental for multicellular life. The ECM is a complex meshwork of …

Review alert! Our new review titled 'The dynamic tumor extracellular matrix: Biophysical cues, cellular crosstalk, and disease progression,' is now online!

Congrats to all the authors! Link: tinyurl.com/bdh6zzzp

CELL MIGRATION LAB We study cell migration in health and disease

🚨 We are hiring TWO postdocs to join the Cell Migration Lab (cellmig.org) 🇫🇮 as part of the new Centre of Excellence in Immune–Endothelial Interfaces (IMMENs).
Join us to decode immune regulation & develop next-gen imaging tools! 🧪🔬
Details in thread 🧵👇
#ScienceSky #Postdoc #AcademicJobs Please RT🫶

Postdocs wanted - Please spread the word! We are looking for one bioinformatician and 1-2 cell biologists with different expertise! See the job ad below for more information and links to the job descriptions!

Come and work with us, We are looking for a new group leader at Turku Bioscience @turkubioscience.bsky.social.
Åbo Akademi University invites applications for a fixed term position as Head of Research in Bioscience (Principle Investigator).

abo.rekrytointi.com/paikat/?o=A_...

EPLINα controls integrin recycling from Rab21 endosomes to drive breast cancer cell migration Epithelial protein lost in neoplasm (EPLIN), an actin-binding protein, has been described as both a tumor promoter and tumor suppressor in different c…

Very happy to share Niklas Jäntti's PhD work on EPLIN /LIMA1 isoforms (α/β) in breast cancer (spoiler: both have opposing roles in integrin traffic, cell migration & clinical outcome). This might explain why EPLIN sometimes has been reported as pro- and sometimes as anti-tumorigenic: bit.ly/3Iwjtau

We are very proud to announce @johannaivaska.bsky.social as the recipient of the Biennial Finnish Science Award, given by the Finnish Ministry of Education & Culture. Johanna was described as a distinguished researcher with pioneering work in cell biology. Warmest congrats from all of us, boss!

New paper from @ivaskalab.bsky.social out now! 🍾 Watch how cancer cell adhesion dynamics are disrupted by inhibiting the phosphatase Shp2 - key to integrin β1 phosphorylation. Blocking Shp2 impairs adhesion and reduces invasion potential. 🎥👇 Read more at: www.nature.com/articles/s41...

Congratulations to Pat Caswell (@integrintraffic.bsky.social) & Alexandra Naba (@matrisome.bsky.social) who will be vice-chairs of the 2027 Fibronectin, Integrins & Related Molecules GRC and chairs of the 2029 meeting!

Adhesion-derived condensates control component availability to regulate adhesion dynamics Integrin adhesion complexes mediate cell-extracellular matrix (ECM) interactions and undergo dynamic remodelling to regulate cell adhesion and migration. Here, we demonstrate that tensin 1 (TNS1), a m...

Happy to share our Tensin 1 phase separation project is now on bioRxiv.
www.biorxiv.org/content/10.1...

This wouldn't be possible without
@johannaivaska.bsky.social
@ivaskalab.bsky.social
#VattulainenLab
#MSCA by @ec.europa.eu
@turkubioscience.bsky.social
@inflames-flagship.bsky.social

Macrophages promote collagen deposition through circadian regulation of fibroblasts Collagen deposition in fibroblasts, the primary collagen-producing cells, is regulated by both macrophages and the circadian rhythm, although how these regulatory processes interact with one another i...

Our lab's #1st manuscript from our #1st #PhD Katie is on #bioRxiv! Check it out 👇🏻

#macrophage regulation of fibroblast #collagen #circadian rhythm. #ImmunoECMatrix w/ @profandrewmac.bsky.social @tracyh9494.bsky.social @mcrcellmatrix.bsky.social @mcf-uom.bsky.social

www.biorxiv.org/content/10.1...

Bicentenary PhD Studentships and Fellowships | The University of Manchester Learn more about the Bicentenary PhD Studentships and Fellowships launched as part of The University of Manchester's 200th year.

Maybe of interest to the talented ECR network of @themeshwork.bsky.social ? www.manchester.ac.uk/research/bic...

