We are incredibly excited by TSL spinout @ResurrectBio's successful initial closing of its Series A funding round at ⭐️ $8.1M ⭐️
Resurrect Bio is revolutionizing agriculture by equipping crops with genetic defenses against disease 🌱🛡️
www.tsl.ac.uk/news/tsl-spi...
It’s that time of year! #SchoBozKa in Downing College, Cambridge 🇬🇧
Running strong since 2017–Annual lab meeting of the teams of Sebastian Schornack, Lida Derevnina, Phil Carella, Jiorgos Kourelis and Sophien Kamoun.
This year’s guest is Steven Spoel, University of Edinburgh
Join us on March 10, 2026 at Kyoto University 🇯🇵 for a day celebrating my long-time friend and collaborator Prof. Ryohei Terauchi.
"Kyoto Mini-Symposium on Plant–Microbe Interactions"
We’re hiring!
Postdoctoral Researcher / Research Assistant @KamounLab
“Biology and Applications of Plant Immune Receptors” www.tsl.ac.uk/working-at-t...
Thrilled to join the @kamounlab.bsky.social! Looking forward to contributing and collaborating on exciting projects ahead. Thanks for the warm welcome Sophien!
Congrats 🎉
CC-NLRs exhibit diverse conformations in the resting state. Figure depicts different NLR resting and activated states. While ZAR1 exists as a monomer bound to its guardees in its resting state, several forms have been observed for the NRC2 helper, including dimers, tetramers, and filaments. While filament-like structures were observed via confocal microscopy for NRC2 upon overexpression in planta, these structures were not detected for its paralog NRC4, suggesting a potentially different resting state configuration for NRC4. Our work suggests that the Pik CC-NLR pair forms a hetero-complex bound to the plasma membrane in its resting state. How effector binding to the integrated domain (ID) of the Pik-1 sensor leads to the activation of the complex remains to be determined.
Excited to share our latest work on plant immune receptor biochemistry! @kamounlab.bsky.social @hsuanpai.bsky.social @mpcontreras.bsky.social Jose Salguero Linares @danielluedke.bsky.social @adnroide.bsky.social @jiorgoskourelis.bsky.social
www.biorxiv.org/content/10.6...
Now published in @newphyt.bsky.social , congrats @matteogravino.bsky.social @saskiahogenhout.bsky.social et al @johninnescentre.bsky.social nph.onlinelibrary.wiley.com/doi/10.1111/...
8/
🌟Congrats to the amazing team:
@matteogravino.bsky.social
@samtmugford.bsky.social
Daniela Pontiggia
Joshua Joyce
Claire Drurey
David Prince
Felice Cervone
Giulia De Lorenzo
@saskiahogenhout.bsky.social
🙏Thanks to editor Carlos Ballaré & referees for their valuable feedback!
7/
🧬Our model also includes recent findings:
· Mp10’s immune suppression involves interaction with AMSH deubiquitinases
👉 Matteo Gravino and @samtmugford.bsky.social work: bsky.app/profile/samt...
· Other aphid effectors actively target EDS1
👉 @qunliu07.bsky.social's work: bsky.app/profile/qunl...
Model: Activation and suppression of defences in plant–aphid interactions. Upper left panel: aphid stylet penetration of the cell wall releases oligogalacturonides (OGs), which induce PAMP/DAMP-triggered immunity (PTI/DTI) in a process dependent on BRASSINOSTEROID INSENSITIVE 1-ASSOCIATED RECEPTOR KINASE 1 (BAK1), ENHANCED DISEASE SUSCEPTIBILITY 1 (EDS1), and CPK5/6/11 (data herein). The stabilisation of pattern recognition receptors (PRRs) and coreceptors at the plasma membrane may rely on the deubiquitination (DUB) activity of ASSOCIATED MOLECULE WITH THE SH3 DOMAIN OF STAM (AMSHs; Gravino et al., 2024). Upper right panel: the Mp10 effector, introduced by aphids into the cell cytoplasm (Mugford et al., 2016), suppresses OG-induced reactive oxygen species (ROS) (data herein) and flg22-induced PTI (Bos et al., 2010). Mp10 targeting of plant AMSHs is implicated in these processes (Gravino et al., 2024). EDS1 is essential for Mp10-mediated ROS suppression and PRR destabilisation (data herein), acting through an unidentified mechanism (denoted by the double-sided arrow with an asterisk). Lower left panel: effector-triggered immunity (ETI) is activated through EDS1, either directly or indirectly, upon recognition of Mp10 and/or its activities by a TNL (Gravino et al., 2024; Rao et al., 2024). Salicylic acid glucosyltransferase 1 (SGT1) is also required for TNL/ETI activation (Bos et al., 2010). Lower right panel: aphids secrete additional effectors, such as cathepsin B proteins (e.g. CathB6), which target EDS1 to suppress ETI (Liu et al., 2025). Solid arrows, increased activation; solid blunt-ended arrows, increased suppression; Dashed arrows, reduced activation; Dashed -blunt-ended arrows, reduced suppression.
