Hsieh-Wilson Lab @ Caltech

Cracking the code to O-GlcNAcylation networks - Nature Chemical Biology Understanding protein glycosylation is essential to decode complex cellular networks. A systems-level approach that networks substrate and interacting proteins of O-GlcNAc transferase, the sole enzyme...

We're excited to learn that our NOTISE method of networking OGT interactors and substrates is the subject of a News & Views article, "Cracking the code to O-GlcNAcylation networks"! Thanks to the authors for the nice feature. Find the article here: doi.org/10.1038/s415... #NOTISEme #glycotime

It was #glycotime at last week's organic chemistry seminar! Prof. Charlie Fehl gave a great talk about his lab's work studying aberrant glycosylation in hyperglycemic disease. Very cool to see the tools they've developed.

Functional analysis of O-GlcNAcylation by networking of OGT interactors and substrates - Nature Chemical Biology Functional studies of O-GlcNAcylation have often focused on individual modifications. Now, a systems-level approach has identified simultaneous O-GlcNAcylation events that coordinate cellular activiti...

We integrated experimental and computational approaches to generate a systems-level view of a key post-translational modification, O-GlcNAc. In vivo studies across tissues reveal shared and tissue-specific functions. Congrats to Matt, John, Yao, and the whole team! #NOTISEme bit.ly/3ZgCOBM

Functional analysis of O-GlcNAcylation by networking of OGT interactors and substrates - Nature Chemical Biology Functional studies of O-GlcNAcylation have often focused on individual modifications. Now, a systems-level approach has identified simultaneous O-GlcNAcylation events that coordinate cellular activiti...

Functional studies of O-GlcNAcylation have often focused on individual modifications. Now, a systems-level approach has identified simultaneous O-GlcNAcylation events that coordinate cellular activities and tissue-specific functions #glycotime

www.nature.com/articles/s41...