Graphical abstract from our new paper in Nucleic Acids Research with @saramaciasrna.bsky.social π§¬
DGCR8 prevents accumulation of endogenous dsRNA derived from Alu elements within mRNAs, avoiding aberrant activation of the interferon response.
academic.oup.com/nar/article/...
How does the piRNA pathway solve the self vs. non-self problem? π§¬
Since piRNAs come from single-stranded RNA, how does the cell choose the right ones? For years, "piRNA clusters" were seen as THE privileged source. But are they really special and earmarked for biogenesis? (1/19)
I wrote about my childhood friend Alexi Pretti. Please read it and share it and remember him as a human being. @theverge.com
ICE has detained at least 3,800 kids under the second Trump administration β more than 500 of whom were under 5 years old.
Children shouldn't be locked up by our government.
Alex Pretti.
Renee Good.
Say it out loud and say it with your chest. It was murder.
Not a "shooting"
Not a "execution"
Not a "mistake"
Murder. ( Homicide. Democide. Femicide. )
#3E #GoodvsEvil
Alex Pretti, wearing a green sweater with his VA badge on.
This is Alex Pretti.
This morning he was murdered by ICE. Six ICE agents held him down and shot him at point blank range. Alex was a nurse and researcher at the VA.
Our thoughts are with his loved ones and we stand united in action calling for the abolishment of ICE.
#ScientistsAgainstICE
Today, we lost another Minneapolis neighbor after multiple ICE agents pummeled him and shot him to death.
How many more people need to die or get shot before this ends?
President Trump, I am calling on you to put the American people and this American city first and get ICE out.
If Europe found a way for him to save face and move on, great. But Carney's speech was still spoken and was still true. The bell has rung.
A St. Paul resident says federal officers knocked on her door and asked her to identify Hmong and Asian households in her North End neighborhood last week.
The Department of Labor has just posted its second Nazi slogan (in the original, "Germany for Germans") in the last two days.
No one believes this is a coincidence.
They are telling America exactly who they are and what they intend.
Physicists' perspective on the future direction of condensates in Cell Biology.
arxiv.org/abs/2601.03677
Our Perspective article on the emerging role of retroelements in brain function and disease is now out in this week's edition of @cp-neuron.bsky.social!
@alexwhiteley.bsky.social
www.cell.com/neuron/fullt...
Absolutely thrilled to share the latest work from my lab focused on the variation and evolution of human centromeres among global populations! We assembled 2,110 human centromeres, identifying 226 new major haplotypes and 1,870 Ξ±-satellite HOR variants. www.biorxiv.org/content/10.6...
It's official! The #tidyomics blog is up! π
Here, the introductory post
tidyomics.github.io/tidyomicsBlo...
This blog aims to publish not only news about our community but also anything related to tidy interfaces, opinions, events, and more.
Plz share! π
@bioconductor.bsky.social #rstats
Molecular effects of transposable element sequences in mammalian cells #TESky
(Wen, MC.C., Welch, J.D. Genome Biol 26, 403 (2025)).
Interesting review of new-found functions of TEs in mammalian genomes, especially over the last three years.
doi.org/10.1186/s130... #TEWorldwide
gggenomes: A Grammar of Graphics for Comparative Genomics thackl.github.io/gggenomes/ #Rstats
Using proximity labeling and a derivatized galectin-3, scientists in the lab of Professor Mia Huang mapped glycanβprotein interactions that drive placental cell fusion, published in @pnas.org, offering new insight into placental development.
(1/10) How do diverse leukemia mutations converge on the same molecular program? In #RibackLab first manuscript @cp-cell.bsky.social, collaboration with @goodell-lab.bsky.social shows that disparate mutations rewire shared protein networks to form nuclear condensates called C-bodies.
How do pluripotent stem cells resist harmful interferon responses to safeguard development? Through total epigenetic lockdown of ligands, sensors and effectors of IFN-I. In our preprint, James Holt shares his PhD discoveries on the ground state of immune evasion π: www.biorxiv.org/cgi/content/...
For obvious reasons, I've become fascinated with retrotransposons. So we ( @alexwhiteley.bsky.social and I) wrote an article now out in Neuron @cellpress.bsky.social on how we think retrotransposons influence brain function and health! kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F...
#WeekendRead! #ToSenseOrNotToSense! #MysterySolved! Berouti, Wagner, Carell, @v-hornung.bsky.social &co show @cp-cell.bsky.social that RNase T2 & PLDs generate #TLR7 & #TLR8 agonistic ligands only if RNA does not contains pseudouridines explaining avoidance of self RNA sensing!
Want to help shaping the future of #Snakemake? Then participate in the Snakemake hackathon 2026 in Munich! There's still room as the maximum number of participants is not yet reached. You can register here: indico.cern.ch/e/snakemake-...
#sciworkflows #reproducibility
Your immune system remembers skin inflammation long after it resolves because of #interferon alpha!
Check out our new paper describing these findings just published at
@jimmunol.bsky.social πππ
It was amazing working on this with my role model @drshrutinaik.bsky.social
Last week @science.org mRNA initiation and termination are spatially coordinated | Science www.science.org/doi/10.1126/... from @anafiszbein.bsky.social @athmapai.bsky.social et al.
Hominoid-specific retrotransposons fuel regulatory novelty in early brain development , by @retrogenomics.bsky.social.
β‘οΈ www.cell.com/cell-genomic...
#LiveForever! Chen, Mao &co show @science.org that not all #cGAS are equals & that naked mole-rats one bears a 4 amino acid mutation which enhances DNA repair & when transferred in aged mice dampens frailty, hair graying, inflammatory & senescence markers! www.science.org/doi/10.1126/...
