Babis Pappas

Happy to share that our work on phosphate leaving groups has been selected as the supplementary cover image for the latest issue of @jacs.acspublications.org

Credit to @Ella Maru for the great design.

pubs.acs.org/doi/10.1021/ja…

Tailored Phosphate Leaving Groups Direct Pathway-Dependent Self-Assembly Phosphate esters and anhydrides are central to biology, storing and transferring chemical energy to sustain processes from metabolism to translation. Among them, acyl phosphates are highly reactive, y...

We are happy to share our article, now published in @jacs.acspublications.org !🎉Leaving groups that do not really leave! Congrats to Arti for showing that phosphate leaving groups persist after amide bond formation, affecting the supramolecular properties of the system.
pubs.acs.org/doi/10.1021/...

Just out in @ChemRxiv! Switchable amino acyl phosphates! We show how azobenzene-embedded acyl phosphates enable photoperiodic control over non-equilibrium self-assembly.

chemrxiv.org/engage/chemr...

Thank you very much @gomobel.bsky.social for highliting our work on @chemistryworld.com. Chiral acyl phosphates meet self-assembly..! Thanks also @claudiabonfio.bsky.social and @jeannecrassousiscr.bsky.social for the very nice comments about our work!!

Just out in @ChemRxiv
More than a leaving group!! We show how phosphate leaving groups can regulate reaction pathways and drive orthogonal amide bond formation. Well done Arti!

chemrxiv.org/engage/chemr...

Thank you @ella-maru.bsky.social for the great design.

Just out in @chemrxiv.org

Click or Acyl transfer? We show how amino acyl phosphates and peptide nucleophiles direct acyl transfer vs click chemistry, enabling temporal control in abiotic networks. Well done
@debjyoti8419.bsky.social

chemrxiv.org/engage/chemr...

Inside Back Cover: Chirality Makes or Breaks Chemically Driven Self‐Assembly In their Research Article (e202508481), Lenard Saile and Kun Dai et al. describe a feedback mechanism that controls non-equilibrium systems. Enantiomeric aminoacyl phosphates, depicted as left and ri...

Happy to see the work from @lenardsaile.bsky.social
and Kun Dai highlighted #onTheCover of @angew_chem
(inside back cover). Thanks @EllaMaru
for the great design. Chiral aminoacyl phosphates!!!

onlinelibrary.wiley.com/doi/full/10....

onlinelibrary.wiley.com/doi/10.1002/...

onlinelibrary.wiley.com/doi/10.1002/...

We are happy to share that our article on chirality-driven non-equilibrium assembly is published in @angewandtechemie.bsky.social !Congrats to Lenard and Kun for showing how left and right handed aminoacyl phosphates enable control over kinetics and pathways onlinelibrary.wiley.com/doi/10.1002/an…

Phase behavior and pathway-selective oligomerization driven by amino acid side-chain recognition What basic ingredients enable amino acid side-chain recognition and assembly without complex biological machinery? We show that even simple molecular sorters can organize amino acids in space and time...

We are very happy to share our recent publication in
@cp-chem.bsky.social on abiotic aminoacylation and side chain recognition through compartmentalization!
Congrats to Kun and Lenard, and everyone else involved in the work!
www.cell.com/chem/fulltex...

Very nice work Ivan! Congratulations to everyone involved!

We are looking for a postdoctoral researcher to work on a project funded by the Boehringer Ingelheim Foundation on dynamic peptide self-assembly.

📄 Full position ad:
bit.ly/4jAIrmg

📅 Application deadline: May 31, 2025

#Postdoc #ChemistryJobs #SystemsChemistry #AcademicJobs #Freiburg #livMatS

Very cool work!

Congratulations Mahesh for successfully defending your thesis! The first PhD student from the group. An amazing research journey ends here and we wish you all the best for your future research adventures!!

Thank you Oliver!

Thank you Rienk!

Self-assembly of the phosphate esters give rise to covalent self-sorting in oligomerization reactions.

The chemical structures of the phosphate esters can be tailored to direct the synthesis of specific sequences.

We show how side chain reactivity and pre-organisation of phosphate esters can drive selective peptide bond formation from a pool of amino acids.

Selective peptide bond formation via side chain reactivity and self-assembly of abiotic phosphates - Nature Communications In biological processes, peptide bonds are formed via reactive phosphate-containing intermediates, facilitated by compartmentalized environments. Here, the authors use aminoacyl phosphate esters that ...

Happy for our published article in @NatureComms
showing the departure from randomness in peptide bond formation through aminoacyl phosphate esters. Congratulations to Arti and everyone involved.@livMatS_UniFR
@UniFreiburg
@FreiburgChem
@FitFreiburg

nature.com/articles/s41...

We show how side chain reactivity and pre-organisation of phosphate esters can drive selective peptide bond formation from a pool of amino acids.

We have a PhD position on reaction networks driven by aminoacyl phosphate esters funded from @ercresearch.bsky.social at @uni-freiburg.de.
Deadline for application is 20/03/25. More information can be found here: static1.squarespace.com/static/5fc39...