Agostinho Carvalho

Join us for this exciting meeting! @embo.org Workshop "Pathogen Immunity and Signalling", 8-12 June, 2026, Leiden, The Netherlands meetings.embo.org/event/26-pat...

The fungi living in the body play an important role in health – here’s what you should know about the ‘mycobiome’ The ‘mycobiome’ refers to the hundreds of species of fungi that normally live on and in our body.

Looking for something to read with your tea this weekend? Try this new explainer on the #mycobiome! Learn about the 🍄fungi that live in your body, and why this matters for your health. New from me in The Conversation:
#immunosky 🧪

theconversation.com/the-fungi-li...

Fancy doing a PhD on #fungi ? 🍄 I'm co-supervising a project on the MIDTP program with Dr Ayesha Rahman - follow the link for project details and how to apply! #FindAPhD #immunosky 🧪
www.birmingham.ac.uk/about/colleg...

📢 Save the Date! 🎉
The next TIMM Congress will take place 10–13 September 2027 in Antwerp, Belgium!
We can’t wait to see you there – mark your calendars! 🗓️✨ #TIMM13 #Antwerp2027

🔬 Advanced Seminars are back this October at ICVS!
Starting Oct 2 | 1 PM | A0.03 with Bruno Almeida – IPLEXMED: Driving the Next Generation of Diagnostics from Lab to Life.
Don’t miss this month’s top talks on cancer, ALS, climate & more!
#ICVSAdvancedSeminars

Congratulations, Salome!

ICVS will be at the European Researchers' Night 2025!

Join us at Forum Braga on Sept 26, from 2:30 PM to midnight, for experiments, workshops, and more. Come meet our researchers and explore the world of science!
Free entry! #NEI2025 #ICVS #ScienceForAll

Drug-resistant fungus Candidozyma auris confirmed to spread rapidly in European hospitals: ECDC calls for urgent action The latest survey from ECDC, the fourth of its kind, confirms that Candidozyma auris (formerly Candida auris) continues to spread quickly across European hospitals.

#JustPublished!
Drug-resistant fungus #CandidozymaAuris is spreading rapidly in European hospitals. #ECDC calls for urgent action.

📈 Cases are rising, outbreaks are larger, and several countries now report local transmission.

Press release: bit.ly/46uR1iK
#CandidaAuris #HAI #IDsky #EpiSky #AMR

✨📄 What about the untapped therapeutic potential of the immune response in invasive aspergillosis ? Here’s some rational, pre-clinical and clinical evidence. Huge thanks to our amazing 🌍 team!
🔗 bit.ly/46kajHr
@simonfeys.bsky.social @agocarvalho.bsky.social @martinhoenigl.bsky.social

Aspergillus fumigatus dsRNA virus promotes fungal fitness and pathogenicity in the mammalian host - Nature Microbiology A mycovirus infecting the pathogenic fungus Aspergillus fumigatus enhances its stress tolerance and virulence in mice.

🚨 Fungi + viruses + mammalian lungs? Buckle up! Our new paper in
@natmicrobiol.nature.com
uncovers the story of a deadly fungus and its gnarly viral hitchhiker — and how this duo may change how we diagnose & treat fungal disease 🍄🫁🚨 doi.org/10.1038/s415... ⬇️

Research Associate (PDRA) in Fungal Infection Biology :Oxford Road

We are recruiting two Research Associates! Funded by the
@wellcometrust.bsky.social , join us to work on Mucorales adaption in collaboration with Becky Hall (University of Kent) www.jobs.manchester.ac.uk/Job/JobDetai...
Deadline: 1st October

Isto não é uma decisão de um Ministério da Educação que governa de acordo com a evidência técnica e científica.
É uma lamentável cedência populista a quem não se importa de aumentar as gravidezes indesejadas e a vulnerabilidade dos que não têm recursos económicos para aceder à formação essencial.

Our body is a mosaic of fungi. Some scientists think they could be influencing our brain The fungi within our bodies may have a much greater effect on our health than we've long given them credit for.

New BBC article on fungal infections in which we are quoted:
www.bbc.co.uk/future/artic...

🖼️"From Artifacts to Facts"
🗓️21-28Jul 🕗 8h-20h
📍ICBAS-UP, foyer Salão Nobre
🎟️free entrance

The exhibit "From Artifacts to Facts" is a tribute to Prof Teixeira da Silva (1932-2012), legendary #UPorto academic and researcher at the inception of IBMC, one of #i3S founding institutes.
#SciArt #outreach

A well deserved tribute to a great man and an outstanding scientist.

ySPI logo

We are proud to present ySPI, the newly established youth initiative of the Portuguese Society for Immunology (SPI), approved in April 2025.
The ySPI has been created by and for young scientists.
Our mission is to connect, support students and young researchers who are passionate about immunology.

Metabolic imprinting drives epithelial memory during mucosal fungal infection Epithelial cells at barrier sites are emerging as active participants in innate immune memory, yet the underlying metabolic and epigenetic mechanisms remain unclear. Here, we uncover a previously unre...

Check out our new preprint Metabolic imprinting drives epithelial memory during mucosal #fungal infection. Thanks to all collaborators www.biorxiv.org/content/10.1...

Imidazole propionate is a driver and therapeutic target in atherosclerosis - Nature Imidazole propionate produced by gut microbiota is associated with atherosclerosis in mouse models and in humans, and causes the development of atherosclerosis through activation of the imidazoline-1 ...

