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Luis Cobar

@prime5222

Salvadoran Neuroscientist πŸ‡ΈπŸ‡» PhD | Senior Research Advisor @ims-mrl.bsky.social‬ | previously @kavlintnu.bsky.social‬ (Nigro Lab) | Opinions my own | πŸ‡ΉπŸ‡Ό πŸ‡ΈπŸ‡¬ πŸ‡³πŸ‡΄ πŸ‡¬πŸ‡§

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22.02.2025
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Latest posts by Luis Cobar @prime5222

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Our paper is out in @natneuro.nature.com!

www.nature.com/articles/s41...

We develop a geometric theory of how neural populations support generalization across many tasks.

@zuckermanbrain.bsky.social
@flatironinstitute.org
@kempnerinstitute.bsky.social

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10.02.2026 15:56 πŸ‘ 274 πŸ” 100 πŸ’¬ 7 πŸ“Œ 1
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Neuroscience methods - YouTube Nanocourse: Approaches to Study Neural Circuits This course was taught by Anita Autry, Tiago GonΓ§alves, and Luke Sjulson at Albert Einstein College of Medici...

Neuroscience students asked us to teach a PRACTICAL course on experimental methods, and it is now on YouTube!

Please like and repost to help us get the word out!

www.youtube.com/playlist?lis...

Lecture 1: Signals and data acquisition
Focusing on hardware, digital/analog I/O, synchronization
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13.12.2024 11:32 πŸ‘ 424 πŸ” 205 πŸ’¬ 19 πŸ“Œ 17
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various computational neuroscience / MEEG / LFP short courses and summer schools

πŸ“† updated for 2026!

list of summer schools & short courses in the realm of (computational) neuroscience or data analysis of EEG / MEG / LFP: πŸ”— docs.google.com/spreadsheets...

19.12.2025 16:37 πŸ‘ 100 πŸ” 60 πŸ’¬ 3 πŸ“Œ 0
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How do biological agents learn for the future?

Our perspective piece on the value of prospective learning in neuroscience is finally out. This is part of a long running collaboration with @kordinglab.bsky.social & Josh Vogelstein (as well as many other people)

www.sciencedirect.com/science/arti...

17.12.2025 17:06 πŸ‘ 90 πŸ” 29 πŸ’¬ 7 πŸ“Œ 1
The Biggest Breakthroughs in Mathematics: 2025
The Biggest Breakthroughs in Mathematics: 2025 YouTube video by Quanta Magazine

It was a big year for mathematics. youtu.be/hRpcWpAeWng

18.12.2025 20:18 πŸ‘ 47 πŸ” 18 πŸ’¬ 0 πŸ“Œ 2
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My first paper just got published last week!
*Longitudinal tracking of neuronal activity from the same cells in the developing brain using Track2p*
elifesciences.org/articles/107...

18.12.2025 10:59 πŸ‘ 73 πŸ” 12 πŸ’¬ 5 πŸ“Œ 2
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Characteristics and mechanisms of cognitive impairment in Parkinson disease Nature Reviews Neurology, Published online: 03 December 2025; doi:10.1038/s41582-025-01163-xCognitive impairment is one of a range of non-motor symptoms that people with Parkinson disease (PD) can experience in addition to the hallmark motor symptoms of the disease. In this Review, Oikonomou et al. outline the epidemiology and natural history of cognitive decline in PD and related disorders, and discuss the key underlying pathophysiological factors and mechanisms.

New online! Characteristics and mechanisms of cognitive impairment in Parkinson disease

04.12.2025 09:10 πŸ‘ 3 πŸ” 2 πŸ’¬ 0 πŸ“Œ 0

No siento que sea precisamente una arma, pero es fΓ‘cil ver como actores maliciosos ocupan estas herramientas para deshacer y vulnerar el buen diΓ‘logo diΓ‘logo. Le harΓ­a bien a Europa el dejar los excesos de silicon valley y tener un marco jurΓ­dico digital que promueva y defienda la democracia

01.12.2025 20:44 πŸ‘ 2 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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CIENCIA | La neurociencia de la pΓ©rdida de peso El desarrollo de nuevas drogas para la pΓ©rdida de peso ha abierto el debate sobre el lugar de estos fΓ‘rmacos en medio de una epidemia mundial de obesidad.

Al cambiar de trabajo, tuve la necesidad de aprender varias cosas y ponerlas dentro del marco de mi experiencia previa. Quise escribir lo poco que he aprendido en los ΓΊltimos meses y hacer un breve texto para gente de mΓ­ paΓ­s. Me gustarΓ­a compartirlo:

gatoencerrado.news/2025/11/28/c...

01.12.2025 20:17 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

Tactile responses in the mouse perirhinal cortex show invariance to physical features of the stimulus https://www.biorxiv.org/content/10.1101/2025.08.15.670508v1

21.08.2025 16:15 πŸ‘ 4 πŸ” 1 πŸ’¬ 0 πŸ“Œ 1

Our first steps into sensory processing is now online!
Work spearheaded by Rejwan Salih from experiments by @prime5222.bsky.social and FranΓ§ois Pauzin
We were lucky to receive guidance from Davide Zoccolan on the analytical methods.
#neuroskyence

21.08.2025 17:01 πŸ‘ 12 πŸ” 3 πŸ’¬ 2 πŸ“Œ 0
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We are super happy to announce the fourth edition of School of Ideas in Neuroscience! Come to Warsaw in September for in-depth talks, discussions and workshops that will help you to make sense of your data! The deadline for registration is July 21, 2025.

