Dr. Hab Sophie Sacquin-Mora's Avatar

Dr. Hab Sophie Sacquin-Mora

@sacquin-mo

CNRS research director modelling #Proteins. Lab. Biochimie Théorique UMR8266, IBPC #WomanInSTEM Website: http://www-lbt.ibpc.fr/people/sacquin Popularization blog (in french): https://topoftheprots.com/

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Latest posts by Dr. Hab Sophie Sacquin-Mora @sacquin-mo

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a man and a woman standing next to each other with the words on avait dit pas la science Alt: Bertand Usclat en agriculteur en biodynamie fracasse un ordinateur en hurlant "On avait dit pas la science"

Cf. le magnifique épisode de Broute sur le sujet.

09.03.2026 20:16 👍 2 🔁 0 💬 1 📌 0
Original (left) and corrected (right) Fig. 4a in the paper https://www.nature.com/articles/s41586-026-10305-0 showing the chemical structures of amino acids (only the right one) the left figure is just an embarrassment

Original (left) and corrected (right) Fig. 4a in the paper https://www.nature.com/articles/s41586-026-10305-0 showing the chemical structures of amino acids (only the right one) the left figure is just an embarrassment

I wonder... 🤔🤔🧪 #chemsky

a) what program did the authors use to make the original (left) figure in the paper? Wild guess, ChatGPT

b) how such high school science level of disgrace pass peer review in @nature.com?

Note this was Fig.4.a NOT in SI

www.nature.com/articles/s41...

06.03.2026 10:44 👍 41 🔁 21 💬 15 📌 2

L'évènement #ReCombinaisons est de retour à @pasteur.fr en 2026 avec un programme alléchant !
(On y retrouvera notamment @jeanneadebats.bsky.social et @audreypleynet.bsky.social !)

05.03.2026 13:44 👍 5 🔁 2 💬 0 📌 0
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🟣 In the framework of the #InternationalWomensDay #8March, we highlight the talented women involved in our MultiXscale CoE.

We kick off with:
Céline Merlet, Researcher in MultiXscale
CNRS - U. de Toulouse (France)

#VoicesOfMultiXscale: Women Driving Innovation

#WomenAtMultiXscaleCoE

05.03.2026 11:12 👍 1 🔁 2 💬 0 📌 0
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Chances are you have not heard her name, but Marcelle Lapicque may have been the first Black woman neuroscientist in Europe.

By @avaskham.bsky.social, @rebeccasky.bsky.social

#neuroskyence

www.thetransmitter.org/history-of-n...

24.02.2026 17:13 👍 35 🔁 23 💬 0 📌 2
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Des p’tits trous partout : les perforines, poinçonneuses de la cellule Dans le vivant, la membrane lipidique est la première garante de l’intégrité des cellules, ce qui en fait également une cible de choix pour les pathogènes. Elle peut notamment être visée par …

J'avais dit qu'en 2026, #TOTProts serait au repos, mais en fait non. Et donc aujourd'hui on va parler de perforines (la vérité, regardez-moi la beauté de ces assemblages !)
#Vulgarisation #FunScience
topoftheprots.com/2026/02/23/d...

23.02.2026 10:08 👍 4 🔁 3 💬 0 📌 0
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Equity, Diversity and Inclusion: Four women whose pioneering contributions to science have been largely overlooked Ethel Browne Harvey, Hilde Pröscholdt Mangold, Ida Henrietta Hyde and Marthe Gautier all made important contributions to developmental biology, but their names are largely absent from histories of sci...

Equity, Diversity and Inclusion: Four women whose pioneering contributions to science have been largely overlooked @elife.bsky.social #womeninSTEM

elifesciences.org/articles/110...

17.02.2026 07:17 👍 11 🔁 5 💬 0 📌 0
My linocut portrait of Marie Maynard Daly in purples (she’s a young smiling Black woman, wearing earrings, a necklace and a dress, looking at the viewer over her shoulder). Above her to the right is an anatomical heart with a blowout diagram in a circle of a clogged artery and the cholesterol molecule all in red. Next to her on the left in blue are the molecules of the bases which make up DNA and a diagram of a human cell.

My linocut portrait of Marie Maynard Daly in purples (she’s a young smiling Black woman, wearing earrings, a necklace and a dress, looking at the viewer over her shoulder). Above her to the right is an anatomical heart with a blowout diagram in a circle of a clogged artery and the cholesterol molecule all in red. Next to her on the left in blue are the molecules of the bases which make up DNA and a diagram of a human cell.

#BlackHistoryMonth is a great time to celebrate #biochemist Marie Maynard Daly (1921-2003), 1st Black woman to earn a PhD in #chemistry in the US! 🧪🐡👩🏿‍🔬 #histsci She made important research contributions to our understanding of the biochemisty of the cell nucleus & cardiovascular issues & the 🧵

15.02.2026 12:55 👍 133 🔁 46 💬 4 📌 2
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Elodie Arnould - La Scala Paris Dans ce 3ᵉ spectacle, Elodie fait le bilan : elle regarde ce dont elle a vraiment hérité… et ce qu’elle refuse de transmettre. Entre famille et vie de couple, elle...

