Christopher Frøhlich

Postdoctoral Research Fellow at the Department of Medical Biology (296377) | UiT The Arctic University of Norway Job title: Postdoctoral Research Fellow at the Department of Medical Biology (296377), Employer: UiT The Arctic University of Norway, Deadline: Thursday, March 26, 2026

Looking for a PostDoc in molecular biology and structural biology ?

Check out the position in my group:

www.jobbnorge.no/en/available...

A reprogrammed genetic code consisting of 32 distinct amino acids Abstract. Sense codon reassignment enables ribosomal incorporation of nonproteinogenic amino acids (npAAs) at any of the 61 sense codons. Because npAAs rep

doi.org/10.1093/nar/...

Sometimes, adaptation to one #antibiotics can make bacteria more vulnerable to other drugs. #CollateralSensitivity.

💡 By following the evolution of a β-lactamase, we uncovered how mutations can both create and mitigate such collateral sensitivity networks.

www.biorxiv.org/content/10.6...

Evolution tunes functional sub-state interconversion to boost enzyme function Enzymes do not operate as static structures, but continuously fluctuate between different conformations. Enzymes therefore dynamically sample conformations with varying catalytic activity. However, it...

🚨PREPRINT🚨

Enzyme function does not rely only on static structure 🧩, but also on the rate at which functional sub-states interconvert ⏱️, making this interconversion subject to natural selection 🧬.

#OXA-48 #ceftazidime #enzymeevolution

www.biorxiv.org/content/10.6...

Living in the Arctic 🥶 means Christmas comes early 🎁🥳

10 MNOK (≈1 MUSD) Early Career Investigator grant from the Research Council of Norway to work with the fabulous @bunzela.bsky.social (Max Planck Institute) on uncovering the molecular mechanisms of antibiotic resistance.

#AMR #beta-lactamases

APC24-7, a covalent combination of boronic acid and chelator moieties, restores β-lactam efficiency against metallo-β-lactamase-producers | mSphere The ability of bacteria such as Klebsiella pneumoniae and Escherichia coli to circumvent antimicrobial chemotherapy has become a global public health crisis. The high prevalence of β-lactamase enzymes...

Interested in #β-lactamase inhibitors? 🧪

Our new #mSphere paper shows how a covalent boronic-acid + chelator fusion ⚗️ can restore β-lactam susceptibility in metallo-β-lactamase producers, even in variants that are difficult to inhibit with #taniborbactam.

journals.asm.org/doi/full/10....

Is it too early for a year review? 🤔

Research stays at ETH Zürich with Adrian Bunzel and at UBC Vancouver with Nobu 🤓.

Now I’m moving labs to start as Associate Professor at UiT, which means organising freezer contents 📦.

Two β-lactamase evolution preprints coming soon 🧬.

Stay tuned!

Functional sub-states link conformational landscapes and protein evolution The intrinsic conformational flexibility of proteins creates structural heterogeneity, giving rise to conformational ensembles within the energy lands…

🔄 #Enzymes can adopt multiple #conformations.

⚡ Some of these act as functional sub-states.

📚 We summarised recent studies, the methods used to uncover these hidden states, and the challenges ahead in linking them to #proteinevolution.

www.sciencedirect.com/science/arti...

Transparent peer review to be extended to all of Nature’s research papers From today, all new submissions to Nature that are published will be accompanied by referees’ reports and author responses — to illuminate the process of producing rigorous science.

Nature goes full open review!

I have complicated feelings about how and when this was achieved!

And they should be apparent to you after even a moment’s thought about the subtext here!

www.nature.com/articles/d41...

I highly recommend this conference, i thoroughly enjoyed the 2022 meeting 👇🏻

#JournalClub

🚨 Out Now!

A short read describing a xanthone-derived antibiotic which has multifaceted mode of action.

#MicroSky #AMR

www.nature.com/articles/s41...

