Neurology Mainz

Kicking off this year‘s annual DGN Congress in Berlin with an opening symposium focused on resilience, which included an engaging panel discussion. Looking forward to more interesting presentations over the next few days! #dgnkongress2025.

Bruton’s tyrosine kinase inhibitors rescue neuronal impairment caused by B cell–mediated lymphotoxin-α release Lymphotoxin-α release from B cells impairs neuronal activity in coculture models, which is reversible upon BTK inhibitor treatment.

In our latest study, out now in Sci Transl Med, we show that B cell-released lymphotoxin-α impairs human neuronal activity, which is reversible upon BTK inhibitor treatment. Thank you to everyone involved in this exciting work! @science.org

Johannes and Natascha were happy for the opportunity to present their work at ISNI.

Lots of great talks so far at ISNI 2025!

In Monday’s Poster Session you can find Johannes Wittig and on Tuesday Natascha Becht and Stefan Bittner will also have posters.

Frauke Zipp giving the Keynote Lecture at the International Society for #Neuroimmunology in Chiba, Japan. We’re excited for several of our group members to be in Japan for this great meeting!

Amazing location (Maritime Museum of Barcelona), wonderful atmosphere, great people! Our group enjoyed getting to relax and interact with others from the #MultipleSclerosis research community at the #ECTRIMS2025 Party. 🥳

Highlights from day 2 at #ECTRIMS2025 📸

Muriel, Maria and @katrinpape.bsky.social enjoying the chance to present their work. #iWiMS

Thank you #ECTRIMS for giving clinician scientists like Muriel Schraad the opportunity to present their work to such a diverse and impactful community.

Poster Session 2
👉P655 @katrinpape.bsky.social: Ageing-related immune signatures in multiple sclerosis
👉P743 Maria Protopapa: GFAP as promising biomarker for fatigue severity in multiple sclerosis

We're looking forward to sharing our work with the ECTRIMS community!

We're excited for another great day at #ECTRIMS2025!

In the Free Communications 6 session (11:15-12:30 Lecture Hall 117), Muriel Schraad will present her talk entitled "Choroid plexus enlargement associates with serum neurofilament and predicts relapse-free progression in #MultipleSclerosis. More👇

After a full busy day at #ECTRIMS, can’t beat having this view directly next to the Congress center! 🌅

A few snapshots from Day 1 of #ECTRIMS2025!

Check out our e-Posters:
👉Yvonne Gärtner (P1340) AMPA receptor Blockade in neuroinflammation
👉Felix Luessi (P1539) CSF proteins and neuroaxonal damage
👉Josef Shin (P1977 Late Breaking) BTKi rescues neuronal impairment

Today Sept 24
👉Stefan Bittner will be speaking about the clinical implementation of fluid biomarkers as part of Educational Session 6 (8:30-9:30, Lecture Hall 12)

Poster Session 1
👉Falk Steffen (P252) - neurofilament as biomarker for relapse
👉Tobias Brummer (P309) - treatment of pwMS & psoriasis

We‘re looking forward to lots of interesting presentations and opportunities to (re)connect with others working in the #MS field at #ECTRIMS2025! Come find us at our posters or talks outlined below! 👇

Role of CD5 signalling for pro-inflammatory Th17 response in multiple sclerosis Pape et al. link the CD5-CK2-STAT3 signalling pathway to both inflammation and effector function in multiple sclerosis, using a multi-modal approach that c

Excited to see our paper on the CD5 signalling pathway in Th17 cells and its role in #MultipleSclerosis out in @brain1878.bsky.social today. Thanks to everyone involved in this great team work! @neurologymainz.bsky.social @toszkabohn.bsky.social #ImmunoSky
academic.oup.com/brain/advanc...

AMPAR inhibition lowers S1P in human blood and improves murine autoimmune neuroinflammation by blocking T cell egress from lymph nodes A clinically available AMPAR antagonist inhibits T cell egress from lymph nodes and shows therapeutic effects in mouse models of multiple sclerosis.

Out now in #SciTranslMed! We show non-canonical activity of AMPA receptor signaling in T cells. Oral selective noncompetitive AMPA receptor blockade ameliorates neuroinflammation by preventing T cell egress from lymph nodes and therefore may be repurposed to treat inflammatory conditions such as MS.

Thank you to everyone who helped make the first European meeting of our Neuroimmune GRC a success! It was an amazing week of interesting science, lively discussions, and lovely evenings enjoying the Italian atmosphere. We look forward to our next meeting in 2027!

Frontiers | Biomarker combinations from different modalities predict early disability accumulation in multiple sclerosis

In our new paper, we show that multimodal biomarkers, i.e. different major surrogates for pathology derived from MRI, OCT and blood, inform about different parts of MS disease pathology leading to clinical progression.

Congrats! 👏

Happy to join the Bluesky Community!