CBCB Newcastle

Very happy to host Fred Antson (University of York) today for a seminar! Stunning structures and functional insights into phage/virus capsids and DNA loading.

Mechanism and reconstitution of circadian transcription in cyanobacteria - Nature Structural & Molecular Biology Fang et al. reveal how a bacterial circadian clock turns genes on and off at the right times of day and use the purified proteins to drive circadian gene transcription in a test tube for days.

www.nature.com/articles/s41...

Fabian was quicker :) But yes, we have an open postdoc position in bacterial bioenergetics and membrane biology, using on B. subtilis as the model. Come join us! @cbcb-newcastle.bsky.social is a great place to work, and we are a friendly, international lab. Visa+IHS fees covered. #microsky

Happy holidays everyone from a not very wintry Newcastle!

Congratulations Laura, the latest CBCB PhD graduate heading for a science career!

Today, we are lucky to have Imane El Meouche from IAME, France to give a MCM seminar @medicalsciencesncl.bsky.social (chaired by @henrikstrahl.bsky.social) on antibiotics tolerance in E. Coli

Big congratulations Neha!

Now properly published at @natcomms.nature.com with few additional experiments incl. demonstration of Daptomycin's ability to depolarise non-growing cells.
See the original preprint-thread for a summary of our findings.
www.nature.com/articles/s41...
#microsky

MRC DiMeN Doctoral Training Partnership: Transcription in malaria Plasmodium organelles: Mechanisms and Drug Targets at Newcastle University on FindAPhD.com PhD Project - MRC DiMeN Doctoral Training Partnership: Transcription in malaria Plasmodium organelles: Mechanisms and Drug Targets at Newcastle University, listed on FindAPhD.com

Transcription in malaria Plasmodium organelles: Mechanisms and drug targets. Supervised by Yulia Yuzenkova and @nishaphilip.bsky.social.

www.findaphd.com/phds/project...

MRC DiMeN Doctoral Training Partnership: Global Pathogen, Local Impact: Genomic and Functional Dissection of S. Infantis in Peru at Newcastle University on FindAPhD.com PhD Project - MRC DiMeN Doctoral Training Partnership: Global Pathogen, Local Impact: Genomic and Functional Dissection of S. Infantis in Peru at Newcastle University, listed on FindAPhD.com

Global pathogen, local impact: Genomic and functional dissection of S. infantis in Peru. Supervised by Matt Bawn and @jomcinerney.bsky.social.
www.findaphd.com/phds/project...

MRC DiMeN Doctoral Training Partnership: Structural and Functional Analysis of Drug Resistance in Tuberculosis via a Novel MmpL3 Binding Site at Newcastle University on FindAPhD.com PhD Project - MRC DiMeN Doctoral Training Partnership: Structural and Functional Analysis of Drug Resistance in Tuberculosis via a Novel MmpL3 Binding Site at Newcastle University, listed on FindAPhD....

Structural and functional analysis of drug resistance in tuberculosis via a novel MmpL3 binding site. Supervised by @mycobacterium-ncl.bsky.social and @kshbeckham.bsky.social.

www.findaphd.com/phds/project...

MRC DiMeN Doctoral Training Partnership: Molecular mechanism of slow growth and antibiotic tolerance in Mycobacterium tuberculosis using single-molecule microscopy at Newcastle University on FindAPhD.... PhD Project - MRC DiMeN Doctoral Training Partnership: Molecular mechanism of slow growth and antibiotic tolerance in Mycobacterium tuberculosis using single-molecule microscopy at Newcastle Universit...

Molecular mechanism of slow growth and antibiotic tolerance in Mycobacterium tuberculosis using single-molecule microscopy. Supervised by @kevindwhitley.bsky.social and @mycobacterium-ncl.bsky.social.

www.findaphd.com/phds/project...

MRC DiMeN Doctoral Training Partnership: Unexpected role of RNA polymerase in development of Methicillin-Resistance in S. aureus (MRSA) at Newcastle University on FindAPhD.com PhD Project - MRC DiMeN Doctoral Training Partnership: Unexpected role of RNA polymerase in development of Methicillin-Resistance in S. aureus (MRSA) at Newcastle University, listed on FindAPhD.com

Unexpected role of RNA polymerase in development of Methicillin-Resistance in S. aureus (MRSA). Supervised by Nikolay Zenkin and Simon Foster.

www.findaphd.com/phds/project...

MRC DiMeN Doctoral Training Partnership: Resensitisation of antibiotic-tolerant Staphylococcus aureus small colony variants at Newcastle University on FindAPhD.com PhD Project - MRC DiMeN Doctoral Training Partnership: Resensitisation of antibiotic-tolerant Staphylococcus aureus small colony variants at Newcastle University, listed on FindAPhD.com

Resensitisation of antibiotic-tolerant Staphylococcus aureus small colony variants. Supervised by @henrikstrahl.bsky.social, @kateduncan.bsky.social, and @mycobacterium-ncl.bsky.social.

www.findaphd.com/phds/project...

MRC DiMeN Doctoral Training Partnership: Targeting thioredoxin reductase to combat antifungal resistance in Candida spp. at Newcastle University on FindAPhD.com PhD Project - MRC DiMeN Doctoral Training Partnership: Targeting thioredoxin reductase to combat antifungal resistance in Candida spp. at Newcastle University, listed on FindAPhD.com

Targeting thioredoxin reductase to combat antifungal resistance in Candida spp. Supervised by @alesdantas.bsky.social, Janet Quinn, and Francesco Del Carratore. @nclfungalgroup.bsky.social

www.findaphd.com/phds/project...