6/
🔑 Conclusion: EDS1 mediates Mp10's dual function—suppressing DTI/PTI and triggering ETI.
🧩 Mp10 operates at the crossroads of PTI/DTI and ETI, manipulating plant immunity to the aphid’s advantage.
5/
We found Mp10's effect is EDS1-dependent.
Without EDS1:
· No ETI
· PRRs stabilize
· DTI/PTI aren't suppressed
⏩ Aphids colonise more easily
4/
However, Mp10 also triggers ETI-like responses, including chlorosis—ultimately reducing aphid success. Why?
3/
But aphids fight back. How?
🛡️ They suppress OG production upon wounding
🧬 And deploy Mp10, an aphid-secreted saliva effector protein that:
· Reduces OG/flg22 sensitivity
· Destabilises pattern recognition receptors (PRRs)
2/
💥 DTI—triggered by the plant cell-wall-derived fragments oligogalacturonides (OGs)—strongly limits aphid colonisation. This defence requires:
· BAK1/BKK1
· CPK5/6/11
· GRP3
· EDS1
Peach–potato aphid (Myzus persicae)
🧵1/
We explored how the polyphagous peach–potato aphid (Myzus persicae) colonises Arabidopsis thaliana, and uncovered a key role for DAMP-triggered immunity (DTI).
Model: Activation and suppression of defences in plant–aphid interactions. Upper left panel: aphid stylet penetration of the cell wall releases oligogalacturonides (OGs), which induce PAMP/DAMP-triggered immunity (PTI/DTI) in a process dependent on BRASSINOSTEROID INSENSITIVE 1-ASSOCIATED RECEPTOR KINASE 1 (BAK1), ENHANCED DISEASE SUSCEPTIBILITY 1 (EDS1), and CPK5/6/11 (data herein). The stabilisation of pattern recognition receptors (PRRs) and coreceptors at the plasma membrane may rely on the deubiquitination (DUB) activity of ASSOCIATED MOLECULE WITH THE SH3 DOMAIN OF STAM (AMSHs; Gravino et al., 2024). Upper right panel: the Mp10 effector, introduced by aphids into the cell cytoplasm (Mugford et al., 2016), suppresses OG-induced reactive oxygen species (ROS) (data herein) and flg22-induced PTI (Bos et al., 2010). Mp10 targeting of plant AMSHs is implicated in these processes (Gravino et al., 2024). EDS1 is essential for Mp10-mediated ROS suppression and PRR destabilisation (data herein), acting through an unidentified mechanism (denoted by the double-sided arrow with an asterisk). Lower left panel: effector-triggered immunity (ETI) is activated through EDS1, either directly or indirectly, upon recognition of Mp10 and/or its activities by a TNL (Gravino et al., 2024; Rao et al., 2024). Salicylic acid glucosyltransferase 1 (SGT1) is also required for TNL/ETI activation (Bos et al., 2010). Lower right panel: aphids secrete additional effectors, such as cathepsin B proteins (e.g. CathB6), which target EDS1 to suppress ETI (Liu et al., 2025). Solid arrows, increased activation; solid blunt-ended arrows, increased suppression; Dashed arrows, reduced activation; Dashed -blunt-ended arrows, reduced suppression.
🎉Thrilled to share our latest work, now published in @newphyt.bsky.social!
🧑🔬 @matteogravino.bsky.social, @samtmugford.bsky.social, @saskiahogenhout.bsky.social et al., @johninnescentre.bsky.social
#️⃣ #PlantScience #PlantImmunity
📄 Read the full paper👇
nph.onlinelibrary.wiley.com/share/8QSRJ9...
Aphid Saliva fans, happy news, this amazing story is now out in Science Advances www.science.org/doi/10.1126/... congrats @qunliu07.bsky.social @saskiahogenhout.bsky.social et al @johninnescentre.bsky.social 24h after a triumphant presentation at #ismpmi2025
🔗 Preprint alert: www.biorxiv.org/content/10.1...
🧵 New insights into plant immunity: using ferns to understand evolution! 🌱✨🌿
Excited to share my first (but not last) published research at @lrsv-toulouse.bsky.social. A THREAD … [1/9]
📜 Aphid effector Mp10 balances immune suppression and defence activation through EDS1-dependent modulation of plant DAMP responses
🧑🔬 @matteogravino.bsky.social, @saskiahogenhout.bsky.social, et al.
📔 @biorxiv-plants.bsky.social
🔗 www.biorxiv.org/content/10.1...
#️⃣ #PlantScience #PlantImmunity
We are excited to share our latest preprint from the Hogenhout lab (@matteogravino.bsky.social @saskiahogenhout.bsky.social
, @johninnescentre.bsky.social
) on plant-aphid interactions, showing that the aphid effector Mp10 balances suppression of DAMP responses and activation of ETI via EDS1.
We’re delighted to share our latest preprint from the Hogenhout lab (@saskiahogenhout.bsky.social) on the molecular mechanisms on plant-aphid interactions. Here we show how the aphid Mp10 effector protein acts as a local anaesthetic to suppress the plant perception of aphid attack
