@martaolivasantiago
MSCA RepliFate PhD Fellow at UCPH @ucph.bsky.social | Pharmacist | Exploring DNA Replication & Repair in ๐ธ | Part of ASAP-BioCrowd @asapbio.bsky.social & EDRA webinars @edra-webinars.bsky.social
We go live!!!
Join us Munich July5-7th to hear exciting research on #Replication by leaders in the field
AND !! registration is FREE ๐ฅณ (but mandatory) - we hope to see many in Munich ๐บ @helmholtzmunich.bsky.social
@replifate.bsky.social @epicrossborders.bsky.social
replifate.eu/event/meetin...
'Just bypass it: mechanisms of DNA damage tolerance' takes a fresh look at how cells replicate damaged DNA. The review, by RepliFate-affiliated @duxinlab.bsky.social (@bric-ucph.bsky.social, @ucph.bsky.social), revisits lesion bypass in light of recent advances
DOI: 10.1016/j.tibs.2025.07.004
Congrats, and welcome to the academic club, Amรฉlie! ๐๐๐ฉโ๐ฌ
Such a learning experience supervising you.
This Tuesday, RepliFate Fellows traded pipettes for pitch decks in a full-day #entrepreneurship workshop hosted by Lead Discovery Center GmbH.
๐กA great opportunity for our fellows to think differently about impact, #innovation, and #business development.
The last EDRA webinar of the year is today at 4 pm with Julian Stingele presenting the role of RNA damage in chemotherapy, followed by Andre Bortolini Silveira on BER and MMR converge, and Nicola Pietro Montaldo on Mitochondrial DNA Repair and Parkinson's Disease
@edra-webinars.bsky.social
BRIC Day with the theme collide across each other โ all about sparking new intra-institute collaborations.
Kickoff with a keynote from Rasmus Rabรธl (Klifo) and a buzzing poster session full of science-in-the-making!
@bric-ucph.bsky.social
Today we swapped pipettes for putters.
Day 2 retreat highlight: realizing that hitting the fairway is way harder than hitting a replication fork ๐
Off to Nord Sjรฆlland with the Miller lab @tcr-miller.bsky.social for our joint retreat! Exciting brainstorming, bonding, and a little hygge ahead.
First challenge: design your next @natureportfolio.nature.com article ๐
What makes #cshldnarep special isnโt just the cutting-edge, top-notch science; itโs the chance to meet the authors of the papers we build on every day, exchange ideas, and feel part of this community.
Heading home exhausted, grateful, full of ideas and renewed motivation to push my project forward!
Such a great experience presenting my poster at #CSHL!
Thanks to everyone who stopped by for the chats, feedback, and energy. Iโm bringing back lots of ideas!
This week weโre atย CSHL #cshldnarep where the DNA replication & genome maintenance community has gathered for a week of science, discussions, and late-night brainstorming.
Next webinar: Jessica Downs will discuss on how the SWI/SNF complex maintain genome integrity at G-quadruplexes. Yasmina Djeghmoum will talk on how transcription impacts on D-loops and on HR. Sree Rama Chaitanya will discuss on how BRCA2 variants shape chromatin & transcription ๐ lnkd.in/e9gbJkAf
Sometimes DNA replication hits a ๐ roadblock.
Cells donโt stop; they take clever detours (DNA damage tolerance) ๐๐จ to keep genomes intact.
Thatโs the focus of our new review in @cp-trendsbiochem.bsky.social:
โJust bypass it: mechanisms of DNA damage toleranceโ
๐ doi.org/10.1016/j.ti...
It is not always safe to repair DNA Damage. Sometimes, cells "just bypass it".
During DNA replication, repair of lesions on DNA can be dangerous. Cells instead "tolerate" DNA damage and focus on finishing replication.
Read our review and find out why and how: doi.org/10.1016/j.ti...
Just published!
Lecona (@emlecona.bsky.social ) & Mรฉndez #RepliFate labs show that VCP/p97 removes Pol ฮฑ/primase from chromatin to avoid excess ATR activation during normal #DNAreplication
VCP/p97 = checkpoint gatekeeper!
Read the full study: doi.org/10.1038/s414...
Weโre excited to welcome artist Helen Pynor to @cbm-csic-uam.bsky.social as part of the #RepliFate artist-in-residence program! ๐จ๐งฌ
From June 24โJuly 5, sheโll explore how #DNAreplication shapes cell fate & cancer, bridging science & art with our researchers.