Hier soir, j'ai vu le spectacle d'Élodie Arnould, ça faisait longtemps que j'avais pas ri de si non cœur. Vraiment ça fait du bien de voir que l'humour, c'est pas que des mecs blancs problématiques.

lascala-paris.fr/programmatio...

13.02.2026 06:52 👍 11 🔁 2 💬 1 📌 0
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By 2028, all 4-character PDB IDs will be exhausted.

After that, all new entries will receive extended IDs: 12 characters total, formatted as pdb_ + 8 alphanumeric characters (pdb_1000axyz)

Test it from PDB Beta Archive

Read more: www.wwpdb.org/news/news?ye...

12.02.2026 11:32 👍 22 🔁 14 💬 0 📌 6

Thursday February 12th at 11h00 

ENS Chemistry Dpt, Salle R

24, Rue Lhomond, 75005 Paris 

Understanding biomolecular condensates using simulations at multiple resolutions

Dr. Alessandro Barducci 

Centre de Biologie Structurale, Université de Montpellier, CNRS, INSERM, 

Montpellier, France

10.02.2026 11:08 👍 3 🔁 2 💬 0 📌 0

Apply!!! @embl.org rocks!

10.02.2026 12:04 👍 6 🔁 4 💬 0 📌 0

PS, et pour la énième fois : arrêtez les IAgen pour votre communication institutionnelle.
(la vérité faut vous le dire comment ?)

08.02.2026 14:39 👍 9 🔁 1 💬 0 📌 0

Et donc, si j'en crois l'illu générée pas IA de l'ENS, on peut faire de la science en étant une femme, mais le brushing et le port du rouge à lèvre restent obligatoires (exception faite de la schtroumpfette, qui a le droit à un chignon)

08.02.2026 14:37 👍 13 🔁 1 💬 5 📌 1
Job advert for MD related research projects in the department of theoretical and computational biophysics @mpi-nat.bsky.social

Job advert for MD related research projects in the department of theoretical and computational biophysics @mpi-nat.bsky.social

🧐 You are a physicist or chemist who wants to reveal how life works at the molecular level?

🤓 You know how to combine computer power and theory to solve biological problems?

❤️ You just love doing science?

👉 Send us your application!
🔗 Current job adverts www.mpinat.mpg.de/grubmueller

06.02.2026 15:09 👍 6 🔁 3 💬 0 📌 0
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Gladys Mae West obituary: mathematician who pioneered GPS technology She made key contributions to US cold-war science despite facing huge barriers as a Black woman.

No joke: I got angry hate mail today for writing an obituary of a Black woman scientist—because the person felt she did didn’t deserve the recognition.

Which just makes me want to share it again: www.nature.com/articles/d41...

06.02.2026 09:09 👍 47158 🔁 19333 💬 1352 📌 795

No, DeepMind has not solved the protein folding problem.

#Alphafold predictions are valuable hypotheses and accelerate but do not replace experimental structure determination.

05.02.2026 08:49 👍 92 🔁 24 💬 2 📌 0

Franchement, je préfère mes cartes postales bidouillées à n'importe quelle illu en IA. Donc si vous avez un n° avec un article qui parle de protéines, ça peut se faire.

04.02.2026 08:43 👍 2 🔁 0 💬 0 📌 0
Carte postale vintage de la saint Valentin avec un couple de protéines dessus.

Carte postale vintage de la saint Valentin avec un couple de protéines dessus.

Février, c'est le mois des amoureux, et si vous déclariez votre flamme avec des protéines ? #TOTProts #FunScience #Vulgarisation #UnAnDeProtéines
topoftheprots.com/2023/02/20/q...

04.02.2026 08:30 👍 6 🔁 0 💬 1 📌 0
CECAM - Accessibility, Inclusivity and Visibility in Computational Chemistry

Excited to share the upcoming CECAM workshop: “Accessibility, Inclusivity & Visibility in Computational Chemistry”!

📅 Apr 22–24, 2026
📍 Lyon (hybrid)
💸 Free registratration: deadline Mar 31

Join us to discuss how to make #Compchem more inclusive & accessible. Contributed talks welcome!

03.02.2026 08:19 👍 6 🔁 3 💬 0 📌 0

DynaPIN: A Tool for Characterizing Dynamic Protein Interfaces https://www.biorxiv.org/content/10.64898/2026.01.28.702288v1

01.02.2026 04:47 👍 5 🔁 3 💬 0 📌 0
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Please share!!! I am looking for a postdoctoral researcher to join us. Focus will be on exciting collaborative projects on lipids and membrane biology, pushing the boundaries of in silico "reconstitutions". Previous experience with molecular dynamics simulations of biological systems a strong plus!

