So I pleased to announce the conceptual spawn of FigTree: PearTree (acronym still to be finalised). If you want to dive right in it is hosted as a web app here: artic-network.github.io/peartree (click the “Example...” button for immediate candy and then click every button you can find).
Interesting and good work on arbovirus coinfection. However, if cell entry is a low barrier (as some have shown), Don’t we need to redefine active (co)infection as being different from just (co)occurrence of pathogens? Replication counts.
🦠 Mpox: a better understanding of tecovirimat resistance
🔬 Scientists at the Institut Pasteur have uncovered how a viral enzyme interacts with tecovirimat. This breakthrough paves the way for new antiviral therapies.
📄 Study published in @naturemicrobiol.bsky.social #Mpox #tecovirimat
www.ecdc.europa.eu/sites/defaul...
Fabulous work with colleagues in Burundi, who took up Mpox sequencing to understand the situation AND are willing to share pre-publication, shows the expanding tree, and evidence for several introductions not taking off. In progress virological.org/t/preliminar...
@flodebarre.bsky.social had already pointed it out but I suspect you guys are taking the joke too seriously. It’s neither about the content of the paper nor whether it is accessible at this time or not. It’s simply about the irony of discussing accessibility in an inaccessible article
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Hot off the press: "Fecal microbial load is a major determinant of gut microbiome variation and a confounder for disease associations" www.sciencedirect.com/science/arti...
See below for @suguru-nishijima.bsky.social 's thread on the preprint!
#microsky #microbiome
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Great job on this. What’s an example of a prototype pathogen-vector pair …
🦇🦠If you ever wondered about the zoonotic risk bat-associated parasites might pose and their potential role in pathogen spillover look into our new paper in @TrendsParasitol
www.cell.com/trends/paras...
🕷️📷: @NikolaRahme
🦇🪰📷: @tszentivanyi
"Compressing long-term gene evolution to laboratory time spans at scale ... would enable the systematic detection of additional structural and functional demands governing biology...& principles by which gene diversity was generated in the first place."
www.science.org/doi/10.1126/...
A metagenomic catalogue of the ruminant gut archaeome www.nature.com/articles/s41... #jcampubs
After editing, this very short letter to New Scientist is even shorter now. But I think it gets the point across! @faecalmatters.bsky.social
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The perfect conclusion to a criticism doesn’t exi…
Dear fellow microbiologists, have you ever successfully pooled 16S and ITS amplicons in the same library to be sequenced together? Any tips to share? Thanks! 🧪🦠🧬
And this isn’t just theory. We’ve already use R10 for #H5N1 cases in #Cambodia to detect a new reassortant, and nail down that transmission was bird-to-human, not human-to-human. That’s a BIG deal for outbreak response—speed and confidence when it counts.
More here: www.medrxiv.org/content/10.1...
SEM of a lichen crossection
Here is something to distract you from the gloom: What can metagenomics tell us about the taxonomic composition of lichen symbioses? A peer-reviewed version of our analysis of >400 lichen metagenomes from around the world is now out in @PLOSBiology 1/12 doi.org/10.1371/jour...
🧬 🖥️ 🧪 🦠 🧫 #SymbioSky
EVEscape - predicting emergence of new viral escape lineages: www.nature.com/articles/s41... #VGEB24
Post peer review: Work we did in Yunnan Province China during the SARS-CoV2 pandemic. Myotis laniger is a potential host for SARSr-CoVs
www.sciencedirect.com/science/arti...
Please add me.
Yes! Contaminating genes in metagenomics may independently correlate with your target pathogen load. Food for thought
Intragenomic conflicts with plasmids and chromosomal mobile genetic elements drive the evolution of natural transformation within species (PLOS Biology)
from @epcrocha.bsky.social and colleagues
journals.plos.org/plosbiology/...
Great paper looking at phyologenetics+genetics of transformation
“…that if he had a gallon of urine and put a shot glass of wine into it, he still had a gallon of urine. On the other hand, if he had a gallon of wine and put a shot glass of urine into that, he now had a second gallon of urine”
This should be a guiding tenet for all journals if you ask me.
Complete genomes of Asgard archaea reveal diverse integrated and mobile genetic elements - out today in Genome Research
from @luisvalentin.bsky.social @archaeal.bsky.social @valdeanda.bsky.social
A look at (a) MGEs, (b) methylation, (c) defense systems in Asgards
genome.cshlp.org/content/earl...
Sharing code publicly is a double edged sword in that way: making the work reproducible, but also making it more easily disprovable. I still choose transparency