💥 A gut microbe metabolite that drives #atherosclerosis?
Yes—Imidazole propionate (ImP) triggers vascular inflammation without changing cholesterol.
🧪 We show the pathway—and how to block it.
nature.com/articles/s41... #OpenAccess at
@Nature
@CNIC_CARDIO
#CVD #immunosky #cardiosky #microbiomesky

Epigenetic silencing of interleukin-10 by host-derived oxidized phospholipids supports a lethal inflammatory response to infections Upon pathogen detection, phagocytes trigger immunity. This process induces tissue stress and the formation of host-derived molecules that further tune immune responses. We show that host-derived oxidi...

#EpigeneticPower! 💥 #NewPaperAlert! We show @cp-immunity.bsky.social that endogenous oxidized lipids decide whether host survives or dies during #sepsis, #ARDS, or Staph infection! Ox lipids bind & inhibit #AKT, boosting inhibitory H3K27 methylation via EZH2 & blocking #IL10!

Congrats, Norman!

Fungal infections are getting harder to treat The fungus Aspergillus fumigatus tops the World Health Organization's list of worrying fungal diseases. It's growing increasingly resistant to the first-line drug used to treat it.

Fungal infections are getting harder to treat. The fungus Aspergillus fumigatus tops the World Health Organization's list of worrying fungal diseases. It's growing increasingly resistant to the first-line drug used to treat it.
www.nbcnews.com/health/healt...

Fungal infections are getting harder to treat The fungus Aspergillus fumigatus tops the World Health Organization's list of worrying fungal diseases. It's growing increasingly resistant to the first-line drug used to treat it.

Quoted here about the increasing problem of drug resistance in Aspergillus isolates.
www.nbcnews.com/health/healt...

🎓 ICVS secures over €2.27M from FCT for 11 research projects in neuroscience, regenerative medicine, infectious diseases & more. A major boost for scientific excellence!
🔗 Learn more: icvs.uminho.pt/icvs-secures...

📣 Next #Communicable drops Mon 14 July!
@angelahuttner.bsky.social & @josh-nosanchuk.bsky.social invite Arturo Casadevall @acasadevall1.bsky.social (Johns Hopkins) to discuss the spread of #fungi due to climate change, and what that means for fungal pathogenesis & infection
#IDSky #clinmicro #MedSky

Interested in working on Mucorales adaptation? Thanks to new funding from @wellcometrust.bsky.social, we will have two postdoc and a technician positions advertised very soon! if interested, please get in touch for more information.

🔥🗞️Olorofim for the treatment of invasive fungal diseases in patients with few or no therapeutic options: a single-arm, open-label, phase 2b study.

Groundbreaking work on a very promising new antifungal. Free access here:

authors.elsevier.com/c/1lHca5E-Uo...

A Functional Polymorphism in IL-36ß Modulates Macrophage Antifungal Effector Functions and Increases Susceptibility to Invasive Pulmonary Aspergillosis Genetic predisposition plays a major role in the development of invasive pulmonary aspergillosis (IPA). The risk and course of IPA vary significantly among patients, yet continuously new genetic mechanisms that influence individual antifungal immune responses are being discovered

A Functional Polymorphism in IL-36ß Modulates Macrophage Antifungal Effector Functions and Increases Susceptibility to Invasive Pulmonary Aspergillosis

✅ Just Accepted
#IDSky

🚨Our latest review in Thorax about the impact of climate change focusing on fungal pathogens in Europe 🌍

A truly enjoyable collaboration with Sarah Sedik @germhuntermd.bsky.social @martinhoenigl.bsky.social and @mbottery.bsky.social

thorax.bmj.com/content/earl...

Health risks with environmental changes and mould exposure. Key impacts of flooding include increased precipitation, rising sea levels and land use changes, leading to indoor mould growth and health risks such as respiratory issues, asthma exacerbation and mould infections. Case studies highlight varying health outcomes from Hurricane Katrina and Rita (2005), Colorado Flood (2013) and Hurricane Harvey (2017).

Drivers of emerging fungal pathogens in a changing world. Climate change factors, such as rising temperatures and increasing resistance to fungicides, enhance fungal thermotolerance and drive the emergence of pathogens. Social determinants, including urbanisation, global travel and limited healthcare access, heighten human vulnerability to fungal infections. Other contributing factors, like environmental niches and unconfirmed environmental sources, further support the spread and persistence of fungal pathogens. These drivers contribute to the emergence of pathogens like Candida auris, Candida orthopsilosis and Cryptococcus deuterogatii.

Climate change and antifungal resistance: key mechanisms and pathogen examples. Climate change drives the development of antifungal resistance through mechanisms such as environmental pollution with fungicides, prolonged heat stress and increased mutation rates in fungi. These conditions promote genetic mutations, increased resistance to antifungal drugs and more challenging infections in humans and plants

Climate change: shifting boundaries of fungal disease in Europe and beyond

New review in Thorax

by @mbottery.bsky.social Sarah Sedik @germhuntermd.bsky.social @martinhoenigl.bsky.social @normanvanrhijn.bsky.social

thorax.bmj.com/content/thor... #MedSky #IDSky #PulmSky #ClimateSky #MedMycoSky

a soccer player wearing a red jersey with the number 7 ALT: a soccer player wearing a red jersey with the number 7

Portugal won the UEFA Nations League!!! 🇵🇹🇵🇹🇵🇹😁💪🏻🎉🍾🥂