07.07.2025 19:58 πŸ‘ 16 πŸ” 7 πŸ’¬ 1 πŸ“Œ 3
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We are super happy to announce the third Workshop of Ideas in Neuroscience! We will once again look critically at assumptions of modern neuroscience: what does it mean that the brain encodes information? Is this a useful approach, or a metaphor that blurs our vision?

24.04.2025 18:44 πŸ‘ 47 πŸ” 20 πŸ’¬ 2 πŸ“Œ 3
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Two-photon voltage imaging with rhodopsin-based sensors The recent advances in sophisticated optical techniques, coupled with two-photon sensitive genetic voltage indicators (GEVIs), have enabled in-depth voltage imaging in vivo at single spike and single-...

doi.org/10.1101/2024...

09.04.2025 15:10 πŸ‘ 1 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0
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Why Everything in the Universe Turns More Complex | Quanta Magazine A new suggestion that complexity increases over time, not just in living organisms but in the nonliving world, promises to rewrite notions of time and evolution.

Possible answers to Fermi’s β€œparadox” abound. For instance, maybe alien civilizations destroy themselves before they can become interstellar wanderers. A new proposal challenges that bleak conclusion.

03.04.2025 20:04 πŸ‘ 39 πŸ” 11 πŸ’¬ 0 πŸ“Œ 2
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Many of us use 2p scopes to image 3D volumes of brain. But then we analyze the data plane by plane, resulting in duplicated neurons, missed neurons, and low s/n. Let's go 3D!

Suite3D: Volumetric cell detection for two-photon microscopy
by @haydari.bsky.social & team.
www.biorxiv.org/content/10.1...

01.04.2025 11:10 πŸ‘ 90 πŸ” 27 πŸ’¬ 0 πŸ“Œ 2
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Opinion | What Autocrats Want From Academics: Servility In 1931, Italian scholars were made to take loyalty oaths. Will that happen to us?

"On October 8, 1931, a law went into effect requiring every Italian university professor to sign an oath pledging their loyalty to the government of Benito Mussolini. Out of over 1,200 professors in the country, only 12 refused. All of them were immediately fired." www.chronicle.com/article/what...

21.03.2025 22:45 πŸ‘ 13059 πŸ” 6222 πŸ’¬ 311 πŸ“Œ 421
The World's Observatory of the Mind | OpenScope
The World's Observatory of the Mind | OpenScope YouTube video by Allen Institute

youtu.be/13r9n0pSDLc?...

16.03.2025 16:22 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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Belelli et al. explore the role of GABA in integrating brain and GI tract functions. They discuss how gut bacteria use and produce GABA, influencing brain activity and providing potential therapeutic opportunities for brain disorders. tinyurl.com/yc283kby

16.03.2025 16:20 πŸ‘ 1 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0
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In chaotic systems, the smallest fluctuations get amplified. As scientist Edward Lorenz put it in the 1960s and 70s, even a seagull flapping its wings might eventually make a big difference to the weather. Here's how scientists came to understand what chaos is, and how to wrangle it:

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14.03.2025 17:37 πŸ‘ 94 πŸ” 29 πŸ’¬ 1 πŸ“Œ 2
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Academic mentees thrive in big groups, but survive in small groups - Nature Human Behaviour Using longitudinal genealogical data on mentor–mentee relations and their publications, the authors find that mentees trained in larger groups tend to exhibit superior academic performance compared wi...

www.nature.com/articles/s41...

15.03.2025 04:44 πŸ‘ 1 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0
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Activism and Science: Anne Urai and Clare Kelly on responding to the climate and biodiversity crises How an economic framework may inspire new ways to tackle the climate crisis.

I spoke about science and activism with @elife.bsky.social, together with @clarekelly.bsky.social:
elifesciences.org/interviews/1...

14.03.2025 10:20 πŸ‘ 21 πŸ” 11 πŸ’¬ 0 πŸ“Œ 0
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in our new lab work, we find that:

natural forgetting & induced amnesia share common impaired neural dynamics

this work was funded by multiple #NIH grants that supported students, postdocs, & the science, all with the goal of healing disorders of memory & the brain

www.cell.com/cell-reports...

13.03.2025 16:57 πŸ‘ 24 πŸ” 12 πŸ’¬ 1 πŸ“Œ 0
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Miles de personas, sobre todo mujeres, se manifestaron este sΓ‘bado en San Salvador para conmemorar el #8M. La marcha iba encabezada por el movimiento anti minerΓ­a metΓ‘lica y ecologistas. Las consignas iban contra la violencia, los feminicidios y los desaparecimientos que siguen ocurriendo.

08.03.2025 17:11 πŸ‘ 3 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0
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Interested in using #CEBRA for modeling neural &/or behavioral (or both) dynamics? Check out the newest demo notebook to help you get started! πŸš€

πŸ“ www.nature.com/articles/s41...
πŸ’» cebra.ai/docs/demo_no...

07.03.2025 00:01 πŸ‘ 32 πŸ” 3 πŸ’¬ 0 πŸ“Œ 1
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A trans-synaptic nanocolumn aligns neurotransmitter release to receptors - Nature Synaptic vesicle fusion, as evoked by action potentials, is confined to presynaptic protein nanoclusters, which are closely aligned with concentrated postsynaptic receptors and their scaffolding prote...

www.nature.com/articles/nat...

07.03.2025 03:35 πŸ‘ 1 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0
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β€˜Creepy’ puppets may have starred in rituals at ancient Central American pyramid Detachable heads of marionettelike figures may have swiveled on a string more than 2000 years ago

β€˜Creepy’ puppets may have starred in rituals at ancient Central American pyramid | Science | AAAS www.science.org/content/arti...

05.03.2025 12:58 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0