#SciArt #ArtInScience
Frogs in the lab? Yep! ๐ธ
This week, RepliFate PhD students are diving into the Xenopus egg extract system at the @duxinlab.bsky.social (@bric-ucph.bsky.social, @ucph.bsky.social) -where test tubes meet frog magic to unravel the mysteries of DNA replication and genome integrity.
Our labโs a little more crowded (and a lot more curious) this week! ๐ง ๐ธ
Weโre thrilled to welcome @RepliFate students for a hands-on course in Xenopus egg extracts.
They're diving into the Xenopus world and learning how this powerful system helps us explore DNA replication and genome stability.
#CBC
Chromosome Biology Club is back today!
Join us for two exciting talks:
๐งฌ Christian Nielsen (CCS/ICMM) on the distinct roles of condensins I & II in mitotic chromosome mechanics
๐งฌ Judit Pilmark (BRIC) on mutational signatures linked to NER deficiency
Starting at 4.45 pm
Followed by pizzas and beer
๐ #ClimateActionDay is here!
For the first time, the University of Copenhagen @ucph.bsky.social is joining forces to take real steps toward a greener future
At BRIC @bric-ucph.bsky.social, weโre putting words into action!
Small changes can make a big impact ๐ฑ
#GreenLabs #SustainableScience
#WomenInScience
KU @ucph.bsky.social is marking 150 years since women were first allowed to study at the university!
Nielsine Nielsen was Denmarkโs first female doctor, marking a major milestone in the path toward gender equality.
The full program of events and celebrations here: kvinder150.ku.dk
Itโs time for new duo: Julius Thomas & his PI Lorenza Penengo from the University of Zurich.
They study the ISG15 system in DNA replicationโbut thereโs more! One could be found scaling alpine peaks, while the other might just trade the lab for the thrill of mushroom hunting. Curious to know more? ๐
๐จ#CBC is happening today!
Donโt forgetโour next Chromosome Biology Club is today at 16:45 at the Biocenter! Three great speakers and exciting science await, followed by beer and pizza. See you there!
This is happening today!
Find the Zoom link here: dnarep.sciencesconf.org
Happy to share our latest pre-print!
We solved the cryoEM structures of human DNA repair factor MRN bound to DNA and to TRF2. Main work of Yilan, Filiz @filizkuybu.bsky.social and Hengjun. Great collab within the @sfb1361.bsky.social and @genecenter-lmu.bsky.social ๐งฌ๐จ
www.biorxiv.org/content/10.1...
Thrilled to share our lab's first preprint, led by an exceptional PhD student Gita Chhetri and with the support of wonderful collaborators, we find that replisome function is rate-limited by strand-specific PCNA dynamics. Hope you will enjoy reading.
www.biorxiv.org/content/10.1...
Brief teaser:
๐
Our next Chromosome Biology Club is next week!
Join us on March 25th at the Biocenter for exciting talks from:
โ Johanna Kliche (Nilsson group, @nilssonlab.bsky.social)
โ Oline Pade Jensen (Lisby group)
โ Luke Greenhough (Steve West group, @xrnchew.bsky.social)
Mark your calendars! #CBC
๐งช Researchers at IRB Barcelona develop the first single-cell map of transcriptomes in yeast.ย
โ๏ธ Mariona Nadal-Ribelles, @laia-de-nadal.bsky.social, Francesc Posas et al.
๐ฐ @naturecomms.bsky.socialย
โก๏ธ https://shorturl.at/R8i9e
๐DOI: 10.1038/s41467-025-57600-4
#IRBScience
๐ขย Reminder! Just a few days to go!
๐ฌ Thisย Tuesday, March 25th, weโll be exploringย Nanofluidic tools for studying DNA repairย withย Fredrik Westerlund, as well asย R-loops & genome instabilityย withย Sidrit Uruci & Agnese Cristini.
๐๏ธย Save the date & join us!
#DNARepair
Weโre kicking off our RepliFate introductions with @Phuc and her PI, @sylvie-noordermeer.bsky.social ! As part of the RepliFate network, they are contributing to exciting research in double-strand break (DSB) repair. Wanna know more about their work, hobbies, and fun facts? Check out their profiles!