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Jon Agirre

@glycojones

YSBL, Department of Chemistry, University of York, UK. I make, modify and fix stuff. Acta Cryst F main editor with Mark and Cristy. CCP4wg2 chair with Arnaud. Analyse glycan structures with Privateer: https://privateer.york.ac.uk #RealTimeChem [He/Him]

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09.05.2024
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Latest posts by Jon Agirre @glycojones

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Crystal structure of endo-β-N-acetylglucosaminidase HSα Structural analysis of the GH85 enzyme endo-β-N-acetylglucosaminidase HSα reveals a novel domain that is potentially involved in complex N-glycan recognition.

Ikuya Kurauchi et al.: Crystal structure of endo-β-N-acetylglucosaminidase HSα #EndoNAcetylglucosaminidases #GH85 #ComplexNGlycans ... #IUCr https://journals.iucr.org/paper?S2053230X26001214

04.03.2026 01:00 👍 4 🔁 2 💬 0 📌 0

Next to @ausbiocommons.bsky.social and @glycojones.bsky.social - good company 😊

12.02.2026 01:15 👍 4 🔁 1 💬 0 📌 0
CryoSift: an accessible and automated CNN-driven tool for cryo-EM 2D class selection
CryoSift: an accessible and automated CNN-driven tool for cryo-EM 2D class selection YouTube video by International Union of Crystallography

Have you checked out our latest Interview with Authors? The Editors chat to Mike Cianfrocco, Scott Stagg and Jan-Hannes Schäfer about their CryoSift tool youtu.be/ROlc_eueYfg

More interviews at are available at www.youtube.com/playlist?lis...

06.01.2026 15:18 👍 3 🔁 2 💬 0 📌 0

One of the coolest things going on here is that the GitHub repos contain Jupyter notebooks for you to try their software. In case you don't have Jupyter installed or don't know what it is: you can always upload the notebooks to Google Colab and run everything on their cloud services :)

22.10.2025 15:58 👍 6 🔁 3 💬 0 📌 0
CryoSift: an accessible and automated CNN-driven tool for cryo-EM 2D class selection
CryoSift: an accessible and automated CNN-driven tool for cryo-EM 2D class selection YouTube video by International Union of Crystallography

New interview alert! We had a chat with Mike Cianfrocco, Scott Stagg and Jan-Hannes Schäfer about their CryoSift tool – details in the thread. www.youtube.com/watch?v=ROlc...

11.12.2025 13:07 👍 10 🔁 9 💬 1 📌 1

Thanks to @actacrystf.iucr.org for highlighting our smart 2D selection tool CryoSift. You can test it yourself here cryosift.org

11.12.2025 16:48 👍 3 🔁 5 💬 0 📌 0
Preview
Interviews with Authors - YouTube

We have many other interviews you might find interesting – please have a look at our playlist and give them a watch, there are lots of interesting stories to discover: www.youtube.com/playlist?lis...

11.12.2025 13:07 👍 1 🔁 1 💬 0 📌 0

CryoSift uses a Convolutional Neural Network (CNN) for assessing the quality of 2D averages to enable the automatic selection of suitable particles for high-resolution reconstructions. The interview discusses aspects such as how to avoid bias, dealing with errors, automation in Cryo-EM and others.

11.12.2025 13:07 👍 1 🔁 1 💬 1 📌 0
CryoSift: an accessible and automated CNN-driven tool for cryo-EM 2D class selection
CryoSift: an accessible and automated CNN-driven tool for cryo-EM 2D class selection YouTube video by International Union of Crystallography

New interview alert! We had a chat with Mike Cianfrocco, Scott Stagg and Jan-Hannes Schäfer about their CryoSift tool – details in the thread. www.youtube.com/watch?v=ROlc...