MRC DiMeN Doctoral Training Partnership: Hiding in plain sight: How multi-drug resistant pathogens evade detection and killing by human neutrophils at Newcastle University on FindAPhD.com PhD Project - MRC DiMeN Doctoral Training Partnership: Hiding in plain sight: How multi-drug resistant pathogens evade detection and killing by human neutrophils at Newcastle University, listed on Fin...

Hiding in plain sight: How multi-drug resistant pathogens evade detection and killing by human neutrophils. Supervised by @ruamicro.bsky.social, Marie Phelan, and @jleslie1.bsky.social.

www.findaphd.com/phds/project...

Looking for a PhD opportunity in Microbiology? Consider joining one of the UK's leading microbiology research clusters at Newcastle University. See the thread for MRC DTP studentships currently advertised. @medicalsciencesncl.bsky.social @sagencl.bsky.social @cbcb-newcastle.bsky.social #microsky

You were already one of us. Now just under the same roof!

How do SMC complexes load onto DNA to get ready for loop extrusion?

@roisnehamelinf.bsky.social & co discovered that Wadjet, an SMC complex involved in bacterial DNA immunity, performs some impressive molecular gymnastics 🤸‍♂️🤸‍♂️🤸‍♂️.

Check out the new paper: www.cell.com/molecular-ce...

It was great to have Mark visit us today. Many great science discussions and hopefully new collaborations to start!

Monitoring single cell bioenergetic status and cell lysis in dense and differentiating Bacillus subtilis cultures Bacillus subtilis is a major model organism for studying population heterogeneity in clonal bacterial cultures due to its high genetic tractability and ability to differentiate into subpopulations wit...

A new methods paper from us, this time with a focus on reliable monitoring membrane potential and cell lysis at different growth stages and cell densities. Also, note the surprisingly high level of background lysis in seemingly healthy B. subtilis cultures.
www.biorxiv.org/content/10.1...

Fascinating seminar by Prof @gebhardlab.bsky.social on ‘Building bacterial bridges – How an ancient bacterial trait can help us build the infrastructure of the future’ and visit at @cbcb-newcastle.bsky.social (hosted by @henrikstrahl.bsky.social) #bacillus #spores

Don’t miss your chance #Newcastle, tickets for #PINT25 are out! @pintofscience.uk @pintsworld.bsky.social
More info for venues and tickets here pintofscience.co.uk/events/newca...
Repost appreciated :)

The role of membrane perturbations in antibiotic resistant Gram-negative bacteria at Newcastle University on FindAPhD.com PhD Project - The role of membrane perturbations in antibiotic resistant Gram-negative bacteria at Newcastle University, listed on FindAPhD.com

The role of membrane perturbations in antibiotic resistant Gram-negative bacteria. Supervised by @davychang.bsky.social, ‬Margarita Staykova, Mark Geoghegan and @adwol.bsky.social.

www.findaphd.com/phds/project...

New lysins for medically and environmentally important Mycobacteriales at Newcastle University on FindAPhD.com PhD Project - New lysins for medically and environmentally important Mycobacteriales at Newcastle University, listed on FindAPhD.com

New lysins for medically and environmentally important Mycobacteriales. Supervised by @lislowe.bsky.social and Paul James.

www.findaphd.com/phds/project...

Dissecting Gram-negative envelope biogenesis to understand drug delivery in Gram-negative pathogens at Newcastle University on FindAPhD.com PhD Project - Dissecting Gram-negative envelope biogenesis to understand drug delivery in Gram-negative pathogens at Newcastle University, listed on FindAPhD.com

Dissecting Gram-negative envelope biogenesis to understand drug delivery in Gram-negative pathogens. Supervised by Manuel Banzhaf, @thecopperdoctor.bsky.social and @henrikstrahl.bsky.social.

www.findaphd.com/phds/project...

Microbial metal-head: the integrated roles of metal homeostasis in host-pathogen interaction at Newcastle University on FindAPhD.com PhD Project - Microbial metal-head: the integrated roles of metal homeostasis in host-pathogen interaction at Newcastle University, listed on FindAPhD.com

Microbial metal-head: the integrated roles of metal homeostasis in host-pathogen interaction. Supervised by @ruamicro.bsky.social, @thecopperdoctor.bsky.social and Manuel Banzhaf.

www.findaphd.com/phds/project...

Adding functionality to C. difficile’s armour – integrative structural biology studies of SlpA and CWPs at Newcastle University on FindAPhD.com PhD Project - Adding functionality to C. difficile’s armour – integrative structural biology studies of SlpA and CWPs at Newcastle University, listed on FindAPhD.com

Adding functionality to C. difficile's armour; integrative structural biology studies of SlpA and CWPs. Supervised by @pssalgado.bsky.social, Peter Chivers, and Agnieszka Bronowska.

www.findaphd.com/phds/project...

Structure and functions of the novel type of RNA polymerases and their application in synthetic biology and biotechnology at Newcastle University on FindAPhD.com PhD Project - Structure and functions of the novel type of RNA polymerases and their application in synthetic biology and biotechnology at Newcastle University, listed on FindAPhD.com

Structure and functions of the novel type of RNA polymerases and their application in synthetic biology and biotechnology. Supervised by Nikolay Zenkin and Ehmke Pohl.

www.findaphd.com/phds/project...

Single-molecule analysis of the bacterial chromosome origin Basal Unwinding System (BUS) at Newcastle University on FindAPhD.com PhD Project - Single-molecule analysis of the bacterial chromosome origin Basal Unwinding System (BUS) at Newcastle University, listed on FindAPhD.com

Single-molecule analysis of the bacterial chromosome origin Basal Unwinding System (BUS). Supervised by @heathmurraylab.bsky.social and Aakash Basu.

www.findaphd.com/phds/project...