30.01.2026 09:49 👍 17 🔁 14 💬 0 📌 0

Et parmi les 72 femmes dont le nom sera bientôt inscrit sur la Tour Eiffel, deux grandes figures historiques de l'IBPC : Marianne Manago et Alberte Pullman ! 🎉

27.01.2026 09:44 👍 7 🔁 1 💬 0 📌 0
Vibrant color portrait of Jane S. Richardson, the visionary biophysicist and artist who revolutionized structural biology with her invention of ribbon diagrams. She gazes warmly at the camera with a bright, knowing smile that radiates quiet brilliance and decades of curiosity. Her silver-blonde hair woven with gentle waves. Large, elegant dangling earrings catch the light, and she wears a richly patterned brown blouse embroidered with intricate turquoise paisley motifs and delicate beadwork that echoes the molecular elegance she has spent her life depicting. Behind her floats a luminous, dreamlike backdrop of glowing molecular structures--interlocking hexagonal and ribbon-like forms in electric blues, teals, and greens--blending science and art in a single, living canvas.

Vibrant color portrait of Jane S. Richardson, the visionary biophysicist and artist who revolutionized structural biology with her invention of ribbon diagrams. She gazes warmly at the camera with a bright, knowing smile that radiates quiet brilliance and decades of curiosity. Her silver-blonde hair woven with gentle waves. Large, elegant dangling earrings catch the light, and she wears a richly patterned brown blouse embroidered with intricate turquoise paisley motifs and delicate beadwork that echoes the molecular elegance she has spent her life depicting. Behind her floats a luminous, dreamlike backdrop of glowing molecular structures--interlocking hexagonal and ribbon-like forms in electric blues, teals, and greens--blending science and art in a single, living canvas.

Hand-drawn and hand-colored (by Jane Richardson) scientific artwork known as a Richardson ribbon diagram (or “ribbon model”), one of the iconic visual inventions of Jane Richardson that transformed the way we see and understand protein structures. A graceful, three-dimensional tangle of protein backbone ribbons twists and spirals through space, rendered in soft pencil lines and luminous watercolor hues. Smooth golden-brown coils represent α-helices that curl like elegant ribbons, while broad teal-green arrows trace the flat, pleated strands of β-sheets slicing through the molecule with directional purpose. Thin, looping golden threads connect the secondary structures, creating a delicate, almost dance-like choreography of biology’s hidden architecture. The entire form is framed by a simple olive-green mat and dark border, giving the drawing the quiet dignity of both fine art and precise scientific illustration—a timeless bridge between molecular reality and human imagination.

Hand-drawn and hand-colored (by Jane Richardson) scientific artwork known as a Richardson ribbon diagram (or “ribbon model”), one of the iconic visual inventions of Jane Richardson that transformed the way we see and understand protein structures. A graceful, three-dimensional tangle of protein backbone ribbons twists and spirals through space, rendered in soft pencil lines and luminous watercolor hues. Smooth golden-brown coils represent α-helices that curl like elegant ribbons, while broad teal-green arrows trace the flat, pleated strands of β-sheets slicing through the molecule with directional purpose. Thin, looping golden threads connect the secondary structures, creating a delicate, almost dance-like choreography of biology’s hidden architecture. The entire form is framed by a simple olive-green mat and dark border, giving the drawing the quiet dignity of both fine art and precise scientific illustration—a timeless bridge between molecular reality and human imagination.

Jane Richardson was born #OTD in 1941

+ Developed the Richardson (ribbon) diagram to represent proteins' 3D structure (becoming a standard representation for protein structures)
+ MacArthur Fellow, 1985
+ Elected, Nat'l Academy of Sciences, 1991
+ President, Biophysical Society, 2012

#WomenInSTEM

26.01.2026 00:06 👍 266 🔁 93 💬 3 📌 7

We are happy to announce CAPRI Round 62, featuring a total of nine antigen/antibody targets.

Registration opens tomorrow, Jan 23rd.

The targets will be offered in two prediction periods, with prediction of the first five targets starting Feb 16th, and of the last four targets starting Mar 16th.

22.01.2026 17:24 👍 4 🔁 4 💬 1 📌 0

Have you ever heard that women have more chances than men of getting grants or positions in academia? Of course you have, and here are my personal views on this. With the shocking revelation that no, it is NOT TRUE ! (1/n)

13.01.2026 18:36 👍 115 🔁 77 💬 7 📌 6
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We've got ISSUES. Literally.

We scraped >100k special issues & over 1 million articles to bring you a PISS-poor paper. We quantify just how many excess papers are published by guest editors abusing special issues to boost their CVs. How bad is it & what can we do?

arxiv.org/abs/2601.07563

A 🧵 1/n

13.01.2026 08:24 👍 505 🔁 314 💬 17 📌 49
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Fresh news on de novo genes! Happy to present our latest work published in Nature communications: www.nature.com/articles/s41...

Keywords not in specific order: intergenic ORFs, de novo genes, GC content, foldability, genetic code, ancestral sequence reconstruction and more :)

11.01.2026 19:43 👍 48 🔁 24 💬 2 📌 0

Félicitations François ! 👏🎉

09.01.2026 13:26 👍 0 🔁 0 💬 0 📌 0

Dans un autre registre, les traces de sang sur les draps dans un logement ça peut aussi indiquer la présence de punaises de lits (piqûres sur les jambes et après les gens se grattent). Donc en tant que loueur c'est pas forcément un truc à souligner.

08.01.2026 20:14 👍 0 🔁 0 💬 0 📌 0