11.12.2025 13:07 👍 10 🔁 9 💬 1 📌 1

One of the coolest things going on here is that the GitHub repos contain Jupyter notebooks for you to try their software. In case you don't have Jupyter installed or don't know what it is: you can always upload the notebooks to Google Colab and run everything on their cloud services :)

22.10.2025 15:58 👍 6 🔁 3 💬 0 📌 0

Great to see this article by @guptapenn.bsky.social is out! Kushol helped us interview @xtalmaker.bsky.social Vivian Stojanoff and @gabbygrowsxtals.bsky.social who published an article on careful sample preparation in crystallisation experiments, also part of #SAMPREP
www.youtube.com/watch?v=m34R...

10.10.2025 10:07 👍 4 🔁 3 💬 0 📌 0
Structure of Plasmodium vivax N-myristoyltransferase with the  NMT inhibitor IMP-1088
Structure of Plasmodium vivax N-myristoyltransferase with the NMT inhibitor IMP-1088 YouTube video by International Union of Crystallography

I'm incredibly proud to present this @actacrystf.iucr.org interview with Alex Mendez and Cydni Bolling on their first paper ever! The interview was co-led by Dr Graham Chakafana from Hampton University in the USA, who supervised the authors' undergraduate research.
www.youtube.com/watch?v=5rjI...

24.09.2025 16:30 👍 6 🔁 5 💬 1 📌 0
Preview
Structure of Plasmodium vivax N-myristoyltransferase with inhibitor IMP-1088: exploring an NMT inhibitor for antimalarial therapy The 1.8 Å resolution ternary structure of P. vivax N-myristoyltransferase in complex with IMP-1088 and myristoyl-CoA is presented. IMP-1088 is an N-myristoyltransferase inhibitor from a family of inhi...

The article we're discussing is "Structure of Plasmodium vivax N-myristoyltransferase with the NMT inhibitor IMP-1088", You can read the paper (🔓<- yes, it's open access!) here: journals.iucr.org/f/issues/202...

24.09.2025 16:30 👍 2 🔁 0 💬 0 📌 0
Structure of Plasmodium vivax N-myristoyltransferase with the  NMT inhibitor IMP-1088
Structure of Plasmodium vivax N-myristoyltransferase with the NMT inhibitor IMP-1088 YouTube video by International Union of Crystallography

I'm incredibly proud to present this @actacrystf.iucr.org interview with Alex Mendez and Cydni Bolling on their first paper ever! The interview was co-led by Dr Graham Chakafana from Hampton University in the USA, who supervised the authors' undergraduate research.
www.youtube.com/watch?v=5rjI...

24.09.2025 16:30 👍 6 🔁 5 💬 1 📌 0
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The World Directory of Crystallographers (WDC) offers an unparalleled compilation of expertise in the field.
It’s free to join and open to all crystallographers and other scientists employing crystallographic methods.
Add your name and be part of the mosaic:
🔗 www.iucr.org/people/wdc

12.09.2025 13:04 👍 3 🔁 3 💬 0 📌 0
DLS/CCP4 Workshop 2025

Just a few days left to register for the next Diamond/CCP4 Data Collection and Structure Solution Workshop! This is an excellent training course delivered at a unique location and close to the most wonderful time of the year. It also has LOTS of tutors per student! www.ccp4.ac.uk/schools/DLS-...

03.09.2025 16:11 👍 2 🔁 4 💬 0 📌 0
DLS/CCP4 Workshop 2025

Just a few days left to register for the next Diamond/CCP4 Data Collection and Structure Solution Workshop! This is an excellent training course delivered at a unique location and close to the most wonderful time of the year. It also has LOTS of tutors per student! www.ccp4.ac.uk/schools/DLS-...

03.09.2025 16:11 👍 2 🔁 4 💬 0 📌 0
FabG4 from Mycolicibacterium smegmatis
FabG4 from Mycolicibacterium smegmatis YouTube video by International Union of Crystallography

Indeed, our journal carries these contributions with pride. This might be a good time to revisit our video chat with Xinping, Prashit and Krystle (last year! time flies) www.youtube.com/watch?v=eZhv...