Three PhD positions | Computational protein design Three PhD postiions in computational protein design

🔬 Join us! We are hiring three PhD students to advance enzyme design and develop photoenzymes for carbon capture and nitrogen fixation. If you are passionate about protein engineering, computational modeling, or synthetic biology, check out the job openings!

📌 www.mpg.de/24336572/phd...

🔬 PhD in Antibiotic Resistance Evolution – Join Us in the Arctic! ❄️

Passionate about enzymes and tackling antibiotic resistance?🧬✨

🔍 We’re looking for candidates with experience in:
✅ Genetic manipulation
✅ Protein expression & purification
✅ Enzyme biochemistry

🔗 Apply now: lnkd.in/eZRrgJKF

Biofilm selection constitutively activates c-di-GMP synthesis by the bifunctional enzyme MbaA Biofilms, in which microbes are encased within a self-produced matrix, represent the primary mode of microbial life. Yet, our understanding of the molecular mechanisms governing biofilm formation rema...

📣 Preprint Alert: How can evolution recruit existing enzymes during bacterial lifestyle changes?

Discover how mutations in a bifunctional enzyme 🔄 alter bacterial c-di-GMP metabolism, decoupling it from external polyamine signaling, and steering cells from a planktonic to a biofilm lifestyle 🦠

Call for postdoc candidates interested in applying for an MSCA Postdoctoral Fellowship in Enzyme Evolution UiT The Arctic University of Norway has established «The Arctic MSCA-PF program» (uit.no/project/arcticmsca) to recruit excellent young researchers planning to apply for a Marie Skƚodowsk

🌟 Enzyme Evolution: Marie Curie Fellowship in Tromsø! 🌟

Are you a late-stage PhD student or postdoctoral scholar specializing in biochemistry, molecular biology, or a related discipline? Connect with us to explore the potential for a MSCA collaboration.

euraxess.ec.europa.eu/jobs/309710

Are you interested in biofilms and how evolution regulates them?

Follow @oeyvindml.bsky.social PhD defence online. 1045 Central European time!

Here is the link to the live stream: uit.cloud.panopto.eu/Panopto/Page...

Epistasis arises from shifting the rate-limiting step during enzyme evolution of a β-lactamase Nature Catalysis - The reasons for epistasis, wherein mutations interact non-additively, are often not fully understood. Now it is found that shifting the rate-limiting step from substrate binding...

Are you interested in how #epistasis shapes the AMR evolution?

We showed that epistasis can be caused by independently modulating substrate binding and the chemical step ultimately changing the rate-limiting step in the catalytic cycle. @NatureCatalysis

Full read: rdcu.be/dzqjk

Epistasis arises from shifting the rate-limiting step during enzyme evolution of a β-lactamase Nature Catalysis - The reasons for epistasis, wherein mutations interact non-additively, are often not fully understood. Now it is found that shifting the rate-limiting step from substrate binding...

Are you interested in how #epistasis shapes the AMR evolution?

We showed that epistasis can be caused by independently modulating substrate binding and the chemical step ultimately changing the rate-limiting step in the catalytic cycle. @NatureCatalysis

Full read: rdcu.be/dzqjk

Call for postdoc candidates interested in applying for a MSCA Postdoctoral Fellowship in Enzyme and ... UiT The Arctic University of Norway has established «The Arctic MSCA-PF program» (uit.no/project/arcticmsca) to recruit excellent young researchers planning to apply for a Marie Skƚodowska-Curie Po...

Postdoc Opportunity UiTNorgesarktis! 🇳🇴

🧪Join our Arctic MSCA-PF program in Enzyme & AMR evolution. 24-months MSCA in Tromsø's stunning landscape.

⏱️Apply by Feb 16: 3-page CV & 2-page proposal to cfr016@uit.no.

#sciencejobs #postdocposition
euraxess.ec.europa.eu/jobs/189491

🌟Exciting News! Our AMR & Biofilms research just received an 8M kroner grant from #HelseNord. Big thanks for supporting young researchers and fueling scientific innovation. Grateful to all who've contributed to this success. Looking forward to what comes next.