Farid Moussavi-Harami, MD

Work from Patrick Boyle at University of Washington shows population-based computational simulations elucidate mechanisms of focal arrhythmia following stem cell injection

Read more: doi.org/10.1016/j.yj...

Great new study with collaboration from the Regnier lab @uwbioe.bsky.social and the Kad lab at the University of Kent in the UK! Very cool spatially resolved single-molecule imaging. @ctmr-uw.bsky.social

Outstanding work!

Common-variant and rare-variant genetic architecture of heart failure across the allele-frequency spectrum Nature Genetics - Common-variant and rare-variant association analyses combining datasets from multiple populations yield insights into the genetic architecture of all-cause heart failure across...

Excited to see this published: rdcu.be/egHer

Common- and rare-variant genetic analyses of heart failure in >2 million individuals

🔘 Dozens of new common variant loci
🔘 Confirmation of rare damaging variation in "definitive" cardiomyopathy genes
🔘 A PRS modifies penetrance of TTNtv

Happy Persian New Year!

Happy new year!

Regulation of TTN as a mechanism of and treatment for heart failure: buff.ly/4b9AEZy

Dominic E. Fullenkamp comments on Yuri Kim et al. (buff.ly/3X7mW3Y)

Our paper led by J. Shin & A. Small evaluating the longitudinal penetrance of HCM alleles in the Mass General Brigham Biobank www.sciencedirect.com/science/arti... @jaccjournals.bsky.social #JACCAdv @broadinstitute.org @cgm-mgh.bsky.social @mgbresearch.bsky.social

Exciting work from my brother!

Bidirectional Risk Modulator Along the DCM-HCM Spectrum This cross-sectional study evaluates the association of BAG3 genetic variation with penetrance and longitudinal outcomes of dilated cardiomyopathy (DCM) and hypertrophic cardiomyopathy (HCM).

A coding variant in BAG3 protects against dilated cardiomyopathy but increases risk for hypertrophic cardiomyopathy and is found to modify the effects of pathogenic TTN variants
jamanetwork.com/journals/jam...

Congratulations, @moradishayan.bsky.social!

Unfortunately, either of us is at AHA scientific sessions. Happy to chat anytime about collaboration!