Pengcheng Zhou

B lymphocytes that enter the germinal center late preferentially differentiate into memory cells that recognize subdominant epitopes Using a dual-recombinase fate-mapping system to trace late-entry invader B cells in germinal centers, Zhou et al. show that across vaccination and influenza infection, invaders preferentially generate memory B cells, whose antibodies target subdominant epitopes. Their findings suggest that invader B cells—late arrivals to the GC—are an important source of immune memory diversification.

Online now: B lymphocytes that enter the germinal center late preferentially differentiate into memory cells that recognize subdominant epitopes

Pleased to share our work on late-invading germinal center B cells in @cp-immunity.bsky.social By developing a new dual-recombinase fate-mapping reporter system, we show that late-entry GC B cells preferentially differentiate into memory B cells that recognizing subdominant epitopes.

Thanks for highlighting our work!

B lymphocytes that enter the germinal center late preferentially differentiate into memory cells that recognize subdominant epitopes @cp-immunity.bsky.social
www.cell.com/immunity/ful... @rockefeller.edu

Macrophages direct location-dependent recall of B cell memory to vaccination Vaccines generate long-lived plasma cells and memory B cells (Bmems) that may re-enter secondary germinal centers (GCs) to further mutate their B cell…

Happy #DayofImmunology! Congrats @ramadhenni.bsky.social & Alexandra Carey Hoppé it's out (finally!) @cp-cell.bsky.social! Incredibly grateful to co-leads @mlmunier.bsky.social, Vanessa Venturi & Tony Kelleher & all brilliant folks @garvaninstitute.bsky.social & Kirby Inst. for fantastic collab! 🧵

Identification of antigen-presenting cell–T cell interactions driving immune responses to food The intestinal immune system must concomitantly tolerate food and commensals and protect against pathogens. Antigen-presenting cells (APCs) orchestrate these immune responses by presenting luminal ant...

I am excited to share our study showing how the immune system strikes a delicate balance between tolerating food and defending against helminth infections.
www.science.org/doi/10.1126/....

#Immunology by first release now @science.org

Plasma cells producing high-affinity antibodies dominate the plasma cell population through increased proliferation.

https://buff.ly/3BzpLmL

By Andrew MacLean, Michel Nussenzweig et al.

Photo of the Vinuesa lab members by the sea.

Hi 👋🏼 The Vinuesa lab has arrived at BlueSky! Follow us if you want to talk about all the exciting science going on in autoimmunity, genetics, and anything B cell-related 🧬 🧪