www.biorxiv.org/content/10.6...
05.03.2026 09:06
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www.biorxiv.org/content/10.6...
First preprint from the lab! Using intracellular recordings & analysis of 2-photon imaging data, we show that spiking & neuromodulatory input during experience drive a reorganization of visuomotor inputs in V1 layer 2/3 neurons, consistent with enhanced visuomotor cancellation - bioRxiv link below.
Peer review would be easier if we stopped treating it like combat with the authors. Results want to be free, and perfect is the enemy of good. Do the data support the conclusions? If so, that’s enough. A paper isn’t a blank slate for projecting your own ideas.
Orbitofrontal cortex drives predictive filtering of sensory responses
www.nature.com/articles/s41...
#neuroskyence
Our work with @georgkeller.bsky.social on testing predictive processing (PP) models in cortex is out on biorvix now! www.biorxiv.org/content/10.6... A short thread on our findings and thoughts on where we should move on from PP below.
Please share: Postdoc position available in a new collaborative SNSF project with @georgkeller.bsky.social at @fmiscience.bsky.social using a cross-species approach in humans and mice to investigate the cortical circuit mechanisms underlying schizophrenia. Apply at karriere.upk.ch/Postdoctoral...
Congrats!!
A new preprint from our lab with @zelechowski.bsky.social & @georgkeller.bsky.social !
Using wireless EEG + VR, we recorded visuomotor mismatch responses in freely moving humans.
Huge thanks to all participants, Keller Lab members and FMI facilities!
Read more: www.biorxiv.org/content/10.1...
Thrilled to share our new Adesnik lab paper!!
Using holography in excitatory & inhibitory neurons, we reveal how a single cortical circuit can both complete and cancel predictable sensory activity, sharpening representations
📄https://www.biorxiv.org/content/10.1101/2025.08.02.668307v1
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Ditching months-long delays for fast, constructive feedback.
This interview with @solygamagda.bsky.social dives into the experience of publishing with eLife and what it could mean for a more open and efficient future in science.
Defending science in public we often talk about 'peer reviewed science'. But could this framing contribute to undermining trust in science and holding us back from improving the scientific process? Instead, let's talk about the work that has received the most thorough and transparent scrutiny? 🧪
Quality of scientific papers questioned as academics ‘overwhelmed’ by the millions published
Widespread mockery of AI-generated rat with giant penis in one paper brings problem to public attention
@iansample.bsky.social writes @theguardian.com
www.theguardian.com/science/2025...
The construction of the interpretation, however, appears to be built on the assumption that if something is predictable in principle it will be predicted by the brain. I would look to behavioral relevance to make guesses about what the brain predicts.
New
@plosbiology.org
paper:
doi.org/10.1371/jour...
We found neurons in rat auditory cortex that signal narrow predictions for specific tones.
Using omissions as a probe, we show that some neurons show frequency-specific expectations despite responding broadly to actual sounds. 🧵
A statistical error known as pseudoreplication appears in more than half of recent mouse studies on neurological disorders, according to a new study. Peter Kind and Constantino Elfetheriou tell Lauren Schenkman why researchers should pay attention.
www.thetransmitter.org/pseudoreplic...
Mice harboring mutations in Fmr1, Cntnap2 or Shank3B show a blunted update of priors during decision-making, suggesting that distinct genetic instantiations of ASD may yield common neurophysiological and behavioral phenotypes
www.nature.com/articles/s41...
New preprint, w/ @predictivebrain.bsky.social !
we've found that visual cortex, even when just viewing natural scenes, predicts *higher-level* visual features
The aligns with developments in ML, but challenges some assumptions about early sensory cortex
www.biorxiv.org/content/10.1...
📣 Save the date for the 11th PCI webinar on June 18, 2025, at 4 PM CET!! Brandon Stell (CNRS, Paris) will present "Elevating Scientific Standards: Community-Driven Assessment on PubPeer ". For more details and registration, visit: buff.ly/XuownT0
In the battle against brain disease, researchers can now rely on a new arsenal of genetic tools – The Armamentarium.
Together with scientists from across the NIH BRAIN Initiative, we’ve created and published over 1000 new enhancer AAV vectors.
🧠📈
So the tired "preprints shouldn't be cited because they're not peer reviewed" meme is back. Reminder these frequently cited items aren't peer reviewed either:
Editorials
Books
Reviews [some not all]
News reports
Data
Code
Websites
Social media posts
Citations are just links...intent varies 1/2
And that’s a wrap! What an amazing #neuroday2025 we’ve had. Thank you to all participants inc speakers, posters & exhibitors for showcasing the fantastically broad range of research taking place across our vast @edinunineuro.bsky.social community. 🧠🧠🧠
Jeremiah Cohen standing in front of a giant green neuron.
THIS IS ONE NEURON! Jaw dropping.
It distributes a particular neurotransmitter (norepinephrine) across the mouse brain; it’s a locus coeruleus neuron.
@jeremiahycohen.bsky.social and colleagues at the @alleninstitute.bsky.social are using new biotech to see things never seen before.
1. Project on Computational Neuroscience / NeuroAI PhD, supervised jointly with Caswell Barry @caswell.bsky.social
Here we want to build NeuroAI models that transform visual information to spatial navigation information.
www.findaphd.com/phds/project...
Top-down prediction signals from the medial prefrontal cortex govern auditory cortex prediction errors
doi.org/10.1016/j.ce...
#neuroscience
This week's sensorimotor superlab reading list is out @andpru.bsky.social @diedrichsenjorn.bsky.social @paulgribble.bsky.social #neuroskyence #psychscisky #Sensorimotor https://superlab.ca/posts/2025-04-04-list289.html
Just in case you - as we did - were wondering whether humans would have any of these pesky visuomotor mismatch responses certain people have seen in mice...
If only we had a system like @elife.bsky.social where peer review was public and accountable, we wouldn’t have to “rely” on peer review to “validate” papers!
Elife has a new editor-in-chief. An opportunity to remember that Elife proposes a modern peer review system fostering transparency, fairness, and immediacy. Elife has contributed to move the entire system in these important directions, and hopefully will continue doing so.
Join us at the BNA Festival of Neuroscience! Researchers Rebecca Jordan, Danai Katsanevaki, Matt Jones & Oliver Hardt will share their latest work, with a focus on how genetic changes in neurodevelopmental conditions affect brain function, behaviour & cognition.
@beckyjordan.bsky.social
More holiday gifts from the lab. Out in Cell Reports, beautiful work by Dr. Karolina Socha reveals how nasal, back-to-front visual motion can trigger arousal-related behavioral state changes that modulate responsiveness and stimulus selectivity in the mouse visual thalamus.
doi.org/10.1016/j.ce...