#ECMatrix researchers, please share:

Just under 2 weeks until the abstract deadline (21st Feb) for the 3-day Matrix Nexus meeting in Freiburg. Topics include #cancer #collagens #proteoglycans #proteases #tissueengineering & a session dedicated to #ECRs!

www.matrixbiologie.de/annual-meeti...

Photo: Visit Seili

🚀 SAVE THE DATE! The 4th BioImage Informatics Finland (BIIF) Symposium is happening 📅 May 22-23, 2025!

Join researchers & facility experts to discuss the latest in image analysis & data management.

📍Seili, Turku Archipelago 🇫🇮

Stay tuned for program & registration #BIIF2025

Photo: Visit Seili

I put together a small guide on how to get started with Fiji. Please distribute to anyone who might benefit form this! zenodo.org/records/1477... #imageanalysis #fiji #imagej #training

The deadline for abstract submission has now been extended until the 10th Feb!

Research Associate - Mechanisms Associated with Extracellular Matrix Assembly and Stability at The University of Manchester Apply for the Research Associate - Mechanisms Associated with Extracellular Matrix Assembly and Stability role on jobs.ac.uk, the top job board for academic positions in higher education. View details...

We are hiring!!

How do basement membranes become stable structures during tissue growth? How can we measure turnover and dynamics?

Come and join our team to help us answer these questions!

@mcrcellmatrix.bsky.social
@stramerlab.bsky.social

More info 👇

www.jobs.ac.uk/job/DLN927/r...

A reminder to colleagues interested in Cell-Matrix adhesion & anything ECM related that registration is now open for the Fibronectin, Integrins & related molecules Gordon Research Conference. Incredible list speakers! incredible location! it will 🔥 🔥 🔥 Please join us! www.grc.org/fibronectin-...

For early career researchers interested in the Fibronectin, Integrins and Related Molecules GRS/GRC this May, don’t forget to sign up! The deadline for submitting an abstract to be considered for an oral presentation for the GRS is less than a week away! Register here: www.grc.org/fibronectin-...

Endocytic recycling is central to circadian collagen fibrillogenesis and disrupted in fibrosis Secretion and fibrillogenesis of collagen-I are separately controlled molecular pathways in the fibroblast, where surprisingly endocytic recycling is required for fibril formation and is increased in ...

Very glad to see this study finally out (and mentioned on bsky already!)- it's been a huge #collaboration across different groups🙏🏻

Fibroblasts recycles (in a #circadian manner) #collagen to make new fibrils, which is enhanced in #fibrosis.

doi.org/10.7554/eLif...
@elife.bsky.social

📣 Everything you always wanted to know about the #ECM (but were afraid to ask). Join me at @themeshwork.bsky.social seminar series in December to learn about the latest developments of the #Matrisome project @matrisome.bsky.social! Sign up here forms.gle/W3QFUheh9hf5... and help us spread the word!

Signaling downstream of tumor-stroma interaction regulates mucinous colorectal adenocarcinoma apicobasal polarity Mucinous colorectal carcinoma (MUC CRC) dissemination into the tumor stroma and metastasis to multiple organs, including the peritoneum, is associated with poor prognosis. Disseminating MUC CRCs exhib...

Here is the most recent preprint from our most recent PhD graduate, Dr Nicolas Pasquier. Orientation of mucinous CRC apicobasal polarity is regulated by tumor-stroma interactions. This work was a collaboration with the Jaulin lab at the Gustave Roussy Institute.
www.biorxiv.org/content/10.1...

Delighted to share our latest paper:

"The glomerular circadian clock temporally regulates basement membrane dynamics and the podocyte glucocorticoid response"

Expertly led by Rebecca Preston & in collaboration with clock superstar Qing Jun Meng

pubmed.ncbi.nlm.nih.gov/39515644/

Key findings 👇👇

Ivaska cell adhesion and cancer Lab Integrins, matrix, motility and mechanotransduction in cancer

Introductory post on 🦋! We're a research group headed by Prof. Johanna Ivaska interested in understanding how integrins contribute to every step of cancer progression. We're located at the Turku Bioscience Center in Turku, Finland! Find out more about us and our interests here: ivaskalab.utu.fi