01.08.2025 11:07 👍 3 🔁 1 💬 0 📌 0
Two scientists looking at a computer screen

Two scientists looking at a computer screen

Excited to share this story on the protein crystallography CURE I developed and have been teaching for the last 3 years!

www.vassar.edu/news/student...

This course is supported by my #CottrellScholars Award from RCSA.

@rescorp.org
@vassar.bsky.social

#grantsinaction #biochemistry

31.07.2025 14:15 👍 24 🔁 7 💬 1 📌 2

We were pleased to publish some of the results from this course, some in our recent 'Empowering education through structural genomics' focused issue: journals.iucr.org/special_issu...

31.07.2025 15:20 👍 8 🔁 4 💬 1 📌 0

Happy World Rain Day! It’s raining…

– Cats and dogs (English)
– Old ladies and sticks (Welsh)
– Like a pissing cow (French)
– As from Esteri’s ass (Finnish)
– Penguins headfirst (Uruguayan Spanish)
– Pilot whales (Faroese)
– Chair legs (Greek)
– Wheelbarrows (Czech)
– Men (hallelujah)

29.07.2025 09:17 👍 1646 🔁 411 💬 109 📌 59

🏴󠁧󠁢󠁥󠁮󠁧󠁿🏴󠁧󠁢󠁥󠁮󠁧󠁿

27.07.2025 20:07 👍 1 🔁 0 💬 0 📌 0

Thanks for sharing — lovely photos.

27.07.2025 19:27 👍 0 🔁 0 💬 0 📌 0

AI chat bots behaving like science fiction AI chat bots because they were once trained on Asimov

25.07.2025 22:49 👍 1 🔁 0 💬 0 📌 1

Lost for words 😞

22.07.2025 18:34 👍 0 🔁 0 💬 0 📌 0
Preview
Interviews with Authors - YouTube

Just realised that we've been doing Interviews With Authors on YouTube for a whole year!

I'd really appreciate receiving comments about these, e.g. suggest a structural biologist you would like us to interview

Here's a playlist with all the videos we've done so far: www.youtube.com/playlist?lis...

18.07.2025 09:37 👍 6 🔁 6 💬 0 📌 0
ACA2025 attendees wearing cowboy hats in front of a billboard that says "See you in Calgary!"

ACA2025 attendees wearing cowboy hats in front of a billboard that says "See you in Calgary!"

ACA2025 attendee wearing cowboy hat in front of a billboard that says "See you in Calgary!"

ACA2025 attendee wearing cowboy hat in front of a billboard that says "See you in Calgary!"

ACA2025 attendees wearing cowboy hats in front of a billboard that says "See you in Calgary!"

ACA2025 attendees wearing cowboy hats in front of a billboard that says "See you in Calgary!"

ACA2025 attendee wearing cowboy hat in front of a billboard that says "See you in Calgary!"

ACA2025 attendee wearing cowboy hat in front of a billboard that says "See you in Calgary!"

Giddy up to Calgary! Stop by our #IUCr2026 booth at #ACA2025 to gear up for the 2026 Conference to get some Calgary Stampede merch, plan your trip, meet other attendees and more!

20.07.2025 15:28 👍 15 🔁 7 💬 0 📌 1
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Fascinating. Microsoft emailed me to say it was raising the price of Microsoft 365, but when i went to cancel it offered me me the old price — without all the AI bullshit.

It’s forcing AI on everyone and making them pay more for it, then only telling them they don’t have to if they try to cancel.

19.07.2025 03:11 👍 4137 🔁 1568 💬 37 📌 138

Welcome to the new normal in Erurope

Please use mosquito repellent

19.07.2025 06:48 👍 6 🔁 2 💬 0 📌 0

Interesting preprint, by the way. I will try to read it next week.

18.07.2025 16:06 👍 1 🔁 0 💬 0 📌 0